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Ultra-low Power Design Approaches in Memories and Assist Techniques

The need for more functionality and higher performance has increased the number of transistors to billions in current processors. A high number of transistors on the same chip area increases the power density, which in turn heats up the devices and lowers the life time of batteries. The increasing demand for devices relying on battery and harvested energies in the Internet of Things (IoT) era has

Swelling and Microstructure of Nanoplatelet Systems

De flesta anser nog att kemi och speciellt teoretisk kemi är ett mycket komplext ämne, medan lera nog anses som ett begripligt koncept. Det man kanske inte tänker på är att många leror utgörs till stor del av elektrostatiskt laddade nanopartiklar där dess beteende kan förstås genom just ämnena kemi och teoretisk kemi. De laddade nanopartiklarna, även kallade lerplattor, är formade som tunna pannkaMany clay minerals consist of charged nanoplatelets that swell in an aqueous solution. The swelling and the microstructure depend on the type of clay mineral but are also dependent on, for example, the ionic composition and the temperature of the solution. The synthetic clay mineral Laponite and the natural clay mineral montmorillonite have been studied experimentally and theoretically. The swelli

FK506, an Immunosuppressive Drug, Induces Autophagy by Binding to the V-ATPase Catalytic Subunit A in Neuronal Cells

The drug FK506 (tacrolimus, fujimycin) exerts its immunosuppressive effects by regulating the nuclear factor of the activated T-cell (NFAT) family of transcription factors. However, FK506 also exhibits neuroprotective effects, but its direct target proteins that mediate these effects have not been determined. To identify the target proteins responsible for FK506's neuroprotective effects, the drug

Alternativ arbetsglädje : om lyckokänslor i arbetslivet i skiftet mellan 1970- och 1980-tal

1970-talets känslomönster utmärktes av en dröm om mänsklig gemenskap och befrielse från fördomar samt en vilja att komma i kontakt med sig själv och andra, att söka det äkta, det naturliga, det autentiska och nå en öppenhet. Man ville att det skulle kännas på ett visst sätt att arbeta, vila, skapa, vara solidarisk, konsumera, ha sex, vara barn, förälder, man och kvinna, ung och gammal, överordnad

Drivers and Barriers for Integrated Mobility Services

As more people move to cities and urban areas are growing, demand for urban transport increases. This leads not only to pressure on sustainability and climate goals, but also on the attractiveness and liveability of urban areas. Thus, it is necessary to decrease the use of private cars and create a modal shift towards more sustainable modes of transport, such as walking, cycling and public transpo

Local host specialization, host-switching, and dispersal shape the regional distributions of avian haemosporidian parasites

The drivers of regional parasite distributions are poorly understood, especially in comparison with those of free-living species. For vector-transmitted parasites, in particular, distributions might be influenced by host-switching and by parasite dispersal with primary hosts and vectors. We surveyed haemosporidian blood parasites (Plasmodium and Haemoproteus) of small land birds in eastern North A

Preoperative localization of enlarged parathyroid glands with ultrasonically guided fine needle aspiration for parathyroid hormone assay

For preoperative localization of enlarged parathyroid glands, several imaging techniques have been used. In this study we demonstrate the feasibility of using ultrasonography with fine needle aspiration for parathyroid hormone assay as a preoperative localization procedure in 21 patients with primary hyperparathyroidism. A single adenoma was found in 18 patients while 3 patients had multiglandular

A prospective study of 100 roboticallyassisted laparoscopic adrenalectomies

We evaluated robotically assisted laparoscopic adrenalectomy (RLA) in a prospective study of 100 consecutive patients (60 women and 40 men) undergoing unilateral adrenalectomy at the University Hospital. The median age was 59 (24-82) years and BMI 27.6 (17.1-40.9) kg/m(2). Preoperative diagnoses were Conn's syndrome 30%, pheochromocytoma 23%, Cushing syndrome 27% and non-functional tumor 20%. The

Intraoperative secretion of intact parathyroid hormone and amino-terminal parathyroid hormone fragments from normal parathyroid glands associated with solitary parathyroid adenoma

The nonadenomatous parathyroid glands associated with parathyroid adenoma in patients with primary hyperparathyroidism (pHPT) are assumed to exhibit suppressed secretion of parathyroid hormone (PTH). Because the function of these glands is of clinical importance for calcium homeostasis after surgery for pHPT, we studied the decrease of serum levels associated with intact PTH (i-PTH) and amino-term

Recent advances on CD4+ T cells in atherosclerosis and its implications for therapy

Atherosclerosis is an arterial inflammatory disease and the primary cause of cardiovascular disease. T helper (Th) cells are an important part in atherosclerotic plaque as they can be either disease promoting or protective. A body of evidence points to a pro-atherosclerotic role of Th1 cells, whereas the role of Th2, Th17 and iNKT cells seems more complex and dependent on surrounding factors, incl

Soil organic matter decomposition mechanisms in ectomycorrhizal fungi

In boreal forests, ectomycorrhizal (ECM) fungi are found in soil layers containing decomposed litter and humus-rich soil organic matter (SOM). This chapter summarizes the present understanding of the mechanisms for oxidative decomposition of SOM and the hydrolysis and mobilization of organic N and P sources by ECM fungi. It discusses how these processes may influence the formation and stability of

Divorce and the onset of alcohol use disorder : A Swedish population-based longitudinal cohort and co-relative study

Objective: The purpose of this study was to clarify the magnitude and nature of the relationship between divorce and risk for alcohol use disorder (AUD). Method: In a population-based Swedish sample of married individuals (N=942,366), the authors examined the association between divorce or widowhood and risk for first registration for AUD. AUD was assessed usingmedical, criminal, and pharmacy regi

Experimental Investigation on Effects of Central Air Jet on the Bluff-body Stabilized Premixed Methane-air Flame

Flame stabilized by a bluff-body is a common scene in many engineering applications due to the enhanced mixing characteristics, improved flame stability, and ease of combustion control. We recently designed a burner which has a conical bluff body with a central air injector. In the current work, effects of the central air jet on the heat load of the bluff body, the flame structures and the flame b

Flow-Inducing Networks

We consider flow-inducing networks, a class of models that are well-suited to describe important biochemical systems, including the MAPK pathway and the interactions at the trans-Golgi network. A flow-inducing network is given by the interconnection of subsystems (modules), each associated with a stochastic state matrix whose entries depend on the state variables of other modules. This results in

Spatial Models of Gene Patterns in Plants

Hur utvecklas en växt? Om man studerar växter så upptäcker man ganska snart de många symmetrier och regelbundna former som finns i växtriket. Nya växtorgan såsom löv och blommor bildas ofta i regelbundna mönster, som exempelvis kan ge upphov till de spiraler som kan observeras på en ananas eller kotte. Beroende på frekvensen ochvinklarna mellan de nya organ som skapas, kan olika mönster hos växtenThe growth and development of plants exhibits a striking symmetry, visible in the regular arrangement of leaves and flowers. Plant development is carefully controlled at the molecular level by gene regulatory networks, and the symmetry of plants can be observed also in the molecular patterns of gene expression.This thesis investigates the molecular basis for spatial patterns of gene expression in