Aims/hypothesis: The study aimed to investigate the effects of HLA class I genes on susceptibility to type 1 diabetes with different onset ages, in addition to the well-established effects of HLA class II genes. Methods: A total of 361 patients with type 1 diabetes (192 patients with onset

The sources, extent and margins of parental obligations in taking decisions regarding their children’s medical care are subjects of ongoing debates. Balancing children’s immediate welfare with keeping their future open is a delicate task. In this paper, we briefly present two examples of situations in which parents may be confronted with the choice of whether to authorise or demand non-therapeutic

A theoretical and experimental study of the gas phase and liquid acetic acid based on resonant inelastic x-ray scattering (RIXS) spectroscopy is presented. We combine and compare different levels of theory for an isolated molecule for a comprehensive analysis, including electronic and vibrational degrees of freedom. The excitation energy scan over the oxygen K-edge absorption reveals nuclear dynam

Marginalised agrarian societies are suggested to be the most vulnerable to environmental hazards and other perturbations. There are competing explanations for this phenomenon, which include: a lack of development, global environmental change, and the development process itself, or capitalism more specifically. All three causal arguments are compelling, but typically offer only partial explanations

Novel micro-scale reaction devices are progressing in various applications. Whereas, specialized gas-producing reactors of high conversion at micro/mini scale remain challenging and are rarely explored, but are needed urgently in new generation vehicles and aerospace applications. In this work, two kinds of high-aspect-ratio flat channel (200 μm depth, 5.0 mm width, and 40.0 mm length) microreacto

Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes pa

While successes in the prevention of mother-to-child transmission program are believed to lead to substantial reductions in new perinatal infections, new sexually acquired infections among the older adolescent group seem to fuel the HIV epidemic. That is why adolescents are the only age group in which an increase in new HIV infections was reported in the latest global HIV progress update. Increase

This 'Scandia utblick' discusses the continued development of the history of emotions from when the field was introduced in Scandia ten years ago until the present day.

In this work, we study the stationary structures and the breathing mode behavior of a two-dimensional self-bound binary Bose droplet. We employ an analytical approach using a variational ansatz with a super-Gaussian trial order parameter and compare it with the numerical solutions of the extended Gross-Pitaevskii equation. We find that the super-Gaussian is superior to the often used Gaussian ansa

Aim: This study aimed to identify from different stakeholders the benefits and obstacles of implementing precision medicine in diabetic kidney disease (DKD) and to build consensus about a way forward in order to treat, prevent, or even reverse this disease. Methods: As part of an ongoing effort of moving implementation of precision medicine in DKD forward, a two-day consensus-building meeting was

Objective: To evaluate the potential of diffusional variance decomposition (DIVIDE) for grading, molecular feature classification, and microstructural characterization of gliomas. Materials and methods: Participants with suspected gliomas underwent DIVIDE imaging, yielding parameter maps of fractional anisotropy (FA), mean diffusivity (MD), anisotropic mean kurtosis (MKA), isotropic mean kurtosis

This article describes and critically examines the challenging task of compiling The London–Lund Corpus 2 (LLC–2) from start to end, accounting for the methodological decisions made in each stage and highlighting the innovations. LLC–2 is a half-a-million-word corpus of contemporary spoken British English with recordings from 2014 to 2019. Its size and design are the same as those of the world's f

A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on th

Previous studies suggest that the effects of ethanol on carbachol-stimulated I(1,4,5)P3 formation and on the number of mAChRs may be independent of each other. The aim of this work was to further study this hypothesis. Human neuroblastoma SH-SY5Y cells were used as a model system. Acute exposure of the cells to 100 mM ethanol induced a decrease in [3H]N-methylscopolamine ([3H]NMS) binding at 30 se

Different types of well-being are likely to be associated with different kinds of behaviors. The first objective of this study was, from a subjective well-being perspective, to examine whether harmony in life and satisfaction with life are related differently to cooperative behaviors depending on individuals' social value orientation. The second objective was, from a methodological perspective, to