This chapter analyses volunteer work for identifying and reporting accessibility faults in urban settings. By looking closely at how people monitor adherence to the accessibility standards of laws and human rights, it is possible to recognise and understand their concrete fight against exclusion and discrimination. The author uses ethnographic data from go-alongs with two ‘accessibility detectives

Aggressive cancers are characterized by hypoxia, which is a key driver of tumor development and treatment resistance. Proteins specifically expressed in the hypoxic tumor microenvironment thus represent interesting candidates for targeted drug delivery strategies. Carbonic anhydrase (CAIX) has been identified as an attractive treatment target as it is highly hypoxia specific and expressed at the c

Blood parasites (Haemosporidia) are thought to impair the flight performance of infected animals, and therefore, infected birds are expected to differ from their non-infected counterparts in migratory capacity. Since haemosporidians invade host erythrocytes, it is commonly assumed that infected individuals will have compromised aerobic capacity, but this has not been examined in free-living birds.

Background: The timing of migration substantially influences individual fitness. To match peak requirements with peak resource availability, we hypothesized that individual migrants schedule spring migration in close relation to seasonal changes in environmental conditions along the route and particularly, at the breeding destination.To test this hypothesis, we investigated the timing of spring mi

This chapter presents an overview of thermistor-based calorimetric measurements. Bioanalytical applications are emphasized from both the chemical and biomedical points of view. The introductory section elucidates the principles involved in the thermometric measurements. The following section describes in detail the evolution of the various versions of enzyme-thermistor devices. Special emphasis is

Natural selection can play an important role in the origin of new species. When reproductive isolation evolves as a result of ecologically-based divergent natural selection, the process is referred to as ecological speciation. In most organisms, sufficient reproductive isolation is considered to be essential for the establishment of new species. However, reproductive isolation typically involves m

The present invention relates to a medical article for containing a pharmaceutical protein preparation comprising at least a first component and a second component, having at least one surface coated with a coating to reduce the friction between the two components and to reduce the protein adsorption to the coating. The coating is a hydrophilic coating whereby the hydrophilicity of the surface of

BACKGROUND AND AIMS: This study aimed to expand the European Prospective Investigation into Cancer and Nutrition (EPIC) nutrient database (ENDB) by adding amino acid (AA) values, using the U.S. nutrient database (USNDB). Additionally, we aimed to evaluate these new protein and AA intake estimates from the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR) using different matching p

När de kritiska mönsterdimensionerna för högteknologiska enheter fortsätter krympa och mönstertätheten fortsätter öka, behöver även litografin att gå i samma riktning. En lovande teknologi är sampolymerlitografi, som har en upplösning under 10 nm, en mönsterperiodicitet omkring 7-200 nm, och lätt kan skalas upp till större ytor till en låg kostnad. Användandet av sampolymerer där de ingående blockAs high technology device patterns are continuing to move towards decreasing critical dimensions and increasing pattern density, there is a need for lithography to move in the same direction. Block copolymer (BCP) lithography is a promising technique, which has single digit nanometer resolution, has a pattern periodicity of about 7-200 nm, and easily scales up to large area at a low cost. The use

A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. A recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 (signal 2), and 42 (signal 3) credible causal variants at these loci. We used publicly available in silico DNase I and ChIP-seq data with in vitro reporter gene and CRISPR assays to annotat

The recent randomized controlled phase III CLEAR trial results are the last to complement immune checkpoint inhibitor (ICI)-based doublet combination therapies for treatment-naïve metastatic clear-cell renal cell carcinoma. The CLEAR trial demonstrated an improved progression-free survival (PFS), overall survival (OS), and an objective response rate (ORR) benefit for the combination of lenvatinib

Currently, a great deal of biomedical research in fields such as epidemiology, clinical trials and genetics is reliant on vast amounts of biological and phenotypic information collected and assembled in biobanks. While many resources are being invested to ensure that comprehensive and well-organised biobanks are able to provide increased access to, and sharing of biomedical samples and information

A rationale for an individuals-oriented landscape approach to sustainable land-use planning based on an analysis of bio-geo-physical components as well as the human components of the landscape is presented. A toolbox for analysing individuals’ decision-making and valuations in the landscape is described. The toolbox can provide evidence on the drivers of individuals’ decision-making in the landsca

The advent and refinement of sequencing technologies has resulted in a decrease in both the cost and time needed to generate data on the entire sequence of the human genome. This has increased the accessibility of using whole-genome sequencing and whole-exome sequencing approaches for analysis in both the research and clinical contexts. The expectation is that more services based on these and othe

The increasing implementation of next-generation sequencing technologies in the clinical context and the expanding commercial offer of genetic tests directly-toconsumers has increased the availability of previously inaccessible genetic information. A particular concern in both situations is how the volume of novel information will affect the processing of genetic and genomic information from minor

Plastic extension of Breviario de espejismos by Elena Mendoza. Glued paper, two speakers, amplifier, video, tablet, LED light, photographic montage, four metal supports, fishing line, metal strings, two wooden boxes, two mixed metal-wooden supports.