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A BRCA2 mutation incorrectly mapped in the original BRCA2 reference sequence, is a common West Danish founder mutation disrupting mRNA splicing

Inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose carriers to breast and ovarian cancer. The authors have identified a mutation in BRCA2, 7845+1G > A (c.7617+1G > A), not previously regarded as deleterious because of incorrect mapping of the splice junction in the originally published genomic reference sequence. This reference sequence is generally used in many laborator

Current trends in stroke rehabilitation. A review with focus on brain plasticity.

Johansson BB. Current trends in stroke rehabilitation. A review with focus on brain plasticity. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2010.01417.x. (c) 2010 John Wiley & Sons A/S. Current understanding of brain plasticity has lead to new approaches in ischemic stroke rehabilitation. Stroke units that combine good medical and nursing care with task-oriented intense training in an environm

Bond Breaking, Electron Pushing, and Proton Pulling: Active and Passive Roles in the Interaction between Aqueous Ions and Water as Manifested in the O 1s Auger Decay

A core-ionized H(2)O molecule in liquid water primarily relaxes through normal Auger decay, leading to a two-hole final state in which both valence holes are localized on the same water molecule. Electronic coupling to the environment, however, allows for alternative decays resembling Intermolecular Coulombic Decay (ICD), producing final states with one of the holes delocalized on a neighboring wa

Mapped Bodies : Notes on the Use of Biometrics in Geopolitical Contexts

“Mapped Bodies: Notes on the Use of Biometrics in Geopolitical Contexts” examines the role played by automated biometric technologies in migration control and in the so-called war on terror. Biometric methods such as automated fingerprint identification, iris scanning and facial recognition record microscopic bodily characteristics, computes patterns from them, and matches those patterns against a

Lesion size affects diagnostic performance of IOTA logistic regression models, IOTA simple rules and risk of malignancy index in discriminating between benign and malignant adnexal masses

Objectives To estimate the ability to discriminate between benign and malignant adnexal masses of different size using: subjective assessment, two International Ovarian Tumor Analysis (IOTA) logistic regression models (LR1 and LR2), the IOTA simple rules and the risk of malignancy index (RMI). Methods We used a multicenter IOTA database of 2445 patients with at least one adnexal mass, i.e. the dat

Latin Letters from Clergymen in the Province of Scania (Eastern Denmark - Southern Sweden) in the Seventeenth Century : A Critical Edition with Introduction, Translation and Commentaries

This doctoral thesis comprises a critical edition of a previously unpublished manuscript from the late seventeenth century, which is housed in Lund University Library. The manuscript consists of copies of eighty-eight letters and other documents in Latin. The originals were, in most cases, written by country vicars from Scania, a Swedish province that until 1658 was part of Denmark. The identity o

Perfect or Imperfect Learning : Teaching the "Tenses" of Biblical Hebrew

The article discusses the pedagogical challenges inherent in teaching the “tenses” of Biblical Hebrew. How does one cope with explaining the intricacies and scholarly uncertainties of this question to beginners – and to what level is it advisable to do so? The author also examines the possible benefits of imparting a deeper understanding of these issues beyond the domain of the classroom.

Occupational Accidents Among Elderly Farmers in Sweden

The workforce in many countries nowadays is becoming older due to demographic change. Compared with many other occupations, farmers often work until a higher age. This study analysed occupational accidents to farmers in Sweden from an age perspective using data on 223 work injuries on farms and 990 road accidents involving tractors. The results showed that older farmers were not significantly more

Improving simultaneous saccharification and co-fermentation of pretreated wheat straw using both enzyme and substrate feeding.

ABSTRACT: BACKGROUND: Simultaneous saccharification and co-fermentation (SSCF) has been recognized as a feasible option for ethanol production from xylose-rich lignocellulosic materials. To reach high ethanol concentration in the broth, a high content of water-insoluble solids (WIS) is needed, which creates mixing problems and, furthermore, may decrease xylose uptake. Feeding of substrate has alre

Directional analysis of measured 60 GHz indoor radio channels using SAGE

Abstract in Undetermined Directional properties of the radio channel are of high importance for the development of reliable wireless systems operating in the 60 GHz frequency band. Using transfer functions measured from 61 to 65 GHz in a conference room we have extracted estimates of the multi-path component parameters using the SAGE algorithm. In the paper we compare results for line-of-sight (LO

Impact on image quality and radiation exposure in coronary CT angiography: 100 kVp versus 120 kVp

Background: The risk of radiation-induced cancer has become a major concern with the increasing use of computed tomography (CT). Purpose: To compare image quality and radiation doses when decreasing X-ray tube peak kilovoltage (kVp) from 120 to 100 kVp in patients undergoing coronary CT angiography (CCTA). Material and Methods: Patients referred for evaluation of suspected coronary artery disease

Cavity-enhanced storage-preparing for high-efficiency quantum memories

Cavity-assisted quantum memory storage has been proposed for creating efficient (close to unity) quantum memories using weakly absorbing materials. Using this approach, we experimentally demonstrate a significant (similar to 20-fold) enhancement in quantum memory efficiency compared to the no cavity case. A strong dispersion originating from absorption engineering inside the cavity was observed, w

On General Domain Truncated Correlation and Convolution Operators with Finite Rank

Truncated correlation and convolution operators is a general operator-class containing popular operators such as Toeplitz (Wiener-Hopf), Hankel and finite interval convolution operators as well as small and big Hankel operators in several variables. We completely characterize the symbols for which such operators have finite rank, and develop methods for determining the rank in concrete cases. Such

Nu når vi äntligen Pluto

I juli 2015 når NASA-rymdsonden New Horizons till solsystemets mest kända dvärgplanet Pluto. Denna artikel diskuterar vad Pluto egentligen är och vad rymdsonden kommer att hitta.

Improved forensic DNA analysis through the use of alternative DNA polymerases and statistical modeling of DNA profiles.

DNA evidence, linking perpetrators to crime scenes, is central to many legal proceedings. However, DNA samples from crime scenes often contain PCR-inhibitory substances, which may generate blank or incomplete DNA profiles. Extensive DNA purification can be required to rid the sample of these inhibitors, although these procedures increase the risk of DNA loss. Most forensic laboratories use commerc

Mast cell-associated alveolar inflammation in patients with atopic uncontrolled asthma

Background: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. Objective: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. Methods: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with

The Unified Conceptual Space Theory: An Enactive Theory of Concepts

Theories of concepts address systematically and productively structured thought. Until the Unified Conceptual Space Theory (UCST), based on Peter Gärdenfors’ Conceptual Spaces Theory, no one had attempted to offer an explicitly enactive theory of concepts. UCST is set apart from its competitors in locating concepts not in the mind (or brain) of the conceptual agent nor in the affordances of the ag