For centuries, mushrooms have been used as food and medicine in different cultures. More recently, many bioactive compounds have been isolated from different types of mushrooms. Among these, immunomodulators have gained much interest based on the increasing growth of the immunotherapy sector. Mushroom immunomodulators are classified under four categories based on their chemical nature as: lectins,

Objective: To explore the role of MTNR1B rs10830963 and G6PC2 rs560887 variants in the pathogenesis of impaired fasting glucose (IFG) in obese adolescents. Methods: A total of 346 Caucasians, 218 African-Americans, and 217 Hispanics obese children and adolescents underwent an oral glucose tolerance test (OGTT) and 518 underwent the evaluation of insulin secretion by the oral minimal model (OMM). A

Diagnosis of acute arterial mesenteric ischemia in the early stages is now possible using modern computed tomography with intravenous contrast enhancement and imaging in the arterial and/or portal phase. Most patients have acute superior mesenteric artery (SMA) occlusion, and a large proportion of these patients will develop peritonitis prior to mesenteric revascularization, and explorative laparo

Interrogative Belief Revision Based on Epistemic Strategies

This paper describes a measurement of the W boson transverse momentum distribution using ATLAS pp collision data from the 2010 run of the LHC at root s = 7 TeV, corresponding to an integrated luminosity of about 31 pb(-1). Events form both W -> e nu and W -> mu nu are used, and the transverse momentum of the W candidates is measured through the energy deposition in the calorimeter from the recoil

Accurate characterization of the errors in the global astrometric solution for Gaia is essential for making optimal use of the catalogue data. We investigate the structure of the covariance between the estimated astrometric parameters by studying the properties of the astrometric least squares solution. We find that astrometric errors can be separated in a star and an attitude part, due to the est

Banks hold capital to guard against unexpected surges in losses and long freezes in financial markets. The minimum level of capital is set by banking regulators as a function of the banks’ own estimates of their risk exposures. As a result, a great challenge for both banks and regulators is to validate internal risk models. We show that a large fraction of US and international banks uses contamina

Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder, and one of the most frequently encountered, but one for which there is as yet no treatment. Laminin-111 protein therapy was recently shown to be a promising approach to prevent muscle disease in the mdx mouse model of DMD. The present study demonstrated that transgenic expression of laminin α1 chain in mdx animals, resulting in

During the past 40 years brain tissue grafting techniques have been used both to study fundamental neurobiological questions and to treat neurological diseases. Motor symptoms of Parkinson's disease are largely due to degeneration of midbrain dopamine neurones. Because the nigrostriatal pathology is relatively focused anatomically, Parkinson's disease is considered the ideal candidate for brain re

Posterior corrective surgery using "all pedicle screw construct" carries risk of neurovascular complications. The study aims were to assess the screw placement in patients with adolescent idiopathic scoliosis using CT with low-radiation dose, and to evaluate the clinical outcome in patients with misplaced pedicle screws. CTs of 49 consecutive patients (873 screws, 79% thoracic) were retrospectivel

We present new major and trace element data, as well as Sm–Nd isotope compositions for Archaean supracrustal rocks and a gabbro-anorthosite complex from the island of Storø in Godthåbsfjord, southern West Greenland. We also provide new U–Pb isotope data for zircon extracted from these rocks. The Storø rocks have experienced amphibolite facies metamorphism, and the entire sequence forms an east-dip

OBJECTIVE: To compare robot-assisted laparoscopy and laparotomy for radical hysterectomy and pelvic lymphadenectomy in terms of hospital costs. METHODS: Consecutive women undergoing radical hysterectomy and pelvic lymphadenectomy as a sole procedure between January 2001 and February 2012 were included. We compared OR times, hospital stay, procedure specific costs, blood transfusions and cost for r

The debate about post-2012 global climate governance has been framed largely by proponents and opponents of the policymaking process established by the United Nations Framework Convention on Climate Change (UNFCCC). In light of the proliferation of institutions governing some aspects of climate change, analysts have asked whether a centralized or a polycentric climate governance architecture will

The purpose of the study was to evaluate how breathing motion during tomotherapy (Accuray, CA, USA) treatment affects the absorbed dose distribution. The experiments were carried out using gel dosimetry and a motion device simulating respiratory-like motion (HexaMotion, ScandiDos, Uppsala, Sweden). Normoxic polyacrylamide gels (nPAG) were irradiated, both during respiratory-like motion and in a st

We investigate whether Swedish Environmental Protection Agency (EPA) administrator recommendations regarding improvements in environmental quality differ from citizen preferences. This is done by conducting identical choice experiments on both citizens and administrators at the EPA. The administrators were asked to choose the alternatives they would recommend as a policy, while the citizens were a

The Model of Emissions of Gases and Aerosols from Nature (MEGANv2.1) together with the Modern-Era Retrospective Analysis for Research and Applications (MERRA) meteorological fields were used to create a global emission data set of biogenic volatile organic compounds (BVOC) available on a monthly basis for the time period of 1980-2010. This data set, developed under the Monitoring Atmospheric Compo

Det övergripande syftet med artikeln är att med hjälp av en teoretisk utgångspunkt beskriva, analysera och försöka förstå varför biståndshandläggarna i sin dagliga yrkesutövning normaliserar en restriktiv hållning när äldre personer överväger en flytt till ett särskilt boende. Medan tidigare forskning i stor utsträckning har uppmärksammat på vilket sätt biståndshandläggarna tillämpar en restriktivBy applying a theoretical point of departure, the overarching aim of this article is to describe, analyze, and try to understand why care managers in their everyday occupational practice normalize the restrictive approach when older people consider relocation to a residential home. While earlier research to a large extent has drawn attention to how the care managers carry out the restrictive appro

The aim of the study was to investigate workplace incivility as a social process, examining its components and relationships to both instigated incivility and negative outcomes in the form of well-being, job satisfaction, turnover intentions, and sleeping problems. The different components of incivility that were examined were experienced and witnessed incivility from coworkers as well as supervis