Small noncoding RNAs are key controllers of cellular function, and their deregulation can lead to cancer development and metastatic evolution. This review summarizes the most important examples of small RNAs involved in human cancer and discusses their clinical use as biomarkers and drug targets for diagnosis, prognosis, and treatment of cancer. We also describe the possible mechanisms underlying

OBJECTIVES: To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata). DESIGN: Data from two international, double blind, placebo controlled, randomised efficacy trials of quadrivalent HPV vaccine (protocol 013 (FUTURE I) and protocol 015 (F

The problem considered here is that of simultaneously reconstructing spatially dependent velocity and dissipation profiles for a one-dimensional medium using a finite time trace of normal incidence reflection data measured on one side of the medium. It is shown that if the sup norm of the reflection data is bounded in a particular way, then this inverse problem is guaranteed to have a solution. A

Echocardiography has a vital role for diagnosing and monitoring infectious endocarditis. The recently published Swedish guidelines for diagnosis and treatment of infectious endocarditis recommend overuse of transoesophageal echocardiography, which is not supported by the literature. The European Society of Cardiology presents a considerably more appropriate opinion.

A palynological study of Upper Cretaceous and Lower Paleocene sections from South Island, New Zealand, revealed the presence of two new species of Carpatella: Carpatella septata sp. nov. and Carpatella truncata sp. nov. Both species are stratigraphically important and the first occurrence of C. septata is a significant uppermost Maastrichtian event. Carpatella truncata is restricted to a narrow st

A new EU directive on used vehicles has recently been introduced. It demands that for every scrapped car, at least 85% by weight must be recycled by the year 2006 and 95% by 2015. Today this level is about 80%. The growing car disassembly industry was chosen as the study object of this thesis. Due to the increased demands on recycling, the disassembly industry is expected to undergo comprehensive

A brief critical discussion of the value of autobiographical accounts, as found in Chinese archives, to the historian of modern China, with an aside on the anthology NINE LIVES (ISBN 978-91-978017-4-4) as published by the author and his students in 2011.

I den här artikeln studeras incestdebatten i Sverige under perioden 1982–96. Med utgångspunkt i ett diskursteoretiskt perspektiv undersöks politiska processer, kunskapsproduktion och kamp om tolkningsföreträde i relation till hur incest definierades, debatterades och hanterades. Materialet är enskilda aktörers eller hela organisationers diskursiva praktiker, så som de kom till uttryck i publicerad

Epithelial ovarian cancer (EOC) is the most lethal of all gynaecological malignancies and there is an urgent need to develop new prognostic and treatment predictive biomarkers for a more efficient therapy. The discovery of the RNA-binding motif protein 3 (RBM3) as a putative cancer biomarker was based on its differential expression in various cancer forms in the Human Protein Atlas (HPA). Further

This thesis focuses on multivariate multilevel modeling of panel data originated from smallholder farm surveys in Sub-Saharan African (SSA) countries and Vietnam to investigate driving forces in maize and rice production in SSA and diversification of farms in the rice sector in Vietnam. We also present and evaluate different tests for endogeneity in explanatory binary variables in multivariate lin