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Striatal Glutamate Release in L-DOPA-Induced Dyskinetic Animals

L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-L-alanine (L-DOPA) in Parkinson's disease. The biological mechanisms behind this side effect are not fully comprehended although involvement of dopaminergic, serotonergic, and glutamatergic systems has been suggested. The present study utilizes in vivo amperometry to investigate the impact

Necrotizing myositis and septic shock caused by Haemophilus influenzae type f in a previously healthy man diagnosed with an IgG3 and a mannose-binding lectin deficiency

An increased incidence of infections by Haemophilus influenzae type f (Hif) has recently been suggested, but such infections have mainly been regarded as opportunistic. We present here a dramatic case of Hif necrotizing myositis and septic shock. A subsequently diagnosed IgG3 and mannose-binding lectin deficiency possibly contributed to the severe outcome.

U-Pb (zircon) age constraints on the timing and duration of Wen lock (Silurian) paleocommunity collapse and recovery during the "Big Crisis"

High-precision isotope-dilution U-Pb (zircon) dating was conducted on three volcanic ash fall (bentonite) samples from the Swedish island of Gotland, and on a fourth bentonite from the West Midlands, England. Zircons from the Ireviken, Grotlingbo, Djupvik (Gotland), and Wren's Nest Hill-15 (West Midlands) bentonites yielded weighted mean Pb-206/U-238 ages of 431.83 +/- 0.23/0.67 Ma, 428.45 +/- 035

The Tumbleweed: towards a synthetic protein motor

Biomolecular motors have inspired the design and construction of artificial nanoscale motors and machines based on nucleic acids, small molecules, and inorganic nanostructures. However, the high degree of sophistication and efficiency of biomolecular motors, as well as their specific biological function, derives from the complexity afforded by protein building blocks. Here, we discuss a novel bott

Does Economics Have a Gender?

We are pleased that our paper on gender balance in the economics profession incited a number of commentaries on "Why few women in economics?" ( all in May 2008 Econ Journal Watch). The commentators include one sociologist, one psychologist, and three non-traditional economists-making for great breadth. Here we address the issues that seem most important to us. Our paper provided original documenta

An international round robin test on isothermal (conduction) calorimetry for measurement of three-day heat of hydration of cement

The results of a round robin test on isothermal (heat conduction) calorimetry are presented. A total of 18 participants using three types of instruments conducted 3-day measurements of the hydration of one rapidly hardening Portland cement and one slag-containing cement. The results confirm that isothermal calorimetry is a suitable method for the determination of heat of hydration. As a part of th

Numerical simulation of a gas-liquid Rushton stirred reactor - LES and LPT

Abstract in UndeterminedSimulations of aerated stirred reactor is performed using a combination of large eddy simulation (LES) and Lagrangian particle tracking (LPT). A single impeller Rushton turbine is positioned at the center of the reactor and air is introduced at the bottom through a circular sparger. Effects of the gas volume flow, stirrer speed and sparger dimension are investigated. The re

Designing High-Quality Embedded Control Systems with Guaranteed Stability

Many embedded systems comprise several controllers sharing available resources. It is well known that such resource sharing leads to complex timing behavior that degrades the quality of control, and more importantly, can jeopardize stability in the worst-case, if not properly taken into account during design. Although stability of the control applications is absolutely essential, a design flow dri

Wigner-localized states in spin-orbit-coupled bosonic ultracold atoms with dipolar interaction

We investigate the occurence of Wigner-localization phenomena in bosonic dipolar ultracold few-body systems with Rashba-like spin-orbit coupling. We show that the latter strongly enhances the effects of the dipole-dipole interactions, allowing to reach the Wigner-localized regime for strengths of the dipole moment much smaller than those necessary in the spin-orbit-free case.

Structure of the Mature Streptococcal Cysteine Protease Exotoxin mSpeB in Its Active Dimeric Form

Invasive infections of Streptococcus pyogenes are dependent on the cysteine protease streptococcal pyrogenic exotoxin B. Previous structures of the enzyme have not disclosed the proper active-site configuration. Here, the crystal structure of the mature enzyme is presented to 1.55 angstrom, disclosing a homodimer. A serine from one subunit inserts into the active site of the other to donate to the

Direct observation of double-k lattice modulation in double-k magnetic structures. The case of CeAl2

Symmetry analysis is combined with x-ray scattering experiments to investigate the lattice modulation associated with the incommensurate magnetic structure in the case of a double-k structure. The expansion of the free energy shows that the components of the magnetic structure with propagation vectors k(1) and k(2) can couple via components of lattice modulations. It is shown that the classical di