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hEP4-R (human prostaglandin E2 receptor, subtype EP4) is a Gs-linked heterotrimeric GPCR (G-protein-coupled receptor). It undergoes agonist-induced desensitization and internalization that depend on the presence of its C-terminal domain. Desensitization and internalization of GPCRs are often linked to agonist-induced b-arrestin complex formation, which is stabilized by phosphorylation. Subsequentl

The effect of the non-ionic contrast medium iohexol (Omnipaque) on renal function was investigated in diabetic patients with signs of peripheral ischaemia. Forty-six patients, 70 +/- 11 years (mean +/- SD) old, age at diabetes diagnosis 53 +/- 17 years, and with varying degrees of diabetic nephropathy were studied before 1, 2, and 30 days after aortobifemoral arteriography. Serum creatinine, creat

Spectroscopic radial velocities for several nearby open clusters suggestthat spectra of (especially earlier-type) rapidly rotating stars aresystematically blueshifted by 3 km s^-1 or more, relative tothe spectra of slowly rotating ones. Comparisons with astrometricallydetermined radial motions in the Hyades suggests this to be an absoluteblueshift, relative to wavelengths naively expecte

Lifetime tests of solar reflector materials are eligible prior to application, to prove the stability of the optical properties. In this work, six reflector materials were aged outdoors and in a climatic test chamber. The surfaces of the samples were inspected using profilometry and optical microscopy. The total and specular reflectance spectra were measured using spectrophotometry and the weighte

BACKGROUND: Cancer prevalence-the proportion of people in a population with a diagnosis of cancer-includes groups with widely differing cancer care needs. We estimated the proportions of the prevalent colon cancer cases requiring initial care, terminal care and follow-up. PATIENTS AND METHODS: Prevalence by year since diagnosis was estimated from incidence and vital status data on 243,471 colon ca

Changes in physical activity with the aim of increasing energy expenditure are usually an important component of childhood obesity treatment. Physical activity also has several other aspects that are positive for the obese child's health, such as improving the metabolic profile and psychological well being. The aim of this paper is to give a short review of what we know about physical activity in

Artikeln presenterar det stora forskningsprojektet med samma namn.

As the risks generated by industry and other organisations in society change, requirements as to how these risks are to be managed must change correspondingly. This means that new methods and techniques of risk analysis and management must be developed. The need for effective research and education in this area is accentuated by the rapid pace of organisational and technological change leading to

The mirror nuclei Mg-25 and Al-25 are expected to have very similar structures. The Gamow-Teller (GT) transitions from the J(pi) = 5/2(+) ground state of Mg-25 to the excited states in Al-25 were studied by high-resolution measurements of the Mg-25(He-3,t) charge-exchange reaction at 0degrees and at 140 MeV/nucleon. Assuming the usual DeltaJ(pi) = 1(+) selection rule for the spin-isospin-type GT t

We have studied the effect of electron-phonon interaction on the electronic transport in a one-dimensional wire where both electrons and phonons are quantum confined. We found substeps appeared in the quantized electron conductance, and the step height depends on the electron-phonon coupling strength. With increasing temperature, the substep structure smooths out. Dependent on the transmission pro