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Transport of a hyaluronan-binding protein in brain tissue

Hyaluronan is an unsulfated linear glycosaminoglycan with the ability to nucleate extracellular matrices by the formation of aggregates with lecticans. These matrices are essential during development of the central nervous system. In the prospective white matter of the developing brain hyaluronan is organized into fiber-like structures according to confocal microscopy of fixed slices which may gui

Postgång på växlande villkor : det svenska postväsendets organisation under stormaktstiden

Popular Abstract in Swedish Det svenska postväsendet grundades 1636 genom en kunglig förordning om postbud. Under det följande århundradet byggdes postnätet ut över riket och alla större städer fick postkontor. Från början sköttes verksamheten av staten, men under stormaktstiden förändrades organisationen flera gånger och lades vid ett par tillfällen ut på entreprenad. I doktorsavhandlingen PostgåThis dissertation investigates the Swedish postal service, focusing on its organization from approximately 1600 to 1720. The purpose of the study is to explain why the Swedish state, at different points of time, chose one form of postal organization over another. The principle question of the dissertation has been: How was the Swedish postal service organized during the 1600s, what were the forms

Leading Logarithms in the Massive $O(N)$ Nonlinear Sigma Model

We review Buchler and Colangelo's result that leading divergences at any loop order can be calculated using only one-loop calculations and we provide an alternative proof. We then use this method to calculate the leading divergences of and thus the leading logarithmic corrections to the meson mass in the massive $O(N)$ nonlinear sigma model to five-loop order. We also calculate the all-loop result

High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.

Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid. Amyloid fibrils form through smaller cell toxic intermediates and deposited amyloid disrupts normal islet architecture. Even though IAPP and amyloid formation are mu

Measurement of higher cumulants of net-charge multiplicity distributions in Au plus Au collisions at root s(NN)=7.7-200 GeV

We report the measurement of cumulants (C-n,n = 1, ..., 4) of the net-charge distributions measured within pseudorapidity (vertical bar eta vertical bar < 0.35) in Au + Au collisions at root s(NN) = 7.7-200 GeV with the PHENIX experiment at the Relativistic Heavy Ion Collider. The ratios of cumulants (e.g., C-1/C-2, C-3/C-1) of the net-charge distributions, which can be related to volume independe

MÅL C 457/10 P, ASTRAZENECA

Den 6 december 2012 kom EU-domstolens dom i målet. Den omfattar 206 domsmotiv mot tribunalens 920 – således ett relativt sett lättillgängligt aktstycke, vilket också ligger i sakens natur med den begränsade talerätten vid överprövning. AZ yrkade att kommissionens beslut skulle ogiltigförklaras på grund av: (i) tribunalens felaktiga rättstillämpning vad gällde fastställandet av den relevanta markna

Energy Fluctuations Shape Free Energy of Nonspecific Biomolecular Interactions

Understanding design principles of biomolecular recognition is a key question of molecular biology. Yet the enormous complexity and diversity of biological molecules hamper the efforts to gain a predictive ability for the free energy of protein-protein, protein-DNA, and protein-RNA binding. Here, using a variant of the Derrida model, we predict that for a large class of biomolecular interactions,

Large eddy simulation of turbulent combustion in a spark-assisted homogenous charge compression ignition engine

A large eddy simuation (LES) model is presented for simulation of spark-assisted homogeneous charge compression ignition combustion. The model is based on tabulated chemical kinetic rate for ignition and flame surface density for flame propagation, taking into account interaction between flame propagation introduced by the spark and auto-ignition due to charge compression. The model is used to sim

Long-term safety and efficacy of drug-eluting and bare metal stents in saphenous vein grafts

Background Long-term safety and efficacy data of drug-eluting stents (DESs) in saphenous vein grafts (SVGs) are lacking. This study sought to compare the clinical outcomes of DES versus bare metal stents (BMS) in SVGs. Methods We studied all stent implantations in SVGs in Sweden during 74 months between 2005 and 2011 registered in the Swedish Coronary Angiography and Angioplasty Registry. We evalu

Comparison of different modeling approaches to better evaluate greenhouse gas emissions from whole wastewater treatment plants

New tools are being developed to estimate greenhouse gas (GHG) emissions from wastewater treatment plants (WWTPs). There is a trend to move from empirical factors to simple comprehensive and more complex process-based models. Thus, the main objective of this study is to demonstrate the importance of using process-based dynamic models to better evaluate GHG emissions. This is tackled by defining a

Individual whole-body concentration of (137)Cesium is associated with decreased blood counts in children in the Chernobyl-contaminated areas, Ukraine, 2008-2010.

The Narodichesky region, Zhitomir Oblast, Ukraine, is situated ∼80 km from the Chernobyl Nuclear Power Plant, which exploded in 1986 and polluted the environment. A previous study found that children living in villages with high activity of (137)Cesium (Cs) in the soil had decreased levels of hemoglobin, erythrocytes and thrombocytes. These findings motivated the present study that used a more com

Palaeoglaciation of Bayan Har Shan, northeastern Tibetan Plateau: glacial geology indicates maximum extents limited to ice cap and ice field scales

Key locations within an extensive area of the northeastern Tibetan Plateau, centred on Bayan Har Shan, have been mapped to distinguish glacial from non-glacial deposits. Prior work suggests palaeo-glaciers ranging from valley glaciers and local ice caps in the highest mountains to a regional or even plateau-scale ice sheet. New field data show that glacial deposits are abundant in high mountain ar

A study on particles and some microbial markers in waterpipe tobacco smoke.

Waterpipe smoking is becoming increasingly popular worldwide. Research has shown that cigarette smoke, in addition to hundreds of carcinogenic and otherwise toxic compounds, may also contain compounds of microbiological origin. In the present study we analyzed waterpipe smoke for some microbial compounds. Both of the two markers studied, viz 3-hydroxy fatty acids of bacterial lipopolysaccharide (L

A variational formulation for interpolation of seismic traces with derivative information

We construct a variational formulation for the problem of interpolating seismic data in the case of missing traces. We assume that we have derivative information available at the traces. The variational problem is essentially the minimization of the integral over the smallest eigenvalue of the structure tensor associated with the interpolated data. This has the physical meaning of penalizing the l

Change in spring arrival of migratory birds under an era of climate change, Swedish data from the last 140 years

Many migratory bird species have advanced their spring arrival during the latest decades, most probably due to climate change. However, studies on migratory phenology in the period before recent global warming are scarce. We have analyzed a historical dataset (1873-1917) of spring arrival to southern and central Sweden of 14 migratory bird species. In addition, we have used relative differences be

Public Awareness of Sepsis Is Low in Sweden.

Background. Sepsis is a serious and common condition with high mortality and morbidity. The public awareness, knowledge, and perception of sepsis in Sweden are unknown. Methods. A survey was performed using an online interview distributed to adults, aged 18-74, between March 6 and 9, 2015. Results. A total of 1001 people responded to the survey. Twenty-one percent of participants had heard of seps