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Eosinophils are considered essential in the pathogenesis of allergy. Reduced eosinophil apoptosis is considered to be a key element in the formation of eosinophilia in allergic conditions. Antihistamines are widely used in the treatment of allergic disorders, but their effects on eosinophil apoptosis are poorly understood. The histamine HI-receptor antagonist, ketotifen, is available orally and as
Swedish guidelines for thrombosis risk estimation and thrombosis prophylaxis in relation to pregnancy are based on risk factors with a 5-fold increased risk of thrombosis or some multiple thereof. The risk factors are added together forming a risk score, where by risk score 1 is associated with a 5-fold increased risk, risk score 2 with a 25-fold increased risk, etc. The absolute risk of thrombosi
The structures of 2(diphenylphosphino)acetophenone and bis(2(diphenyl phosphino)acetophenone)palladium(II)bistriflate have been determined by X-ray crystallography. The ligand is of interest because its P,O donor set combines the hard and soft properties. In the Pd-complex, which was prepared by treating tetrakisacetonitrile-palladium-bistriflate with 2-(diphenylphosphino)acetophenone in dichlorom
A numerical model is presented that simulates sediment transport and profile response produced by overwash of dunes by wave runup. Transport formulas are derived for the different regions of the subaerial portion of the beach covering the swash zone, beach and dune crest, and region landward of the crest. After calculating the distribution of the cross-shore sediment transport rate, profile respon
The effect of the extent of electron conjugation on the primary photophysics in semiconducting polymers is reported. A rapid depolarization of photoluminescence and transient absorption, which indicates a reorientation of the transition dipole moment by ~30° on a sub-100 fs time scale, is observed in the fully conjugated polymer poly[2-(2'-ethylhexyloxy)-5-methoxy-1,4-phenylenevinylene] (MEH-PPV).
This study investigated whether the relation between implicit and explicit homonegativity measures is affected by self-presentation concerns, since previous research in this area has been inconclusive. In Experiment 1, 70 high-school students made evaluative ratings of pictures of homosexual and heterosexual couples. Self-presentation was manipulated by either instructing participants that the stu
The brain lesions in spontaneously hypertensive stroke-prone rats (SHRSP) are characterised by multifocal microvascular damage, breakdown of the blood-brain barrier, massive extravasation of plasma constituents and severe brain oedema, with consequent spongy and cystic tissue destruction in the cerebral cortex and basal ganglia as well as loosening of the white matter. In this paper we analyse in
Several microbial pathogens have been reported to interact with glycosaminoglycans (GAGs) on cell surfaces and in the extracellular matrix. Here we demonstrate that M protein, a major surface-expressed virulence factor of the human bacterial pathogen, Streptococcus pyogenes, mediates binding to various forms of GAGs. Hence, S. pyogenes strains expressing a large number of different types of M prot
Background: Optimal therapeutic management of intravascular lymphoma (IVL) lacks precise guidelines. Patients and methods: The clinico-pathological features of 38 HIV-negative patients with IVL were reviewed to define efficacy of chemotherapy in these malignancies. Clinical characteristics of 22 patients treated with chemotherapy and of 16 untreated patients were compared in order to understand be
This paper takes the treatment of antonymy in Collins COBUILD Advanced Learner's English Dictionary (2003) as the point of departure for a discussion about the principles of antonym inclusion in dictionaries and corpus methodologies in lexicology. CCALED includes canonical antonyms such as good/ bad and dead/alive, as well as more contextually restricted pairings such as hot/ mild and flat/fizzy.
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The complexes formed by the reaction of [Ti(OiPr)(4)] and bicyclo-octanediols (BODOLs) 1 and 2 (1:1) are useful as chiral catalysts in asymmetric reductions and were investigated by H-1 NMR spectroscopy and computational methods. A consistent picture emerged of head-to-tail dimers being kept together via a Ti-O-Ti-O mu-oxo bridge similar to the Ti-tartrates but different from the corresponding Ti-
Long-term treatment with the dopamine precursor levodopa (L-DOPA) induces dyskinesia in Parkinson's disease (PD) patients. We divided hemiparkinsonian rats treated chronically with L-DOPA into two groups: one showed motor improvement without dyskinesia, and the other developed debilitating dyskinesias in response to the treatment. We then compared the plasticity of corticostriatal synapses between
Three approaches for modelling evacuation in the event of fire were studied based on existing computer programs. The programs included in the study were ERM, EVACNET4, STEPS, buildingEXODUS and SIMULEX. However, only some aspects of buildingEXODUS were examined. The three approaches, called network models (ERM and EVACNET4), gridmodels (STEPS and buildingEXOUDUS) and particle models (SIMULEX) diff
We investigate the two-particle spin entanglement in magnetic nanoclusters described by the periodic Anderson model. An entanglement phase diagram is obtained, providing an important perspective on a central property of magnetic nanoclusters, namely, the temperature-dependent competition between local Kondo screening and nonlocal Ruderman-Kittel-Kasuya-Yoshida spin ordering. We find that multipart
A measurement of inclusive jet cross-sections in deep-inelastic ep scattering at HERA is presented based on data with an integrated luminosity of 21.1 pb(-1). The measurement is performed for photon virtualities Q(2) between 5 and 100 GeV2, differentially in Q(2), in the jet transverse energy E-T, in E-T(2)/Q(2) and in the pseudorapidity eta(lab). With the renormalization scale mu(R) = E-T, pertur
An exhaustive and simple method for dispersion flattening in double-clad single-mode fibers is presented. The idea is to generate all such fibers with a certain cutoff wavelength and then find, by one-dimensional minimization and direct inspection, fibers yielding minimum dispersion. As examples, the root mean square chromatic dispersion over the wavelength range (1.25, 1.60 mum) is minimized for
