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Candida albicans is a major cause of invasive fungal infections worldwide. Upon infection and when in contact with human plasma as well as body fluids the fungus is challenged by the activated complement system a central part of the human innate immune response. C. albicans controls and evades host complement attack by binding several human complement regulators like Factor H, Factor H-like protei

The aim of this study was to develop (68)Ga-SPIONs for use as a single contrast agent for dynamic, quantitative and high resolution PET/MR imaging of Sentinel Lymph Node (SLN). In addition (68)Ga enables Cherenkov light emission which can be used for optical guidance during resection of SLN. SPIONs were labeled with (68)Ga in ammonium acetate buffer, pH 5.5. The labeling yield and stability in hum

Kanon och kulturarv har diskuterats intensivt de senaste åren i Danmark och Sverige. I Danmark har regeringens beslut att definiera en dansk kanon väckt stor debatt. I Sverige har diskussionen varit hovsammare samtidigt som ordet kulturarv har ett starkt grepp om museer, kulturmiljövård och arkiv. I Danmark har diskussionen kretsat kring vad som är danskt, vem som ska definiera danskheten och vil

Background. Studies suggest an increased risk for compromised cognitive function among cancer survivors. It is unclear to what extent chemotherapy is the cause and how the dysfunction, when present, affects everyday life. The objective was to study self-reported behaviours that may depend on cognitive function, among testicular-cancer survivors who received various cycles of cisplatin-based chemot

While the conceptual history of the sign, as recounted by John Deely in Four ages of understanding, is immensely enlightening, history is never enough. If, before Augustine, it had occurred to no one that such diverse phenomena as are covered by this term had something in common, and if, in the time of Aquinas, Fonseca, and Poinsot, different usages of the term were in competition, the reason is n

In high energy collisions saturation and multiple collisions are most easily accounted for in transverse coordinate space, while analyses in momentum space have been more suitable for calculating properties of exclusive final states. In this paper I describe an extension of Mueller's dipole cascade model, which attempts to combine the good features of both these descriptions. Besides saturation it

The flow fields and heat transfer characteristics in a parallel-plate channel with a transversely placed spiral coil insert were investigated by three-dimensional numerical simulation. The structure of multi-longitudinal-vortices (MLVs) induced by the spiral coil and the effects of MLVs on velocity and temperature fields were studied. The three-dimensional spiral coil induces a series of longitudi

Background: Few studies have compared self-reported criminal behaviour with high-quality databases of criminal offences and judicial sanctions. Self-reported problems from drug abusers are generally believed to be valid. We assessed the validity of self-reported theft, drug offences and prison sentences from a five-year follow-up of female substance abusers who were originally treated in a compuls

Previous experimental studies have shown that vitamin C has several beneficial effects in sepsis and burns, such as decreased tissue oedema, improved endothelial barrier function and decreased transcapillary leakage of plasma markers. It has still not been investigated, though, if vitamin C has any impact specifically on plasma volume. The present study aims at testing the hypothesis that vitamin

A label free biosensor for direct detection of inorganic phosphate based on potential-step capacitance measurements has been developed. The high-affinity Pho84 plasma membrane phosphate/proton symporter of Saccharomyces cerevisiae was used as a sensing element. Heterologously expressed and purified Pho84 protein was immobilized on a self-assembled monolayer (SAM) on a capacitance electrode. Change

The male: female (sex) ratio is of considerable importance in understanding population dynamics of species. A null hypothesis was tested that the male:female (sex) ratio of Carabus species does not differ measurably when entire seasons are considered, but may differ considerably over shorter periods, indicating differences in annual rhythms between the sexes. The sex ratios in nine Carabus species

Vad är en fabrik? Med industrisamhällets avveckling följer en ny ruinromantik. Över hela Västvärlden blir slitna tegelfasader och rostbruna maskinhallar till nya utflyktsmål, gallerier, caféer eller trendiga arbetsplatser. Samtidigt skapas nya industrilokaler, där besökarnas intryck är lika viktiga som den tillrättalagda produktionen. Är det bilar eller upplevelser som tillverkas här? Industrial

Popular Abstract in Swedish Titelns första del är ett Walter Benjamin-citat som bildar utgångspunkt och förklaras i avhandlingens första kapitel. Tidigare forskning, samlat till fyra tematiska områden, presenteras: drottning Kristina själv och hennes lärdom, bibliotekarierna och de andra lärda, det kungliga biblioteket i Stockholm och samlingen i Rom. Bibliotekets tidiga historia, hur det kommer tThis study examines how the Latin manuscript collection of Queen Christina of Sweden was formed, what function it served for the queen and for others, and how various attempts to impose order on it reflect different epistemological traditions. A recurring theme of the study is the creation of order and the title, The Mild Boredom of Order, a quotation taken from an essay on book collecting by Walt

A brief historical background to the currently ascend- ing interest in evolutionary and coevolutionary theory is sketched, and the concept of society–nature coevolution is positioned in this broader field. The significance of society–nature coevolution- ary pathways for transition to sustainability is highlighted with Schellnhuber’s heuristic ‘theater world’ for representing paradigms of sustainab

A genome-wide association study (GWAS) performed on a high-incidence Italian population followed by replications on low-incidence cohorts suggested a strong association of differentiated thyroid cancer (DTC) with single nucleotide polymorphisms (SNPs) at 9q22.33, 2q35, 20q11.22-q12 and 14q24.3. Moreover, six additional susceptibility loci were associated with the disease only among Italians. The p

Background Overexpression of human epidermal growth factor receptor 2 (HER2) or amplification of its gene is a prognostic factor in primary breast cancer and a predictor for tamoxifen treatment efficacy in oestrogen receptor (ER) positive disease. In the present study we explored a defined cohort of breast cancer patients included in a randomised trial in order to assess prognostic and tamoxifen t