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The stability toward thermal and urea denaturation was measured for HAMLET (human -lactalbumin made lethal to tumor cells) and -lactalbumin, using circular dichroism and fluorescence spectroscopy as well as differential scanning calorimetry. Under all conditions examined, HAMLET appears to have the same or lower stability than -lactalbumin. The largest difference is seen for thermal denaturation o
In this work, the problem of designing feedback controllers for the rejection of narrow-band disturbances is considered. The design technique proposed herein is based upon the overparameterization of a nominal minimum-variance controller, which is designed by means of an ARMA model of a sinusoid in noise. The extra degrees of freedom so introduced are used to improve the robustness of the nominal
Objective. Human papilloma virus (HPV) testing and repeat cytology are both proposed as methods to triage women with minor cytological cervical lesions. By triage, those women can be identified who need referral for diagnostic exploration with colposcopy and/or biopsy. Methods. We conducted meta-analyses of reported studies on the accuracy to detect high-grade cervical intra-epithelial neoplasia o
While several techniques exist for assessing quantitative differences among proteomes representing different cell states, methods for assessing how these differences are mediated are largely missing. We present a method that allows one to differentiate between cellular processes, such as protein synthesis, degradation and PTMs which affect protein concentrations. An induced systemic perturbation o
A stable numerical algorithm is presented for an elastostatic problem involving a crack close to and in front of an inclusion interface. The algorithm is adaptive and based on an integral equation of Fredholm’s second kind. This enables accurate analysis also of rather difficult situations. Comparison with stress intensity factors of cracks close to straight infinite bimaterial interfaces are made
Chemosensory stimuli play a crucial role for host selection in insects, including the fruit fly Drosophila melanogaster[1]. Drosophila has been instrumental in unraveling the neurological basis of olfactory processing in insects [2]. Basic knowledge regarding chemical ecology and thorough studies of olfactory preferences are still lacking to a great extent in D. melanogaster, however. We have char
Endosymbiotic bacteria of aphids, Buchnera aphidicola, and tsetse flies, Wigglesworthia glossinidia, are descendents of free-living gamma-Proteobacteria. The acceleration of sequence evolution in the endosymbiont genomes is here estimated from a phylogenomic analysis of the gamma-Proteobacteria. The tree topologies associated with the most highly conserved genes suggest that the endosymbionts form
Epoxy alkylstearates were synthesized by lipase catalysed esterification and perhydrolysis followed by epoxidation of oleic acid in a one-pot process. Immobilized Candida antarctica lipase (Novozym 435) was used as the catalyst. The esterification reaction occurred relatively quickly and was followed by epoxidation of the alkyl ester and the remaining fatty acid. Higher degree of esterification wa
BACKGROUND: Metabolic syndrome (MS) is a common health problem in menopausal women. According to The Adult Treatment Panel (ATP) III, MS includes the combination of three or more of the following risk factors: abdominal obesity, glucose intolerance, high blood pressure, high serum triglycerides and low levels of high density lipoprotein cholesterol. OBJECTIVES: To assess the prevalence of the MS i
ATP-sensitive potassium (K-ATP) channels play an important role in the regulation of cerebral vascular tone. In vitro studies using synthetic K-ATP channel openers suggest that the pharmacological profiles differ between rat basilar arteries and rat middle cerebral arteries. To address this issue, we studied the possible involvement of endothelial K-ATP channels by pressurized arteriography after
The relation between the atrioventricular conduction properties of the atrioventricular node and the anterograde conduction ability over the accessory pathway in the Wolff-Parkinson-White syndrome has never been studied. Atrioventricular nodal characteristics were studied in 285 patients with manifest and 204 with concealed accessory pathway who underwent radiofrequency ablation, and compared with
A surface with periodic corrugations of sufficiently small periodicity is shown to be electromagnetically equivalent to an inhomogeneous transition region (slab). Explicit expressions for the inhomogeneous transition region are found for one-dimensional corrugations and for two-dimensional corrugations a local elliptic problem has to be solved in order to find the equivalent electromagnetic propertie
Purpose. To gain an understanding of how women with spinal cord injury ( SCI) experienced human encounters in occupations and how these influenced their participation. Method. The data were collected through two or three in- depth interviews with 13 women ( age 25 - 61 years) with SCI. Data analysis was carried out by using a paradigmatic analysis of narrative data, followed by an interpretation b
We have used density functional methods to calculate fully relaxed potential energy curves of the seven lowest electronic states during the binding of O-2 to a realistic model of ferrous deoxyheme. Beyond a Fe-O distance of similar to 2.5 Angstrom, we find a broad crossing region with five electronic states within 15 kJ/mol. The almost parallel surfaces strongly facilitate spin inversion, which is
