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Wilms' tumor gene 1 (WT1) is a transcription factor involved in developmental processes. In adult hematopoiesis, only a small portion of early progenitor cells express WT1, whereas most leukemias show persistently high levels, suggesting an oncogenic role. We have previously characterized oncogenic BCR/ABL1 tyrosine kinase signaling pathways for increased WT1 expression. In this study, we show tha

Popular Abstract in Swedish Avhandlingen belyser läsning och läsarbanor i ett livsperspektiv där fyra lärarstudenters berättelser om läsning från barndom till mötet med lärarutbildningen analyseras ur ett sociokulturellt perspektiv. Ur berättelserna om läsning i olika kontexter såsom familj, skola och lärarutbildning framträder ett perspektiv på läsning som en relationell process. I en relationellThe aim of the thesis is to contribute to knowledge about experience and perceptions of reading that students at a school of education have, from early reading experiences in childhood, to the encounter with reading in context of their teacher training. The following overarching questions were asked: What aspects of narratives appear to be significant in the students’ reading trajectories? Which a

Lichen cover and diversity were analysed on the dwarf shrub Helianthemum oelandicum (L.) Dum.Cours. at one site in the calcareous grassland of the area known as the ‘Great Alvar’ on the Island of Öland, Sweden. The age of 22 phorophytes was determined by ring counting and varied from 8 to 41 years and was accurately predicted by the root diameter. A total of 18 lichen species was found, with a ran

B vitamins and polymorphisms in genes coding for enzymes involved in one-carbon metabolism may affect DNA synthesis and methylation and thereby be implicated in carcinogenesis. Previous data on vitamins B2 and B6 and genetic polymorphisms other than those involving MTHFR as risk factors for gastric cancer (GC) are sparse and inconsistent. In this case-control study nested within the European Prosp

Obesity is increasing rapidly in all parts of the world and is now considered to be a global epidemic. Obesity is a major risk factor for several health issues such as type 2 diabetes (T2D) and cardiovascular disease. The adipose tissue is central in the maintenance of a normal energy homeostasis in the body for instance via regulating lipid storage and release. Besides being an important energy r

We report on measurements of the light absorption efficiency of InSb nanowires. The absorbed 70 fs light pulse generates carriers, which equilibrate with the lattice via electron-phonon coupling. The increase in lattice temperature is manifested as a strain that can be measured with X-ray diffraction. The diffracted X-ray signal from the excited sample was measured using a streak camera. The amoun

Aim To investigate health care improvement team coaching activities from the perspectives of coachees, coaches and unit leaders in two national improvement collaboratives. Background Despite numerous methods to improve health care, inconsistencies in success have been attributed to factors that include unengaged staff, absence of supportive improvement resources and organisational inertia. Metho

Identifying environmental factors that structure intraspecific genetic diversity is of interest for both habitat preservation and biodiversity conservation. Recent advances in statistical and geographical genetics make it possible to investigate how environmental factors affect geographic organisation and population structure of molecular genetic diversity within species. Here we present a study o

Many alloys undergo complex changes in local chemistry in the vicinity of weldments due to the thermal excursion during welding. The resulting changes in solute concentrations can lead to significant local variations in the unstrained unit cell parameter which, if not accounted for, can lead to serious error when determining residual stress by diffraction methods. Age-hardening aluminium alloys ar

Objective: A disturbed glucose metabolism has been observed in patients with aggressive behaviour. Interleukin (IL)-1β is a pro-inflammatory cytokine that can induce hypoglycaemia, but has also been suggested to be involved in the generation of hostility and aggression. Our group has previously shown an altered glucose metabolism in patients with self-inflicted aggressive behaviour. We investigat

Objectives Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component. Methods A meta-analysis was performed of four genome-wide asso

Popular Abstract in Swedish Avhandlingen handlar om vetenskaplig osäkerhet i policyprocessen, det vill säga när vetenskaplig kunskap om en fråga saknas eller den existerande kunskapen är osäker. Studiens huvudsyfte är att förstå om och hur vetenskaplig osäkerhet påverkar policyprocessen. För att undersöka detta har utvecklingen av den svenska klimatpolitiken från 1975 fram till 2007 studerats. MatThe dissertation is about scientific uncertainty in the policy process, that is when scientific knowledge about an issue is lacking or the existing knowledge is uncertain. The aim of the study is to understand if and how scientific uncertainty affects the policy process. For that purpose, the development of climate change policy in Sweden is studied, from 1975 until 2007. The material studied cons

In sustainability research and elsewhere the notion of resilience is attracting growing interest and causing heated debate. Those focusing on resilience often emphasize its potential to bridge, integrate, and unify disciplines. This paper attempts to evaluate these claims. Resilience is investigated as it appears in several fields, including materials science, psychology, ecology, and sustainabili

Recent findings have shown that the physiological functions of the hormone aldosterone go far beyond its well-known role in blood-pressure regulation and salt/water homeostasis. Aldosterone is for example involved in the regulation of inflammation, and also binds directly to mineralocorticoid receptors in specific brain regions. Interestingly, depressive symptoms appear to correlate with alteratio

On city fires in Sweden.

Steep-slope devices, such as tunnel field-effect transistors (TFETs), have recently gained interest due to their potential for low power operation at room temperature. The devices are based on inter-band tunneling which could limit the on-current since the charge carriers must tunnel through a barrier to traverse the device. The InAs/GaSb heterostructure forms a broken type II band alignment wh

Haemodilution and hypothermia induce coagulopathy separately, but their combined effect on coagulation has not been widely studied. Fibrinogen concentrate can correct dilutional coagulopathy and has an additional effect when combined with factor XIII concentrate. However, their effect on dilutional coagulopathy concomitant with hypothermia has not been studied previously. Free oscillation rheometr

How do we defend ourselves against pathogenic microbes and other parasites infecting us? Research on defence against parasites has traditionally focused on resistance-the ability to prevent infection or limit parasite replication. The genetics, physiology, and evolutionary ecology of such traits are now relatively well understood. During the last few years it has been realized that another, concep

BACKGROUND: There was a decrease 1982-2001 in smoking during early pregnancy in Swedish women. We sought to determine whether there was a parallel decrease in socio-economic inequality in smoking. METHODS: Registry data indicating educational level and smoking status at first antenatal visit in all 2,022,469 pregnancies in Sweden 1982-2001 was analysed. Prevalence differences, odds ratios based on