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utomotive systems offer a rich opportunity for hybrid models, controls, and tools. Beyond the traditional use of hybrid models for representing the behavior of the composition of discrete controller and continuous plants, automotive mechanical systems exhibit hybrid behavior as demonstrated in this chapter. In addition, hybrid systems can be used to capture system specifications at the highest lev
Formulaic language is a crucial component of language overall, and therefore merits the development of tests capable of yielding valid and reliable scores. However, the diverse nature of formulaic language poses challenges for test design. This chapter will critique existing tests of formulaic language and discuss principles for the development of future tests. Key issues include construct definit
Coronary artery disease (CAD) is a major cause of death and disability. Several diagnostic tests, such as myocardial perfusion scintigraphy (MPS), are accurate for the detection of CAD, as well as having prognostic value for the prediction of cardiovascular events. Nevertheless, the diagnostic and prognostic value of these tests should be cost-effective and should lead to improved clinical outcome
Vid kronisk myeloisk leukemi har målstyrd, kontinuerlig behandling med tyrosinkinashämmare lett till dramatiskt förbättrad överlevnad. Efter ett flertal år uppnås djupt molekylärt svar hos ca 50 procent av patienterna; ca 50 procent av dem kan då avbryta behandlingen utan tecken på återfall. Kontinuerlig behandling med tyrosinkinashämmare kan ge långsiktiga biverkningar. Efter patentutgång för imaChronic myeloid leukemia - a model disease for targeted therapy Chronic myeloid leukemia (CML) pioneered as the first human malignancy linked to a specific cytogenetic aberration (the Philadelphia chromosome), which led the way to specific targeted therapies with imatinib (Glivec) and later tyrosine kinase inhibitors (TKI). Continuous TKI administration, blocking the oncogenic fusion protein Bcr-A
Despite the fact that the origin of human immunodeficiency virus (HIV) being a contamination and a mutation originating from primates is well-documented alternative narratives are often being heard ofespecially in sub-Saharan Africa. One such narrative is about HIV being man-made in a military laboratory in the United States. In this article, it is shown how this narrative was fabricated by the in
Introduction: COPD has complex etiologies involving both genetic and environmental determinants. Among genetic determinants, the most recognized is a severe PiZZ (Glu342Lys) inherited alpha1-antitrypsin deficiency (AATD). Nonetheless, AATD patients present a heterogeneous clinical evolution, which has not been completely explained by sociodemographic or clinical factors. Here we performed the gene
Purpose: Transcriptional pathway activity and the molecular subtypes of breast cancer metastases have been shown to significantly influence patient postrelapse survival. Here, we further determine the relevance of clinically employed gene signatures in the advanced breast cancer (ABC) setting. Experimental Design: Sufficient RNA for expression profiling was obtained from distant metastatic or inop
Background: Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availability of dosimetry-based MRT in clinical practice and research studies. The aim of this study was to assess the current practice of MRT and dosimetry across European countries. Metho
Background - Previous reports have implicated multiple genetic loci associated with AF, but the contributions of genome-wide variation to AF susceptibility have not been quantified. Methods and Results - We assessed the contribution of genome-wide single-nucleotide polymorphism variation to AF risk (single-nucleotide polymorphism heritability, h2 g) using data from 120 286 unrelated individuals of
Purpose: In 90Y microsphere radioembolization (RE), accurate post-therapy imaging-based dosimetry is important for establishing absorbed dose versus outcome relationships for developing future treatment planning strategies. Additionally, accurately assessing microsphere distributions is important because of concerns for unexpected activity deposition outside the liver. Quantitative 90Y imaging by
För ett stort antal elever i ungdoms- och vuxenutbildning gäller det attta sig an den komplexa uppgiften att både utveckla kunskaper i olikaämnen och att erövra ett helt nytt språk: svenska. Språktillägnandetbehöver understödjas på allra bästa sätt för att nå en nivå som kan mötade höga språkliga krav som ställs inom utbildning, yrkesliv och samhälle.Detta ställer i sin tur stora krav på andrasprå
Boken presenterar på ett populärt sätt forskningsresultat från arkeologi, geologi och historieforskning. Det geografiska perspektivet omfattar Skåne under förhistorisk tid men därefter Kävlinge socken. Uppgiften om ett slag på Kävlingebro omkring 1020 föranledde en arkeologisk undersökning vilket presenteras. Lantbrukets utveckling utgör en viktig tråd i boken. Rikt illustrerad.
BACKGROUND: Malignant mesothelioma (MM) is an aggressive, fatal tumor. Current therapeutic options only marginally improve survival. Programmed cell death ligand 1 (PD-L1) is a dominant mediator of immunosuppression, binding to programmed cell death 1 (PD-1). PD-L1 is up-regulated in cancer cells, and the PD-1/PD-L1 pathway plays a critical role in tumor immune evasion, thus providing a target for
En källa från Ryds klosters årsbok skriver om slaget på Kävlingebro cirka 1020. Invid broläget påträffades en cirkulär anläggning som efter arkeo-/ geologiska undersökningar visade sig vara en kreatursfålla. Artikeln söker anledningen til det eventuella slaget och fållans funktion i närområdet. Ulf jarls härkomst till norra Skåne prövas.
Objective: Idiopathic pulmonary fibrosis (IPF) is a devastating disease with no cure and is characterized by deranged epithelial repair, myofibroblast activation, and excess deposition of extracellular matrix. Yes associated protein (YAP) and transcriptional co-regulator with PDZ-binding domain(TAZ), co-transcriptional activators of the Hippo pathway and proto-oncogenes, were recently found to be
Trabecular bone is viscoelastic under dynamic loading. However, it is unclear how tissue viscoelasticity controls viscoelasticity at the apparent-level. In this study, viscoelasticity of cylindrical human trabecular bone samples (n = 11, male, age 18–78 years) from 11 proximal femurs were characterized using dynamic and stress-relaxation testing at the apparent-level and with creep nanoindentation
