Sporulation in Ashbya gossypii is induced by nutrient-limited conditions and leads to the formation of haploid spores. Using RNA-seq, we have determined a gene set induced upon sporulation, which bears considerable overlap with that of Saccharomyces cerevisiae but also contains A. gossypii-specific genes. Addition of cyclic AMP (cAMP) to nutrient-limited media blocks sporulation and represses the Sporulation in Ashbya gossypii is induced by nutrient-limited conditions and leads to the formation of haploid spores. Using RNA-seq, we have determined a gene set induced upon sporulation, which bears considerable overlap with that of Saccharomyces cerevisiae but also contains A. gossypii-specific genes. Addition of cyclic AMP (cAMP) to nutrient-limited media blocks sporulation and represses the

Fungal cells are exposed to rapidly changing environmental conditions, in particular with regard to the osmotic potential. This requires constant remodeling of the cell wall and, therefore, the cell wall integrity (CWI) MAP-kinase pathway plays a major role in shaping the fungal cell wall to protect from adverse external stresses. To provide a comprehensive functional analysis of the Ashbya gossypFungal cells are exposed to rapidly changing environmental conditions, in particular with regard to the osmotic potential. This requires constant remodeling of the cell wall and, therefore, the cell wall integrity (CWI) MAP-kinase pathway plays a major role in shaping the fungal cell wall to protect from adverse external stresses. To provide a comprehensive functional analysis of the Ashbya gossyp

This article discusses the concepts of knowledge-intensive workers and firms. the functional view is questioned and a perspective on knowledge as institutionalized myth and rationality-surrogate is proposed. the ambiguity of knowledge work is emphasized and it is argued that a crucial dimension of a knowledge-intensive organization concerns the struggle with this ambiguity, which leads to efforts

This paper discusses the popularity of postmodernism in social and organizational studies. It is argued that the word conflates quite different social phenomena and lines of development, and theoretical and philosophical positions. Framing issues in terms of modernism/postmodernism easily leads to insensitive conceptualizations of the varied positions within what is dumped together as 'modernism'.

The relay autotuner provides a simple way of finding PID controller parameters. Even though relay autotuning is much investigated in the literature, the practical aspects are not that well-documented. In this paper an asymmetric relay autotuner with features such as a startup procedure and adaptive relay amplitudes is proposed. Parameter choices and handling of noise, disturbances, start in non-st

In the beginning of the public career of Jesus, Mark and Matthew both narrate how Jesus “calls” four fishermen to follow him which results in an immediate positive response (Mark 1:16–20/Matt 4:18–22). How is the reader to understand Jesus’ calling of disciples? Is Jesus making an authoritative command or does he merely invites the fishermen? What is Jesus doing when he “calls” his disciples? ThesIn the beginning of the public career of Jesus, Mark and Matthew both narrate how Jesus “calls” four fishermen to follow him which results in an immediate positive response (Mark 1:16–20/Matt 4:18–22). How is the reader to understand Jesus’ calling of disciples? Is Jesus making an authoritative command or does he merely invites the fishermen? What is Jesus doing when he “calls” his disciples? Thes

We discuss thermal fluid-structure interaction processes, where a simulation of the time-dependent temperature field is of interest. Thereby, we consider partitioned coupling schemes with a Dirichlet-Neumann method. We present an analysis of the method on a model problem of discretized coupled linear heat equations. This shows that for large quotients in the heat conductivities, the convergence ra

The aim of the study was to assess the role of allogeneic stem cell transplantation (SCT) in patients diagnosed with BCR-ABL1-positive acute myeloid leukemia (AML). Fifty-seven patients (median age, 48 years, range: 19-67) with BCR-ABL1 positive AML undergoing SCT were identified. The majority of the patients (70%) received a TKI before the transplant. At SCT 48 patients were in CR (45 in CR1), wh

18F-dopa PET measuring aromatic l-amino acid decarboxylase activity is regarded as the gold standard for evaluating dopaminergic function in Parkinson's disease. Radioligands for dopamine transporters are also used in clinical trials and for confirming PD diagnosis. Currently, it is not clear which imaging marker is more reliable for assessing clinical severity and rate of progression. The objecti

Introduction: Prolonged pregnancies are associated with adverse maternal and fetal outcome. In Sweden, no national guidelines exist for when to induce prolonged pregnancies. Material and methods: Singleton cephalic prolonged pregnancies (defined as ≥ 41+3 gestational weeks) during 2001-2013 (n = 199 770) were identified using the Swedish Medical Birth Register. The maternity units were divided int

Human cystatin C (HCC), a small protein, plays a crucial role in inhibition of cysteine proteases. The most common structural form of human cystatin C in crystals is a dimer, which has been evidenced both for the native protein and its mutants. In these structures, HCC dimers were formed through the mechanism of domain swapping. The structure of the monomeric form of human cystatin C was determine

A new strategy for designing ternary solar cells is reported in this paper. A low-bandgap polymer named PTB7-Th and a high-bandgap polymer named PBDTTS-FTAZ sharing the same bulk ionization potential and interface positive integer charge transfer energy while featuring complementary absorption spectra are selected. They are used to fabricate efficient ternary solar cells, where the hole can be tra

Objectives: The aim of the study was to assess whether bone mass and metabolism are impaired in genetically at-risk children with screening-detected celiac disease. Methods: Included were 71 children with screening-detected celiac disease diagnosed at 10.0 ± 0.7 (mean ± standard deviation) years and 142 matched controls and 30 children with screening-detected celiac disease diagnosed at 3.3 ± 0.4

BACKGROUND AND OBJECTIVES: Few birth cohorts have prospectively followed development of type 1 diabetes (T1D) and celiac disease (CD) autoimmunities to determine timing, extent of co-occurrence, and associated genetic and demographic factors.METHODS: In this prospective birth cohort study, 8676 children at high genetic risk of both diseases were enrolled and 5891 analyzed in median follow-up of 66

Objectives: Among patients who underwent primary surgery for non-small cell lung cancer (NSCLC), recurrent disease is frequent and cannot be accurately predicted solely from TNM stage and histopathological features. The aim of this study was to examine the association of tumor markers in pre-operative serum with recurrent disease. Material and methods: Blood samples were collected prior to lung ca