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Sverige och den västeuropeiska arbetslösheten 1970-1990

This dissertation studies the labor market development of fourteen Western European countries during the years 1970-90, focusing on the relatively low Swedish unemployment. The variation in unemployment over time and between countries has proved difficult to explain with the most influential theoretical models, which are usually categorized as New-keynesian and Post-keynesian respectively. The dis

Vintergatan - i. The origins of chemically, kinematically, and structurally distinct discs in a simulated milky way-mass galaxy

Spectroscopic surveys of the Milky Way's stars have revealed spatial, chemical, and kinematical structures that encode its history. In this work, we study their origins using a cosmological zoom simulation, VINTERGATAN, of a MilkyWay-mass disc galaxy. We find that in connection to the last major merger at z ∼ 1.5, cosmological accretion leads to the rapid formation of an outer, metal-poor, low-[α/

4MOST : The 4-metre Multi-Object Spectroscopic Telescope project at preliminary design review

We present an overview of the 4MOST project at the Preliminary Design Review. 4MOST is a major new wide-field, high-multiplex spectroscopic survey facility under development for the VISTA telescope of ESO. 4MOST has a broad range of science goals ranging from Galactic Archaeology and stellar physics to the high-energy physics, galaxy evolution, and cosmology. Starting in 2021, 4MOST will deploy 24

Quest for the Sun's siblings based on elemental abundances

We present stellar parameters, stellar ages, and detailed elemental abundances for Na, Mg, Al, Si, Ca, Ti, Cr, Fe, and Ni for 32 solar sibling candidates. Technique of chemical tagging gives us a high probability that four stars might be from the same open cluster. Only one candidate HIP 40317 which has solar metallicity and age could be a solar sibling. We performed simulations of the Sun's birth

The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC

Protein HC, an extremely charge-heterogeneous lipocalin, carries a yellow-brown fluorescent chromophore of unknown structure covalently bound at an unidentified site of its polypeptide chain. Two chromophore-carrying peptides with 60% of the chromophore material (defined as material absorbing light at 330 nm) were isolated from pepsin-digested native human protein HC by reversed-phase high perform

Imiquimod shows anti-viral actions in human bronchial epithelium - implications for COVID-19 treatment

Combining anti-viral and anti-inflammatory effects in a single drug may be beneficial in treating COVID-19. We hypothesized that the TLR7 agonist imiquimod (imq) may exert these actions in human bronchial epithelial cells (HBECs), which are targets in SARS-CoV-2 mediated lung injury. Methods: Using primary HBECs from asthmatic donors (N=18), we explored actions of imq related to airway viral resis

Diagnostic value of analysis of cystatin C and protein HC in biological fluids

Cystatin C, a 13 kDa-protein, is produced by most nucleated cells and is catabolized by the renal tubular cells after passing the glomerular filter. It belongs to the family 2 of the cystatin superfamily of proteins. The function of cystatin C is to regulate the activity of cysteine proteinases and cystatin C seems to be the main cysteine proteinase inhibitor of most investigated human biological

Oral fluoroquinolone use and the risk of acute liver injury: a nationwide cohort study

Antibiotics are considered to be among the most frequent causes of drug-related acute liver injury (ALI). Although many ALIs have mild and reversible clinical outcomes, there is substantial risk of severe reactions leading to acute liver failure, need for liver transplant, and death. Recent studies have raised concerns of hepatotoxic potential related to the use of fluoroquinolones.MethodsThis stu

Human cystatin C, a cysteine proteinase inhibitor, inhibits bone resorption in vitro stimulated by parathyroid hormone and parathyroid hormone-related peptide of malignancy

The effect of human recombinant cystatin C, a cysteine proteinase inhibitor, on bone resorption in vitro was evaluated. Bone resorption was assessed by analyzing the release of 45Ca and 3H from mouse calvarial bones prelabeled in vivo by injections with 45Ca or [3H]proline, respectively. In 24 h cultures, cystatin C (50 micrograms/ml) significantly inhibited the release of 45Ca and 3H stimulated b

A Biosensing Strategy for Fast Profiling of Antibiotic Resistance

Antibiotic resistance threatens global public health. Clinical methods that simplify and accelerate resistance diagnosis are urgently needed. Here we describe a function-based antibiotic resistance detection and classification strategy to improve diagnosis. The method identifies resistance enzymes by directly measuring the thermal signal generated when an antibiotic i enzymatically degraded. A sub