Why do cockroaches and rats survive in sewers and other extremely challenging conditions? The answer is that through evolution they have been equipped with antimicrobial peptides (AMPs) that protect them from microbiological insult. In the case of cockroaches and rats, the AMPs are very potent, allowing for these challenging environments [1–3]. AMPs are the most ancient and primitive arm of the hu

Three-dimensional Large Eddy Simulations (LES) are conducted on a non-premixed hydrogen-air annular rotating detonation combustor (RDC). A 22-step finite-rate chemistry reaction mechanism and a flow solver previously developed for high-speed reacting flow are used to perform the LES’. The selected case is an RDC designed by the US Air Force Research Laboratory and has been studied experimentally a

With increased autonomy in marine vessels, autonomous surface vessels (ASVs) and conventionally manned vessels need to coexist at sea. Any relocation needs to include collision avoidance according to the traffic rules at sea, COLREGs. Here, a local collision-avoidance planner for an archipelago environment is presented. The optimization-based local planner presented considers a predefined nominal

It is clear from the subfossil record that aurochs (Bos primigenius) and European bison (Bison bonasus) coexisted in southern Scandinavia during the late Pleistocene and early Holocene. However, the two species are unevenly represented, especially in zooarchaeological assemblages where the aurochs is the only identified bovine. By applying genetic taxonomic assignment from mitochondrial and shallo

PurposeThis study investigates how global retailers develop sustainability through network interactions that influence institutionalized sustainability perceptions. The findings enable retailers to drive sustainability systematically and understand the critical internal and external issues.Design/methodology/approachThe study investigates how retailers can work to increase support for sustainabili

Our current historical moment is marked by a widespread sense of (ongoing and anticipated) crises, prompting calls to change existing economic, political, social, and environmental systems. This discourse has directed increased scholarly and policy-orientated attention to the concepts of “transformation” and “resilience.” However,beyond attention, these concepts have increasingly adopted a place iOur current historical moment is marked by a widespread sense of (ongoing and anticipated) crises, prompting calls to change existing economic, political, social, and environmental systems. This discourse has directed increased scholarly and policy-orientated attention to the concepts of “transformation” and “resilience.” However, beyond attention, these concepts have increasingly adopted a place

BACKGROUND: Currently, there are few treatment-predictive and prognostic biomarkers in triple-negative breast cancer (TNBC). Caveolin-1 (CAV1) is linked to chemoresistance and several important processes involved in tumor progression and metastasis, such as epithelial-mesenchymal transition (EMT). Herein, we report that high CAV1 gene expression is an independent factor of poor prognosis in TNBC.M

We investigated the role of phosphorus (P) impurities on the fracture toughness and underlying failure mechanisms by means of classical atomistic modeling for a set of ⟨110⟩ symmetric tilt tungsten grain boundaries (GBs). This entailed the utilization of a quasi-static mode I displacement-controlled setup with cohesive zone volume elements (CZVEs) to study failure mechanisms and evaluate the fract

Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer's disease (AD) patients, are prevalent and clinically meaningful in this group of older adults. To uncover distinct atrophy subtypes, we applied the Subtype and Stage Infer

High-quality diets have been increasingly acknowledged as a promising candidate to counter the growing prevalence of mental health disorders. This study aims to investigate the prospective associations of adhering to the EAT-Lancet reference diet with incident depression, anxiety and their co-occurrence in 180,446 UK Biobank participants. Degrees of adherence to the EAT-Lancet diet were translated

Studier pekar på att en förbättrad mitokondriefunktion kan motverka åldrande generellt och parodondalt.