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Inhibition of the Rho-kinase (ROCK) signalling pathway has widespread effects on cellular behaviour. In the cornea, ROCK inhibitors promote the integrity of the epithelial layer and limbal stem cells and regeneration of the endothelium layer. Clinical studies have demonstrated successful regeneration of the endothelium using ROCK inhibitors without a corneal graft in patients with corneal endothel
Recent developments in Alzheimer's disease biomarkers have significantly improved the early detection of Alzheimer's disease pathology (Hansson et al., 2023; Ossenkoppele and Hansson, 2021; Zetterberg and Blennow, 2021) [1-3]. However, while biomarkers for Alzheimer's disease can indicate the underlying brain pathology and have some predictive value for future cognitive decline, they do not provid
This paper acknowledges the influence of Dr Rita Fahy’s life’s work on a research project to evaluate fire evacuation guidance from high-rise residential buildings. It compares the application of agent-based simulations with Rita’s publications into pre-evacuation delay times. Her observed bi-modal distribution shape aligns with an approach to modelling pre-evacuation time as a series of component
Warfare has been commonly associated with increasing levels of inflation, with important implications for tax systems. In this chapter, we first review the literature on war finance and inflation, considering both the fiscal causes of inflation during wartimes and the effects of inflation on tax revenues. Second, we focus on developments with regard to income tax during the World Wars, building up
Sialoblastoma is an exceedingly rare, low-grade malignancy, most frequently arising in the parotid gland. Only four case reports detailing the cytomorphology of this neoplasm exist in the English literature. Here, we describe the cytological features, histopathology, and clinical data of sialoblastomas presented at birth in two additional patients. Both neoplasms were initially examined by fine-ne
A dislocation-based flow stress model is proposed to describe the behavior of Alloy 718 fabricated using laser-based and electron-beam powder bed fusion methods. This physics-based model is adaptive to microstructural variations including the size and volume fraction of γ″ precipitates, crystallographic texture, grain size and the density of immobile dislocations. Coupled with data from thermodyna
Autonomous vehicles (AVs) have been the subject of extensive research in recent years and are expected to completely transform the operation of transport networks and revolutionize the automotive industry in the coming decades. Modeling detailed interactions among vehicles with varying levels of penetration rates is essential for evaluating the potential effects. One such investigation is being pe
Orbit separation dimension , previously introduced as amorphic complexity, is a powerful complexity measure for topological dynamical systems with pure-point spectrum. Here, we develop methods and tools for it that allow a systematic application to translation dynamical systems of tiling spaces that are generated by primitive inflation rules. These systems share many nice properties that permit th
Quasi-markets are increasingly used in public service provision, yet they remain highly contested. This paper develops a conceptual framework grounded in economic theory to examine how quasi-markets differ from traditional markets along five key dimensions: (1) revenues, costs, and profits, (2) the matching of supply and demand, (3) competition, (4) structural change, and (5) rent-seeking. Assumin
Long-term noninvasive respiratory support, comprising continuous positive airway pressure (CPAP) and noninvasive ventilation (NIV), in children is expanding worldwide, with increasing complexities of children being considered for this type of ventilator support and expanding indications such as palliative care. There have been improvements in equipment and interfaces. Despite growing experience, t
This report presents findings from the case study on food sharing in the city of Milan, Italy, which was performed as part of the project CULTIVATE: Co-designing Food Sharing Innovation for Resilience: https://cultivate-project.eu/ in June 2024 - November 2024. The study aims to understand the economic, social, and environmental aspects of FSIs, which include growing and composting together, cooki
Pregnant women have historically and are currently being excluded from cervical cancer screening in most low and middle-income countries (LMICs). The aim of this study was to assess the feasibility and outcomes of including pregnant women in a HPV self-sampling-based screening program in Ethiopia. Pregnant women, recruited from a previously established cohort, were included. They answered a questi
When language learning takes place post-migration, the challenge is not only to attain fluency. Learning is tied up with life opportunities and is overshadowed by hopes and fears for the future. In the post-migration phase, hopeful thinking can support the acculturation process. Hope is a goal-related construct that captures variation in adaptability in the pursuit of positive outcomes. It involve
Our research aims to develop an intelligent control system for optimizing the operation of lighting systems for a jogging track in the countryside by using adaptive control methods, and optimization of built-in lighting control. Through this, lighting systems will be optimized, energy consumption will be minimized and the lighting system will be adapted to be able to handle a larger amount of loca
