A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27-IgMhigh B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation
The immune system is dysfunctional for years after hematopoietic stem cell transplantation (HSCT). A potential cause is an intrinsic B cell deficiency. In a cohort of pediatric HSCT patients few CD27+ B cells formed after transplantation with the number of CD27+IgMhigh cells more affected than class-switched ones. A previously unacknowledged population of CD27-IgMhigh cells made up the majority of