Transforming growth factor-beta (TGF-beta) is involved in vascular formation through activin receptor-like kinase (ALK)1 and ALK5. ALK5, which is expressed ubiquitously, phosphorylates Smad2 and Smad3, whereas endothelial cell (EC)-specific ALK1 activates Smad1 and Smad5. Because ALK5 kinase activity is required for ALK1 to transduce TGF-beta signaling via Smad1/5 in ECs, ALK5 knockout (KO) mice w

Objective To investigate whether an adjuvanted pandemic A/H1N1 2009 influenza vaccine in pregnancy was associated with an increased risk of fetal death. Design Nationwide register based cohort study. Setting Denmark. Participants All clinically recognised singleton pregnancies that ended between November 2009 and September 2010. Individual level data on exposure to an inactivated AS03 pandemic A/H

A project on electronic publishing of doctoral dissertations in fulltext started in 1998 at the Lund University Library. Dissertations that consist of a number of articles that have already been published in or submitted to scholarly journals posed a potentional problem with regard to copyright questions. In order to solve this problem, the commersial publishers were approached with a request for

Bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is widely used in the management of patients with osteoporosis. Factors, which are specific to machine or to operator, can influence the accuracy and precision of BMD estimations. We studied the effect of leg rotation by 10 degrees either internally or externally from the standard position in a group of 50 women (average

Background: The W allele of the G460W polymorphism in the adducin-1 gene has been occasionally associated with increased blood pressure (BP). The aim of this study was to test whether the G460W variant is associated with BP levels and BP progression rate and whether G460W associations with BP are affected by sex, body mass index (BMI), or age. Methods: The G460W polymorphism was genotyped in the p

In this paper a statistical forecasting model designed for bounded areas of near-surface ocean wind speeds is implemented. Dimension reduction is achieved by decomposing the covariance structure into one large-scale and one small-scale component using empirical orthogonal functions. The large-scale component is modelled with an AR process and forecasts are calculated by applying a Kalman filter. T

It has been shown that users of a digital system perceive a more ‘masculine-sounding’ female voice as more persuasive and intelligent than a corresponding but more ‘feminine-sounding’ female voice. Our study explores whether a parallel pattern of affectively colored evaluations can be elicited when femininity and masculinity are manipulated via visual cues instead of via voice. 80 participants enc

The development of tolerant microorganisms is needed for the efficient fermentation of inhibitory lignocellulose hydrolysates. In the current work, the fermentation performance of six selected strains of Saccharomyces cerevisiae in dilute-acid spruce hydrolysate was compared using two different modes of fermentation; either single pulse addition of hydrolysate to exponentially growing cells or con

For the past decade innovativeness, as opposed to innovation, has received considerable attention in the academic literature as well as the corporate arena because it is considered to promote a competitive advantage. This study examines the link between innovativeness and performance of SMEs in the Swiss watch industry, in terms of customer orientation, competition orientation and inter-functional

The first generation of an organic nanotube based on the enantiomerically pure bicyclo[3.3.1]nonane framework is presented. The helical tube synthesised is the longest to date having its aromatic systems oriented parallel to the axis of propagation (length ∼26 Å and inner diameter ∼11 Å according to molecular dynamics simulations in chloroform). The synthesis of the tube, a heptamer, is based on a

This study considered trends in the intergenerational transmission of social assistance (SA) among young adults in Finland, Norway and Sweden during the 2000s. Comparable administrative register data-sets enabled us to compare year by year the social assistance recipiency of 20-year-old adults in the period 1999–2008, together with information on their parents' social assistance recipiency at the

Abstract in Undetermined While women today often face a substantial wage penalty for childbearing, we show that this was not always the case, making use of a rich material of matched employer-employee data covering the Swedish tobacco industry in 1898 in its entirety. Although working conditions were dire, and hours long, women working in the late nineteenth-century manufacturing industry faced noWhile women today often face a substantial wage penalty for childbearing, we show that this was not always the case, making use of a rich material of matched employer-employee data covering the Swedish tobacco industry in 1898 in its entirety. Although working conditions were dire, and hours long, women working in the late nineteenth-century manufacturing industry faced no motherhood penalty. Comp

We present high spatial resolution ion-microprobe U-Th-Pb geochronology and rare earth element (REE) data combined with cathodoluminescence (CL) and back-scattered electron (BSE) imaging for complex zircons in incipient charnockites from Sondrum, SW Sweden. Examination of closely paired samples across the dehydration zone demonstrates that incipient charnockite formation at Sondrum is a zircon-for

The Hieracium flora of die famous botanical site Mt. Taberg (prov. Smaland, S. Sweden) was investigated in 2005. This small but steel) mountain is entirely made up of ultrabasic bedrock and leas a very rich flora. Previous investigations (mainly from die period 1880-1930) leave reported 37 species belonging to H. sect. Hieracium and sect. Vulgata (including the "bifidum - group"), including four e

Essay on the international stereotype of Sweden and how it is reproduced in Henning Mankell's Wallander novels and in the British tv-series starring Kenneth Branagh.

One of the major quantitative trait loci (QTLs) associated with arthritis in crosses between B10.RIII and RIIIS/J mice is the Cia5 on chromosome 3. Early in the congenic mapping process it was clear that the locus was complex, consisting of several subloci with small effects. Therefore, we developed two novel strategies to dissect a QTL: the partial advanced intercross (PAI) strategy, with which w