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Photoinduced interfacial electron injection in RuN3-TiO2 thin films: Resolving picosecond timescale injection from the triplet state of the protonated and deprotonated dyes

Using femtosecond transient absorption spectroscopy we have studied light-induced electron injection from the sensitizer RuN3 and its partly deprotonated tetrabutylamonium salt to nano-structured TiO2 film. Previous studies have suggested significant differences in electron injection dynamics for these dyes and some results have indicated that aggregation of the sensitizer may lead to slow injecti

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.

Whereas maintenance of hematopoietic stem cells (HSCs) is a requisite for life, uncontrolled expansion of HSCs might enhance the propensity for leukemic transformation. Accordingly, HSC numbers are tightly regulated. The identification of physical cellular HSC niches has underscored the importance of extrinsic regulators of HSC homeostasis. However, whereas extrinsic positive regulators of HSCs ha

Versican V2 Assembles the Extracellular Matrix Surrounding the Nodes of Ranvier in the CNS

The CNS-restricted versican splice-variant V2 is a large chondroitin sulfate proteoglycan incorporated in the extracellular matrix surrounding myelinated fibers and particularly accumulating at nodes of Ranvier. In vitro, it is a potent inhibitor of axonal growth and therefore considered to participate in the reduction of structural plasticity connected to myelination. To study the role of versica

Pt-Rh/MgAl(O) Catalyst for the Upgrading of Biomass-Generated Synthesis Gases

The impact of the main contaminants usually present in the gas generated during gasification of biomass was studied on a Pt-Rh/MgAl(O) reforming catalyst, which was exposed to solutions of K2SO4, KCl, and ZnCl2 and also to a leached solution of biomass fly ash by aerosol technology on a laboratory scale. The catalyst was exposed to a product gas of a bench-scale downdraft gasifier as well. Untreat

A research agenda for improving national Ecological Footprint accounts

Nation-level Ecological Footprint accounts are currently produced for more than 150 nations, with multiple calculations available for some nations. The data sets that result from these national assessments typically serve as the basis for Footprint calculations at smaller scales, including those for regions, cities, businesses, and individuals. Global Footprint Network's National Footprint Account

Chemical ecology and insect conservation: optimising pheromone-based monitoring of the threatened saproxylic click beetle Elater ferrugineus

Elater ferrugineus is a saproxylic click beetle inhabiting old deciduous trees in Europe. It is threatened throughout its area of distribution due to habitat loss. No efficient monitoring method has been available for this species, but observed attraction of females to (R)-(+)-γ-decalactone, which is a male-produced sex pheromone of its prey, the scarab beetle Osmoderma eremita, has led to the dev

Serviceability floor loads

Serviceability of structures has to be verified for a lower load level than the design load used for safety considerations. Representative values of actions used in serviceability load combinations are often defined in a way that the fraction of time spent above a given load level should be limited to a certain value. To determine these load levels more information on the stochastic nature of the

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 x 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 x 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 x 10(-9)) and 22q13.1 (rs877

Maintenance of Basal Levels of Autophagy in Huntington's Disease Mouse Models Displaying Metabolic Dysfunction.

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded polyglutamine repeat in the huntingtin protein. Neuropathology in the basal ganglia and in the cerebral cortex has been linked to the motor and cognitive symptoms whereas recent work has suggested that the hypothalamus might be involved in the metabolic dysfunction. Several mouse models of HD that display metabol

On the Ability of PAMAM Dendrimers and Dendrimer/DNA Aggregates To Penetrate POPC Model Biomembranes.

Poly(amido amine) (PAMAM) dendrimers have previously been shown, as cationic condensing agents of DNA, to have high potential for nonviral gene delivery. This study addresses two key issues for gene delivery: the interaction of the biomembrane with (i) the condensing agent (the cationic PAMAM dendrimer) and (ii) the corresponding dendrimer/DNA aggregate. Using in situ null ellipsometry and neutron

CHAOS AND STRUCTURE OF LEVEL DENSITIES

Two coexisting facets of warm nuclei, quantum chaos and structure of the level density, are considered. A newly developed combinatorial level-density model is presented, and the role of collective enhancements discussed. An example of extreme parity enhancement is shown.

Immunization with cationized BSA inhibits progression of disease in ApoBec-1/LDL receptor deficient mice with manifest atherosclerosis.

Immune responses against modified self-antigens generated by hypercholesterolemia play an important role in atherosclerosis identifying the immune system as a possible novel target for prevention and treatment of cardiovascular disease. It has recently been shown that these immune responses can be modulated by subcutaneous injection of adjuvant. In the present study we immunized 25-week old ApoBec

Regulation of cellular growth and identification of stromal gene signatures in breast cancer

Popular Abstract in Swedish Cancer är ett samlingsnamn för flera hundra sjukdomar som har gemensamt att de har fått en okontrollerad celldelning till följd av genetiska förändringar. Celldelning sker ständigt i vår kropp när gamla celler måste bytas ut och nya kopior bildas. Vid dessa processer sker det ofta mutationer i vårt DNA så att informationen förändras, vilket resulterar i att skadan kopieNormal tissue is tightly controlled to keep a balance between reproduction and elimination of cells. In cancer, these regulated processes are disrupted, resulting in uncontrolled cell growth. Regulation of RNA stability and turnover is important to maintain cellular homeostasis and can be controlled by various mechanisms. During stress, the cell can form cytoplasmic complexes of proteins and RNAs,

Statistical iterative reconstruction algorithm for X-ray phase-contrast CT.

Grating-based phase-contrast computed tomography (PCCT) is a promising imaging tool on the horizon for pre-clinical and clinical applications. Until now PCCT has been plagued by strong artifacts when dense materials like bones are present. In this paper, we present a new statistical iterative reconstruction algorithm which overcomes this limitation. It makes use of the fact that an X-ray interfero

Mallomonas pseudocoronata Prescott (Synurophyceae), a recent arrival in Scania, southern Sweden?

Since the early 1960s, water chemistry and phytoplankton have been monitored in several lakes in Sweden. However, as early as 1900-1901, the German algologist Lemmermann investigated phytoplankton from lakes in Scania, southern Sweden. Several phytoplankton samples from these investigations were preserved and saved, and are deposited at the Department of Ecology in the University of Lund. These ol