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AIMS: Metformin has hitherto not been proven superior to other type 2 diabetes (T2D) medications for the prevention of organ complications. The aim of this study is to report baseline data and blinded interim analyses in the register-based randomised clinical trial (RRCT) SMARTEST, which compares metformin and the SGLT2 inhibitor dapagliflozin in early T2D. We also present learnings from the novel

Background and ObjectivesSpinocerebellar ataxias (SCAs) and other neurodegenerative cerebellar ataxias (N-SCAs) involve alterations in cerebellar structure and function, affecting motor control and sensorimotor integration but also cognitive functions such as visuospatial processing. The cerebellum is essential for sensorimotor functions, and it contributes to cognition. The study aims to assess s

It is predicted that continentality, a climate parameter representative of a region’s annual temperature and precipitation range, will undergo significant changes in the future. The lack of past continentality reconstructions makes it impossible to decipher any long-term patterns of continentality changes. Here, we investigate the extent to which continentality influences modern chironomid assembl

Background Obsessive-compulsive disorder (OCD) is associated with an increased risk of cardiometabolic disorders. We developed a lifestyle intervention, named LIFT, aimed at improving lifestyle habits (physical activity, diet, alcohol and tobacco use, stress, sleep) and reducing cardiometabolic risk factors in OCD. Aims This study aimed to establish the feasibility and acceptability of LIFT, evalu

STUDY QUESTION Which spermatogonial differentiation states are present in prepubertal testes under normal conditions and following chemotherapy-induced depletion of spermatogonia in paediatric patients with cancer? SUMMARY ANSWER Single-cell transcriptomic analysis reveals that only undifferentiated spermatogonia are present in prepubertal boys, while differentiated states emerge during puberty, w

Background: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women. Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry. Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 c

Mechanisms of the aerosol indirect effects (AIEs) from ice nucleating particles (INPs) are investigated with the cloud-resolving “aerosol–cloud” (AC) model with a hybrid bin–bulk microphysics scheme coupled with a radiation scheme in 1) continental deep convection observed during the Midlatitude Continental Convective Clouds Experiment (MC3E) over Oklahoma and 2) supercooled stratiform clouds obse

This thesis explores the potential and limitations of basalt fibre textile in the context of products within the commercial market. Due to its heat insulation capabilities, combined with its fire resistance, durability and eco-friendliness, basalt fibre is currently mostly utilized in construction. Hence, the material itself is rarely visible to the user, but hidden behind drywalls or buried in co

In both second language acquisition research and teaching, there is a need for practical, reliable and valid proficiency tests to be used with learners of various target languages and at different proficiency levels. In the present study, a written proficiency test based on the C-test methodology was developed and tested on 144 Swedish 15-year-olds studying French, German, and Spanish in lower sec

The article analyses strategies developed by Ukrainians who arrived in France since 2022 and who have to deal with the difficult real estate market trying to find a place to live. Going beyond the structuralist framework, the authors investigate subjective motivations and attitudes that combine with structural factors to produce different strategies of adaptation to the French housing market. Thes

Abstract in French:L’article part d’une énigme empirique : le cas d’une usine de petite taille dans une ville industrielle ukrainienne semble contredire tout ce qu’on savait sur le paternalisme industriel et les attitudes contestataires des ouvrier·e·s dans ce pays. Contrairement aux grandes entreprises de la même ville, cette usine jouit de la paix sociale sans avoir à la garantir avec le « salaiThis article begins with an empirical puzzle: the case of a small factory in an industrial Ukrainian city appears to contradict everything we thought we knew about industrial paternalism and workers’ contestatory attitudes in the country. Unlike the large companies in the same city, this factory enjoys social peace without having to guarantee it through a “social wage”. How does management succeed

More than 3500 samples of lichen genus Xanthoria s.l. were collected at 135 localities in the Baltic Sea–Kattegat area during 2022–2025. Of these, 177 were selected for phylogenetic analyses using ITS and mt-sequences. The phylogenetic tree of Xanthoria s.str. reveals 24 clades possibly corresponding to species, six of which are described, i. e. X. calcicola, X. coomae, X. ectaneoides, X. pedersen

This chapter examines the organizational dynamics of social media-based new crisis initiatives that emerged in response to the COVID-19 pandemic, with a particular focus on their communication. Drawing on empirical case studies, the authors explore how these loosely structured grassroots initiatives mobilized resources, coordinated action, and maintained engagement. The study highlights the centra

I år är det 30 år sedan Sverige blev medlem i EU. Därmed är det också 30 år sedan Sverige anslöt sig till EU:s två språkpolitiska mål om lärande av främmande språk och skydd av minoritets- och regionalspråk. Det kan emellertid konstateras att dessa båda mål gått olika öden till mötes i Sverige. Medan minoritetsspråkens ställning har stärkts har hållningen kring främmande språk varit vacklande. Ett

Symmetric informationally complete measurements are both important building blocks in many quantum information protocols and the seminal example of a generalized, non-orthogonal, and quantum measurement. In higher-dimensional systems, these measurements become both increasingly interesting and increasingly complex to implement. Here, we demonstrate an integrated quantum photonic platform, operatin