The L1 protuberance of the 50S ribosomal subunit is implicated in the release/disposal of deacylated tRNA from the E site. The apparent mobility of this ribosomal region has thus far prevented an accurate determination of its three-dimensional structure within either the 50S subunit or the 70S ribosome. Here we report the crystal structure at 2.65 Å resolution of ribosomal protein L1 from Sulfolob

Ja visst gör det ont när kommunala mål brister, …åtminstone om vi får tro andemeningen i de nya texterna avseende god ekonomisk hushållning som återfinns i kommunallagen och lagen om kommunal redovisning. Som bekant skall budgetens planer för verksamhet och ekonomi numera innehålla mål och riktlinjer och utvärdering av målen skall ske i årsredovisningens förvaltningsberättelse, allt i syfte att st

Elements emitted to the atmosphere are partly exported to more remote areas and contribute to the regional and territorial deposition rates. This study is based on the principle that carpet-forming bryophytes (pleurocarpic mosses) absorb elements and particles from rain, melting snow and dry deposition. We compare the concentrations of 60 elements in carpets of the forest moss Pleurozium schreberi

We obtain an existence theorem for monotone positive solutions of nonlinear second-order ordinary differential equations by using the Schauder-Tikhonov fixed point theorem. The result can also be applied to prove the existence of positive solutions of certain semilinear elliptic equations in R-n (n greater than or equal to 3).

It has been previously suggested that leukotriene-induced Ca2+ signalling is mediated through a Rho-dependent process, but neither direct activation of Rho nor a mechanism underlying such signalling has been reported. Accordingly, we used the Rhotekin binding assay to assess RhoA activation in intestinal epithelial cells and observed that RhoA was activated by leukotriene D4 (LTD4). We also found

A 12-year-old girl with multifocal skeletal sclerosis has been investigated. She was BCG vaccinated at birth and developed regional lymphadenitis in her left groin at two months of age. She was healthy until approximately 10 years of age, after which deficient height and weight gain occurred. BCG-itis was diagnosed in skeleton lesions. No evidence of immunodeficiency was found in the patient. Afte

A search for isomeric states was performed in the nucleus Nd-140(60)80 using in-beam gamma-ray spectroscopy and the Te-126(O-18,4n) reaction. Prompt and delayed gamma-ray coincidences were measured with the AFRODITE spectrometer using the pulsed beam delivered by the Separated Sector Cyclotron of iThemba LABS. One new isomer was identified, with spin-parity I-pi=20(+) and lifetime T-1/2 >= 400 ns,

It is commonly believed that high-quality CdTe nanoparticles with strong luminescence can only be prepared under the protection of an inert gas such as nitrogen or argon. Here, we report the preparation of highly luminescent CdTe nnaoparticles in air and compare their luminescence properties with CdTe nanoparticles made in nitrogen. We find that both water-soluble CdTe nanoparticles made in air an

The main objective of this PhD thesis, "An Aesthetics of Sexual Difference? On Art and Artistry in Swedish Handicraft of the 1920s and 1990s", is to investigate the field of handicraft in relation to a wider field of cultural production. Its aim is to contribute to a mapping of interrelated outlines of handicraft and art based on empirical studies of artistic creation in two local Swedish handicra

Popular Abstract in SwedishAvhandlingen syftar till att studera svenska föreställningar om USA och det amerikanska och genom dem den svenska självbilden och olika visioner om den svenska framtiden i den offentliga debatten under perioden c:a 1900-1939, då USA var omdiskuterat som en mycket betydelsefull ny nation men ännu inte erkänt som en obestridlig supermakt. Den söker visa hur föreställningarThe aim of this thesis is to study Swedish notions of the USA and of things American and through them the Swedish self-image and the ideas about the Swedish future as seen in public debate in the period c. 1900-1939, when the USA was the subject of a good deal of discussion as an up-and-coming nation of great importance but was not yet recognized as an indisputable super power. It tries to demonst

We present and analyze low-rank channel estimators for orthogonal frequency-division multiplexing (OFDM) systems using the frequency correlation of the channel. Low-rank approximations based on the discrete Fourier transform (DFT) have been proposed, but these suffer from poor performance when the channel is not sample spaced. We apply the theory of optimal rank-reduction to linear minimum mean-sq

A systems analysis approach was used to assess farmscale nutrient and trace element sustainability by combining full-scale field experiments with specific studies of nutrient release from mineral weathering and trace-element cycling. At the Ojebyn dairy farm in northern Sweden, a farm-scale case study including phosphorus (P), potassium (K), and zinc (Zn) was run to compare organic and conventiona

Neutrophils migrate to infected mucosal sites that they protect against invading pathogens. Their interaction with the epithelial barrier is controlled by CXC chemokines and by their receptors. This study examined the change in susceptibility to urinary tract infection (UTI) after deletion of the murine interleukin 8 receptor homologue (mIL-8Rh). Experimental UTIs in control mice stimulated an epi

The hindered diffusion and binding of proteins of different sizes (lysozyme, BSA and IgG) in an agarose gel is described using adsorption kinetic and diffusional data together with an experimentally determined pore size distribution in the gel. The validity of the pore model, including variable diffusion coefficients and porosities is tested against experimental confocal microscopy data. No fittin

We studied the A-band photodissociation of bromoiodomethane, CH2BrI, in acetonitrile solution at room temperature by femtosecond pump-probe spectroscopy, Initiated by the 266 nm light, this reaction leads to the CH2Br-I isomer, most likely produced via in-cage recombination of the CH,Br and I photofragments. The isomer is formed vibrationally excited with a time constant of similar to7.5 ps and th

Objectives. Infliximab is an anti-tumour necrosis factor-alpha (TNF-alpha) mousehuman IgG1/k antibody used to treat patients with rheumatoid arthritis (RA) and other inflammatory diseases. Unfortunately, response failure and side-effects due to immunogenicity of the drug are not rare. In this study, we have compared different methods of assessing drug levels and anti-infliximab antibodies (Abs) an