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The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level of anti-tumor activity. In spite of this important progress, however, nearly all MM patients ultimately relapse, even those who experience a complete response to initial therapy. Management of rel

Cigarette smoke exposure is well known to cause cardiovascular and airway diseases, both of which are leading causes of death and disability in the world. However, the molecular mechanisms that link cigarette smoke to cardiovascular and airway diseases are not fully understood. Vascular and airway hyper-reactivity plays an important role in the pathogenesis of cardiovascular and airway diseases. R

In addition to classical neurological symptoms, Huntington's disease (HD) is complicated by peripheral pathology and both the mutant gene and the protein are found in cells and tissues throughout the body. Despite the adipose tissue gene expression alterations described in HD mouse models, adipose tissue and its gene expression signature have not been previously explored in human HD.

Abstract not available

Lökk J, Borg S, Svensson J, Persson U, Ljunggren G. Drug and treatment costs in Parkinson's disease patients in Sweden. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2011.01517.x. © 2011 John Wiley & Sons A/S. Background - Parkinson's disease (PD) is a chronic neurodegenerative disease expected to cause great costs. The aim of this study was to calculate drug and treatment costs in patients with

In this work, we model the basic mechanisms of the interaction between phase-transformations and plasticity within a one-dimensional constitutive framework. Efficient algorithms are presented, facilitating to solve the underlying evolution equations with high numerical stability at low numerical costs. Furthermore, a family of functions covering physically reasonable classes for the inheritance of

Fashion and retail ought to be a happy marriage. Yet several entrepreneurs in the field of fashion speak of a climate that is difficult to penetrate because of economic and cultural factors. For example, the chain store concept is an expression of the specific and current fashion situation in Sweden: democratic fashion that is cheap and accessible. At the same time, customers now demand personal,

Observations of harmonic generation from solid Al targets irradiated at intensities of 1017 W/cm2 using a tabletop Ti:sapphire terawatt laser system are reported. For irradiances with laser light at a wavelength of [lambda] = 794nm (the fundamental frequency), harmonics up to the 7th, while for irradiances with frequency doubled laser light ([lambda] = 397) nm harmonics up to the 4th of the respec

In this paper we present a new, heuristic method for computing logarithms over GF(2P). When 2P-1 is a Mersenne prime <231-1 it works in very short running times on a general purpose computer. It is based on the interdependent relations f,~(t) = t-2~f(t) 2" and log f~s(t) = - 2' + 2" log f(t), where f and frs are polynomials over GF(2). Its cryptographic significance is discussed and it can be cons

Abstract Background. The impact of cancer on spouses of cancer patients may be considerable in many aspects. Our objective was to evaluate sick leave in spouses of cancer patients before and after the diagnosis. Material and methods. Using Swedish population-based registries, we studied sick leave of spouses to patients with newly diagnosed colon, rectal, lung, prostate, or breast cancer. We ident

This overview aims to give an indication of the current status and trends in occupational health epidemiology in the Nordic countries. As indicated by recent biometric reviews, Nordic countries currently rank among the top five globally in terms of research output on the work environment. However, birth-cohort effects and rapid change in institutions and funding may seriously jeopardize this posit