Glial cell line derived neurotrophic factor (GDNF) has great potential to treat Parkinson's disease (PD). However, constitutive expression of GDNF can over time lead to side effects. Therefore, it would be useful to regulate GDNF expression. Recently, a new gene inducible system using destabilizing domains (DD) from E. coil dihydrofolate reductase (DHFR) has been developed and characterized. The a

Purpose: Eddy current induced velocity offsets are of concern for accuracy in cardiovascular magnetic resonance (CMR) volume flow quantification. However, currently known theoretical aspects of eddy current behavior have not led to effective guidelines for the optimization of flow quantification sequences. This study is aimed at identifying correlations between protocol parameters and the resultin

Six vaccine formulations containing AS02(V) or alum (aluminum phosphate [AlPO4]) adjuvant with pneumococcal proteins, pneumococcal histidine triad D (PhtD), and/or detoxified pneumolysin (dPly), either as a polysaccharide carrier in an 8-valent pneumococcal conjugate vaccine (8PCV) or as free (unconjugated) proteins, were evaluated in adults -65 to 85 years of age. In this phase I observer-blind s

The popliteal artery (PA) is, after aorta, the most common site for aneurysm formation. Why the PA is more susceptible than other peripheral muscular arteries is unknown. We hypothesized that the wall composition, which in turn affects wall properties, as well as the circumferential wall stress (WS) imposed on the arterial wall, might differ compared to other muscular arteries. The aim was to stud

With the rapid progress in the development of new clinical biomarkers there is an unmet need of fast and sensitive multiplex analysis methods for disease specific protein monitoring. Immunoaffinity extraction integrated with matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) analysis offers a route to rapid and sensitive protein analysis and potentially multiplex biomarker an

Sung in Christian liturgies from the earliest period, biblical Odes—a set of songs excerpted from the biblical and apocryphal books—were central to emerging Christian practices and texts, yet their significance as textual witnesses has rarely been studied. Overlooked by text critics and editors, the Odes have largely been omitted from contemporary critical editions of the biblical books, including

Morocco has for twenty years been in what is officially described as a transition to democracy. During the former king Hassan II negotiations with the opposition resulted in two constitutional reforms and a new government in 1998 dominated by the former opposition parties. In the 2000s two important law reforms were made: a new law of personal status in 2004 and a new constitution in 2011. The new

This paper presents an improved synthetic loading method to measure the performance of an interior permanent magnet synchronous machine (IPMSM). A complete analysis of torque-, flux-, and efficiency-maps are done by means of a vector controlled drive implemented with in a field programmable gate array (FPGA). The measurements are compared to results from Finite Element Analysis (FEA). A key featur

An adaptive controller consisting of a real time identifier and a minimum variance regulator is discussed. The identification is done by augmenting the state with the unknown parameters of the process. This usually leads to a non-linear filtering problem. By choosing a model of special structure the problem can, however, be reduced to a linear problem. The control law is derived using stochastic o

The Cellular Neural Network provides an interesting template for non-linear signal processing. It is essentially based on 2nd-order (reaction / diffusion) differential equations. Harrer and Nossek have introduced the discrete-time equivalent that paves the ground for digital implementation. The interconnect requirements seem to have made it impossible to realistically implement this model. More th

Popular Abstract in English The conventional approach to the analysis of structural change is to apply a horizontal perspective on the economy. This means that sectors are studied in isolation. By the integration of two strands of literature on structural change and the role of technology, evolutionary economics and input-output economics, this thesis applies a vertical perspective on the economy This thesis analyses structural changes and the role of technology in the Swedish economy since the 1970s. With the attention directed towards interdependencies between sectors, a vertical perspective is applied on the economy. This contrats to the most often used horizontal perspective, in which individual sectors, such as manufacturing and services, are studied in isolation. With an integration

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