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Vertebrate extinctions and reorganizations during the Late Silurian Lau Event

During the Silurian Period, as shown here by data from Gotland, Sweden, and other regions of the Baltoscandian paleocontinent, fish faunas were struck hard by extinctions caused by the late Ludlow Lau Event, also known for being associated with the largest positive stable carbon isotope excursion of the Phanerozoic. This event had a profound impact on the early evolutionary history of vertebrates,

Conceptualizing entrepreneurial capital in the context of institutional change

This paper explores the building of entrepreneurial capital from an entrepreneurship and contextual/institutional position. In taking this position, it is possible to understand "entrepreneurial capital" as the content of the process that unfolds when individuals are exposed to certain characteristics of the environment. Drawing on findings from an ethnographically inspired longitudinal case study

Mn-induced modifications of Ga 3d photoemission from (Ga, Mn)As: evidence for long range effects

Using synchrotron based photoemission, we have investigated the Mn-induced changes in Ga 3d core level spectra from as-grown Ga(1-x)Mn(x)As. Although Mn is located in Ga substitutional sites, and therefore does not have any Ga nearest neighbors, the impact of Mn on the Ga core level spectra is pronounced even at Mn concentrations in the region of 0.5%. The analysis shows that each Mn atom affects

Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium

Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, hormonal status, HER2 status, patient age, and family history to name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. We therefore set out to explore the impact of hypoxia on mammary epithelial differentiation and what conseque

Factor VIIa binding to endothelial cell protein C receptor: Differences between mouse and human systems

Recent in vitro studies have shown that the zymogen and activated form of factor (F)VII bind to endothelial cell protein C receptor (EPCR). At present, there is no evidence that FVIIa binds to EPCR on vascular endothelium in vivo in the presence of circulating protein C, a primary ligand for EPCR. The present study was carried out to investigate the interaction of murine and human ligands with mur

Bone turnover markers are correlated with quantitative ultrasound of the calcaneus: 5-year longitudinal data.

Associations between bone turnover markers and calcaneal ultrasound (quantitative ultrasound, QUS) were studied in a population-based sample of 810 elderly women. Baseline bone turnover markers correlated with baseline QUS as well as with 5-year prospective changes in QUS. INTRODUCTION: Bone turnover markers are associated with areal bone mineral density, but the knowledge on the association with

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Pachnobium dreuxi, n. g., n. sp. discovered as a fossil and still living in the Crozet Islands (Coleoptera: Curculionidae: Ectemnorrhininae). Pachnobium dreuxi, a new genus and species of Ectemnorrhininae weevil, was first discovered as a fossil in a Holocene sedimentary sequence at lie de la Possession (Crozet Islands, southern Indian Ocean). Two modern specimens were subsequently found in the co

Sir2-dependent asymmetric segregation of damaged proteins in ubp10 null mutants is independent of genomic silencing.

Carbonylation of proteins is an irreversible oxidative damage that increases during both chronological and replicative yeast aging. In the latter, a spatial protein quality control system that relies on Sir2 is responsible for the asymmetrical damage segregation in the mother cells. Proper localization of Sir2 on chromatin depends on the deubiquitinating enzyme Ubp10, whose loss of function deeply

Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium.

During the life cycle of the filamentous bacteria Streptomyces, morphological differentiation is closely integrated with fundamental growth and cell-cycle processes, as well as with truly complex multicellular behaviour that involves hormone-like extracellular signalling and coordination with an extraordinarily diverse secondary metabolism. Not only are the bacterial cytoskeleton and the machineri

Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening.

BACKGROUND: Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clinical trials. Because the vast majority of women with positive cytology are also HPV DNA positive, screening strategies that use HPV DNA testing as the primary screening test may be more effective. METHO

On Automation of the PID Tuning Procedure

Within process industry, and in many other areas, the PID controller is responsible for handling regulatory control. An educated guess is that the number of executing PID control loops lies in the billions (2011) and there are no signs indicating a decrease of this number. Properly tuning the PID controller, i.e., setting its parameter values based on characteristics of the process it controls t

Pitfalls in Interpreting Umbilical Cord Blood Gases and Lactate at Birth

Popular Abstract in Swedish Förlossnings- och barnläkare har i många år sökt efter ett instrument för utvärdering av det nyfödda barnets hälsotillstånd. Virginia Apgar introducerade 1953 ett poängsystem som bygger på en subjektiv bedömning av barnets hudfärg, hjärtfrekvens,reflexer/retbarhet, muskeltonus och andning. Koncentrationen i blodet av olika gaser, syror och baser speglar också det nyföddAcid-base status in umbilical cord blood is an objective measure of the fetus’ exposure to and ability to handle hypoxia. The objective of this thesis was to clarify some of the methodological pitfalls in interpreting umbilical cord blood gases and lactate values at birth. Study I pinpoints the methodological confounding in calculating base deficit (BD) with algorithms used in different brands of

Males with high genetic similarity to females sire more offspring in sperm competition in Peron’s tree frog, Litoria peronii

Recent work has confirmed that genetic compatibility among mates can be an important determinant of siring success in sperm competition experiments and in free-ranging populations. Most of this work points towards mate choice of less related mates. However, there may also be the potential for mate choice for intermediate or even genetically similar mates to prevent outbreeding depression or hybrid

Tank-connected food waste disposer systems - Current status and potential improvements.

An unconventional system for separate collection of food waste was investigated through evaluation of three full-scale systems in the city of Malmö, Sweden. Ground food waste is led to a separate settling tank where food waste sludge is collected regularly with a tank-vehicle. These tank-connected systems can be seen as a promising method for separate collection of food waste from both households

Wage penalty of abstinence and wage premium of drinking-A misclassification bias due to pooling of drinking groups?

Several studies have found protective effects of low/moderate (hereafter 'light') alcohol consumption compared with 'abstinence' on mortality, health and wage. Some of these studies have been criticised because former drinkers have been included among the abstainers, which may overstate the protective effect of light alcohol consumption. It has also been proposed, but not shown, that the commonly

Late Holocene and modern glacier changes in the marginal zone of Solheimajokull, South Iceland

The forefield of the Solheimajokull outlet glacier, South Iceland, has a variety of glacial landforms and sediments that are products of late Holocene and modern glacier oscillations. Several sets of moraine ridges reflect past ice front positions and river-cut sedimentary sections provide information about past environments. Here, we describe sediments and landforms deposited during the late Holo

Modelling the impact of climate change and atmospheric N deposition on French forests biodiversity.

A dynamic coupled biogeochemical-ecological model was used to simulate the effects of nitrogen deposition and climate change on plant communities at three forest sites in France. The three sites had different forest covers (sessile oak, Norway spruce and silver fir), three nitrogen loads ranging from relatively low to high, different climatic regions and different soil types. Both the availability