The interaction between a low angle grain boundary in front of a crack tip and the emerging plasticity from the tip of a microstructurally short edge crack subjected to fatigue loading has been studied. The modeling rests solely on discrete dislocations, were the geometry is described by dislocation dipole elements in a boundary element approach and the plasticity, restricted to one slip plane, to

Short fatigue cracks are known to have a growth behaviour different from that of long cracks, the latter well predicted by linear elastic fracture mechanics. Short cracks can grow at high rates at load levels well below the threshold value for long cracks, before entering into the long crack region, or arrest and become nonpropagating cracks. The growth behaviour of short cracks is strongly influe

Grandparents’ involvement in their adult children’s families has increased in recent decades, especially in relation to care arrangements around grandchildren. This ‘new army of proxy parents’ calls for the need to critically analyse grandparental care. Drawing on a study on intergenerational care in Sweden, involving grandparents, adult children and grandchildren (63 interviewees including 28 graGrandparents’ involvement in their adult children’s families has increased in recent decades, especially in relation to care arrangements around grandchildren. This ‘new army of proxy parents’ calls for the need to critically analyse grandparental care. Drawing on a study on intergenerational care in Sweden, involving grandparents, adult children and grandchildren (63 interviewees including 28 gra

It is well known that the behaviour of short cracks differs from that of long cracks due to the relatively large plastic zone and strong influence from the surrounding microstructure, and for very low growth rates, it is important to account for discrete dislocations within the material. In this study, a discrete dislocation model is presented for the study of the growth behaviour of a short edge

Neuroblastoma exhibits two cellular phenotypes: therapy-sensitive adrenergic (ADRN) and therapy-resistant mesenchymal (MES). To understand treatment response, it is important to elucidate how these phenotypes impact the dynamics of cancer cell populations and whether they represent distinct cell types or dynamic cell states. Here, we use an integrated experimental and mathematical modeling approac

Background: High breast density is an independent risk factor for breast cancer and decreases the sensitivity of mammography. This systematic review synthesizes the international clinical guidelines and the evidence base for screening and supplemental screening recommendations in women with dense breasts. Methods: A systematic search of CINHAL, Embase, and Medline databases was performed in August

Understanding wildlife stakeholders is vital in mitigating the risk for inertia in the implementation of management and illegal activities, e.g., poaching. We used a unique set of questionnaire data of stakeholders in Sweden (n = 8728) comprising birdwatchers, hunters, farmers, and the general public, to analyze evaluations of geese, beliefs about goose management at multiple levels, and acceptanc

This chapter reflects on the need for a decolonial turn in Sweden’s foreign policy. The growing ecological emergencies that we are faced with call on us to recognise and address quite profound global inequities, many of which are rooted in histories of European colonialism. In a sprawling conversation about the coloniality of the global economy and Sweden’s role in it, the chapter addresses such t

A people-centred approach for designing large-scale built-up spaces necessitates systematic anticipation of user’s embodied visuo-locomotive experience from the viewpoint of human-environment interaction factors pertaining to aspects such as navigation, wayfinding, usability. In this context, we develop a behaviour-based visuo-locomotive complexity model that functions as a key correlate of cognit

Climate modeling suggests that achieving international climate goals requires a reduction in current CO2 emissions by over 90%, with any remaining emissions to be addressed through carbon dioxide removal (CDR) solutions. Sixteen CDR strategies are evaluated by integrating technical potential, environmental, social, and governance (ESG) criteria, along with sequestration permanence. This evaluation

Patients with aortic root abscesses experience increased morbidity and mortality compared to those without abscess in aortic valve infective endocarditis. The superior intervention for patients with aortic root abscess is not determined. This research investigates the degree to which increased morbidity and mortality of aortic root abscess, and to describe perioperative characteristics and outcome

Background: The spread of tau pathology closely correlates with the disease course and cognitive decline in Alzheimer’s disease (AD). Tau-targeting immunotherapies are being developed to stop the spread of tau pathology and thus halt disease progression. In this post hoc analysis of the ADAMANT clinical trial, we examined the performance of AADvac1, an active immunotherapy targeting the microtubul

Lipid storage myopathies are considered inborn errors of metabolism affecting the fatty acid metabolism and leading to accumulation of lipid droplets in the cytoplasm of muscle fibers. Specific diagnosis is based on investigation of organic aids in urine, acylcarnitines in blood and genetic testing. An acquired lipid storage myopathy in patients treated with the antidepressant drug sertraline, a s

Body dysmorphic disorder (BDD) is a relatively common and highly impairing mental disorder that is strikingly underdiagnosed and undertreated in Child and Adolescent Mental Health Services (CAMHS). The only clinical guidelines for the management of BDD in youth were published nearly 20 years ago, when empirical knowledge was sparse. Fortunately, there has been a surge in research into BDD over the

The Covid-19 pandemic significantly influenced public discourse, particularly on the use of face masks, with social media serving as a platform for the public to express their opinions and share experiences. This study examines how the Swedish public supports their arguments when discussing their stance on face masks during the Covid-19 pandemic, split into three categories: (1) personal opinions,