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European consumer price indices since 1870

Artikeln presenterar en databas med förmodligen de mest aktuella och tillförlitliga konsumentprisindexen (KPI) för ett stort urval av europeiska länder sedan 1870. Databasen utgör i huvudsak en sammanställning av existerande index men är ett bidrag genom att gå tillbaka till ursprungliga eller ignorerade källor. För vissa länder, där KPI saknats, konstrueras nya provisoriska index och vissa index This article presents a database with the probably most up-to-date and reliable consumer price indices for a large sample of European countries since 1870. The database is a compilation but a contribution by going back to original or ignored works. For some countries, where CPIs have been missing, new provisional indices are constructed, and some are reconstructed for critical periods. The article

How policy can strengthen (multi-employer) collective bargaining in Europe: Sweden

With the European minimum wage directive adopted in 2022, all European countries will be obliged to protect and promote collective bargaining. Where collective bargaining coverage is below 80 per cent, they will be obliged to draw up and implement national action plans in 2025 to increase coverage. This will be the first time in history for so many European countries to be legally obliged to thinkWith the European minimum wage directive adopted in 2022, all European countries will be obliged to protect and promote collective bargaining. Where collective bargaining coverage is below 80 per cent, they will be obliged to draw up and implement national action plans in 2025 to increase coverage. This will be the first time in history for so many European countries to be legally obliged to think

Reconsidering performance management to support innovative changes in health care services

PurposeA large number of studies indicate that coercive forms of organizational control and performance management in health care services often backfire and initiate dysfunctional consequences. The purpose of this article is to discuss new approaches to performance management in health care services when the purpose is to support innovative changes in the delivery of services.Design/methodology/a

CSMD1 regulates brain complement activity and circuit development

Complement proteins facilitate synaptic elimination during neurodevelopmental pruning, but neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 (CSMD1) can regulate complement activity in vitro, is expressed in the brain, and is associated with increased schizophrenia risk. Beyond this, little is known about CSMD1 including whether it regulates complement activity

Genomic alterations in ovarian endometriosis and subsequently diagnosed ovarian carcinoma

STUDY QUESTION: Can the alleged association between ovarian endometriosis and ovarian carcinoma be substantiated by genetic analysis of endometriosis diagnosed prior to the onset of the carcinoma?SUMMARY ANSWER: The data suggest that ovarian carcinoma does not originate from ovarian endometriosis with a cancer-like genetic profile; however, a common precursor is probable.WHAT IS KNOWN ALREADY: End

Neurophysiological treatment effects of mesdopetam, pimavanserin and clozapine in a rodent model of Parkinson's disease psychosis

Psychosis in Parkinson's disease is a common phenomenon associated with poor outcomes. To clarify the pathophysiology of this condition and the mechanisms of antipsychotic treatments, we have here characterized the neurophysiological brain states induced by clozapine, pimavanserin, and the novel prospective antipsychotic mesdopetam in a rodent model of Parkinson's disease psychosis, based on chron

Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas

BACKGROUND: The complement inhibitor CSMD1 acts as a tumor suppressor in various types of solid cancers. Despite its high level of expression in the brain, its function in gliomas, malignant brain tumors originating from glial cells, has not been investigated.METHODS: Three cohorts of glioma patients comprising 1500 patients were analyzed in our study along with their clinical data. H4, U-118 and

Preclinical evaluation of zoledronate using an in vitro mimetic cellular model for breast cancer metastatic bone disease

Background The interactions between metastatic breast cancer cells and host cells of osteoclastic lineage in bone microenvironment are essential for osteolysis. In vitro studies to evaluate pharmacological agents are mainly limited to their direct effects on cell lines. To mimic the communication between breast cancer cells and human osteoclasts, a simple and reproducible cellular model was establ

The prognostic and potentially immunomodulatory role of cartilage oligomeric matrix protein in patients with gastric and esophageal adenocarcinoma

BACKGROUND: Cartilage oligomeric matrix protein (COMP) is a novel regulator of the tumor microenvironment. Studies in colon cancer and pancreatobiliary adenocarcinoma have revealed COMP expression to be associated with decreased infiltration of immune cells in the tumor microenvironment. Herein, the expression of COMP was investigated in gastric and esophageal adenocarcinoma with particular refere

Caveolin-1 gene expression provides additional prognostic information combined with PAM50 risk of recurrence (ROR) score in breast cancer

Combining information from the tumor microenvironment (TME) with PAM50 Risk of Recurrence (ROR) score could improve breast cancer prognostication. Caveolin-1 (CAV1) is a marker of an active TME. CAV1 is a membrane protein involved in cell signaling, extracellular matrix organization, and tumor-stroma interactions. We sought to investigate CAV1 gene expression in relation to PAM50 subtypes, ROR sco

Synthesis of square planar complexes for potential antimalarial therapeutics

Malaria is an infectious disease that causes death and illness in the world. The effectiveness of antimalarial drugs like chloroquine has decreased, leading to an increase in the use of organometallic complexes to treat malaria. Ferroquine is an organometallic compound that is a newly developed antimalaria drug that contains a 4-aminoquinoline unit that is coordinated to ferrocene. Eight new metal

Identification of microbial pathogens in Neolithic Scandinavian humans

With the Neolithic transition, human lifestyle shifted from hunting and gathering to farming. This change altered subsistence patterns, cultural expression, and population structures as shown by the archaeological/zooarchaeological record, as well as by stable isotope and ancient DNA data. Here, we used metagenomic data to analyse if the transitions also impacted the microbiome composition in 25 M

Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner

While excessive production of reactive oxygen species (ROS) is a characteristic hallmark of numerous diseases, clinical approaches that ameliorate oxidative stress have been unsuccessful. Here, utilizing multi-omics, we demonstrate that in cardiomyocytes, mitochondrial isocitrate dehydrogenase (IDH2) constitutes a major antioxidative defense mechanism. Paradoxically reduced expression of IDH2 asso

Position of the single-particle 3/2 state in 135Sn and the N=90 subshell closure

The decay of excited states of the nucleus 135Sn, with three neutrons outside the doubly-magic 132Sn core, was studied in an experiment performed at the Radioactive Isotope Beam Factory at RIKEN. Several γ rays emitted from excited 135Sn ions were observed following one-neutron and one-neutron-one-proton removal from 136Sn and 137Sb beams, respectively, on a beryllium target at relativistic energi

Correlation of mitochondrial respiration in platelets, peripheral blood mononuclear cells and muscle fibers

There is a growing interest for the possibility of using peripheral blood cells (including platelets) as markers for mitochondrial function in less accessible tissues. Only a few studies have examined the correlation between respiration in blood and muscle tissue, with small sample sizes and conflicting results. This study investigated the correlation of mitochondrial respiration within and across

Evolutionary model for glacial lake-outburst fans at the ice-sheet front : Development of meltwater outlets and origins of bedforms

Large-scale landforms originated from jökulhlaups or glacial lake-outburst floods (GLOFs), and their small-scale components help in recognising the sedimentary environment of the flood. The GLOF fans that developed along the Pleistocene ice-sheet margin have not been investigated in detail, and north-eastern Poland, with its Megaflood Landform System and Bachanowo and Szeszupka fans, seems ideal f

Introducing Continuous Selective Testing of Evolving Software Version 0.2

In today's evolutionary development of software, continuous testing is needed to ensure that the software is still functioning after changes. Test automation helps partly managing the large number of executions needed, but there is also a limit for how much automated tests may be executed. Then systematic approaches for test selection are needed also for automated tests. This manuscript defines th

Insect genomics : A lousy fly

The bee louse (Braula coeca) is a honeybee inquiline and a long-standing taxonomic mystery. A new study unravels their genomic architecture and shows that these enigmatic flies have evolved from scale insect-exploiting drosophilid ancestors and share genetic similarities with their honeybee hosts.