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Skeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in interorgan cross talk. Using mass spectrometry (MS)-based proteomics, we characterized the secretome and identified thymosin b4 (TMSB4X) as the most upregulated secreted protein in the media of contracting C2C12 myotubes. TMSB4X was also acutely increased in the plasma of exercising h
Synthetic three-dimensional (3D) nanoarchitectures are providing more control over light–matter interactions and rapidly progressing photonic-based technology. These applications often utilize the strong synergy between electromagnetic fields and surface plasmons (SPs) in metallic nanostructures. However, many of the SP interactions hosted by complex 3D nanostructures are poorly understood because
Part of the Romantic Europe: The Virtual Exhibition (RÊVE), this text describes Stonehenge as it was portrayed in the eighteenth century.
Objective: The studies of early life factors and development of functional bowel diseases show inconsistent results. We therefore examined associations between certain early life factors and functional bowel symptoms in adulthood. Design: Population-based cross-sectional study. Setting: Weight and height were measured and questionnaires were completed at the time point of enrollment in MOS. Subjec
Aims: Because evidence regarding risk stratification predicting prognosis of patients with heart failure (HF) decompensation attended in primary care is lacking, we developed and externally validated a model to forecast death/hospitalization during the first 30 days after an episode of decompensation. The predictive model is based on variables easily obtained in primary care settings. Methods and
We provide a natural resource explanation for the divergence of the Portuguese economy relative to other European countries before the Second World War. First, we demonstrate that a lack of domestic resources meant that Portugal experienced limited and unbalanced growth during the age of steam. Imports of coal were prohibitively expensive for inland areas. Coastal areas industrialized through stea
It is currently unclear whether plasma biomarkers can be used as independent prognostic tools to predict changes associated with early Alzheimer's disease. In this study, we sought to address this question by assessing whether plasma biomarkers can predict changes in amyloid load, tau accumulation, brain atrophy and cognition in non-demented individuals. To achieve this, plasma amyloid-β 42/40 (Aβ
Background: The COVID-19 pandemic has affected not only somatic health with over 3.7 million deaths worldwide, but also has had a huge impact on psychological health, creating what amounts to a mental health crisis. The negative effect of the pandemic on traditional addictions is well described and concerning, and the same has been seen for gambling. Objective: This study explores self-reported we
BACKGROUND: Corin is a protease expressed in cardiomyocytes that plays a key role in salt handling and intravascular volume homeostasis via activation of natriuretic peptides. It is unknown if Corin loss-of-function (LOF) is causally associated with risk of coronary artery disease (CAD). METHODS: We analyzed all coding CORIN variants in an Italian case-control study of CAD. We functionally tested
BACKGROUND: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality and morbidity. We sought to identify genomic variants associated with PAD overall and in the contexts of diabetes and smoking status. METHODS: We identified genetic variants associated with PAD and then meta-analyzed with published summary statistics from the Million Veterans Pro
Study region: The Kaidu River Basin (KRB) is located on the central southern slope of the Tianshan Mountain in Northwest China. Study focus: This work aimed to assess changes and main drivers of snowmelt-driven runoff in KRB associated with three future climate scenarios. Six versions of the “Cemaneige” snowmelt module embedded in the hydrological model “GR4J” were calibrated and evaluated. The bi
Parents are assumed to play a crucial role in the socioeconomic attainment of children. Through investments of both time and resources, they promote the ability, human capital, networks, and motivation of their children to advance socially, or at least to maintain their social position. Consequently, losing a parent in childhood could be detrimental to adult socioeconomic outcomes. We use full-cou
The security analysis of Keccak, the winner of SHA-3, has attracted considerable interest. Recently, some attention has been paid to the analysis of keyed modes of Keccak sponge function. As a notable example, the most efficient key recovery attacks on Keccak-MAC and Keyak were reported at EUROCRYPT’15 where cube attacks and cube-attack-like cryptanalysis have been applied. In this paper, we devel
The security analysis of Keccak, the winner of SHA-3, has attracted considerable interest. Recently, some attention has been paid to distinguishing Keccak sponge function from random permutation. In EUROCRYPT'17, Huang et al. proposed conditional cube tester to recover the key of Keccak-MAC and Keyak and to construct practical distinguishing attacks on Keccak sponge function up to 7 rounds. In thi
In this paper we study the problem of recovering a secret S-box from its difference distribution table (DDT). While being an interesting theoretical problem on its own, the ability to recover the S-box from the DDT of a secret S-box can be used in cryptanalytic attacks where the attacker can obtain the DDT (e.g., in Bar-On et al.’s attack on GOST), in supporting theoretical analysis of the propert
The vascular effects of endogenous substances can be eas- ily studied in the skin. Early in this century vasoregulation was shown to be dependent on innervation. Peptidergic trans- mitters have been shown to coexist and cotransmit along with noradrenalin and acetylcholine, sometimes being responsi- ble for non-adrenergic-non-cholinergic responses. This review summarizes recent information on vasor
BACKGROUND: The Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Antiplatelet Therapy (PRECISE-DAPT) score has been shown to predict out-of-hospital major bleeding after myocardial infarction treated with percutaneous coronary intervention and dual antiplatelet therapy (DAPT). However, large validation studies have been scarce and the discriminative a
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. The pathophysiological mechanisms leading to low platelet levels in ITP have not been resolved, but at least involve autoantibody-dependent and/or cytotoxic T cell mediated platelet clearance and impaired megakary-opoiesis. In addition, T cell imbalances involving T regulatory cells (Tregs) also appear to play an important role. Int
