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Inheriting “Difficult Histories” : National Identities, Memory Debates and Cultural Diversity
For some reason, modern European nations have traditionally presented themselves as having a lot of rich and important history, much of it portrayed as being “international” in terms of cultural impact and wider global significance. Today, much of this history appears to be far more controversial than many comfortable national-popular narratives have acknowledged. This article explores how Europe
Living Dangerously : Archaeological Insights Into Jomon Engagement With Volcanic Geohazards In Prehistoric Japan
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Early fate decisions in hematopoietic stem and progenitor cells. Through the lens of genomic and functional assays.
Hematopoietic stem cells (HSCs) are rare cells on top of the differentiation hierarchy of hematopoiesis. HSCs are unique in their combined capacity to differentiate into all mature blood lineages and self-renew to maintain the HSC pool. Based on classical models of hematopoiesis in mouse, the self-renewal potential of HSCs is gradually and step-wise lost during the transition from long term (LT)-H
Gunnar Broberg in memoriam
Gunnar Broberg, professor emeritus i idé- och lärdomshistoria vid Lunds universitet, gick ur tiden lördagen den 30 april 2022 i en ålder av 79 år.
Duplex Sequencing Uncovers Recurrent Low-frequency Cancer-associated Mutations in Infant and Childhood KMT2A-rearranged Acute Leukemia
Infant acute lymphoblastic leukemia (ALL) with KMT2A-gene rearrangements (KMT2A-r) have few mutations and a poor prognosis. To uncover mutations that are below the detection of standard next-generation sequencing (NGS), a combination of targeted duplex sequencing and NGS was applied on 20 infants and 7 children with KMT2A-r ALL, 5 longitudinal and 6 paired relapse samples. Of identified nonsynonym
Lung adenocarcinoma promotion by air pollutants
A complete understanding of how exposure to environmental substances promotes cancer formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-step process: an initiating step that induces mutations in healthy cells, followed by a promoter step that triggers cancer development1. Here we propose that environmental particulate matter measuring ≤2.5 μm (PM2.5), known
Mörkret i människan
En mineraliesamling i stenriket
Biological variation of human aggrecan ARGS neoepitope in synovial fluid and serum in early-stage knee osteoarthritis and after knee injury
OBJECTIVE: To determine biological variation of the aggrecanase-generated aggrecan ARGS neoepitope in serum (sARGS) and synovial fluid (sfARGS) within and between patients with osteoarthritis (OA) or anterior cruciate ligament (ACL) injury.DESIGN: Matched samples of serum and synovial fluid were available, as parts of clinical trials, from i) 16 subjects with early-stage OA on 8 occasions over 1 y
Technical performance of a proximity extension assay inflammation biomarker panel with synovial fluid
The plasma proteome can provide a deeper understanding of the pathophysiology of different diseases and is a key source for detection of new biomarkers. Proximity extension assay (PEA), developed by Olink Proteomics (Uppsala, Sweden), detects proteins by using pairs of antibodies that are linked to oligonucleotides; upon target binding, the probes anneal when in proximity and the oligonucleotides
Analysis of Rates of Completion, Delays, and Participant Recruitment in Randomized Clinical Trials in Surgery
IMPORTANCE: Discontinuation and nonpublication are established sources of avoidable waste among surgical trials, but rates of delayed completion and recruiting shortfalls remain unclear.OBJECTIVES: To examine the rate of delayed completion, incomplete enrollment, and discontinuation among randomized clinical trials in surgical populations and the duration of delays and extent of recruiting shortfa
South Africa and the Surgical Diaspora-A Hub for Surgical Migration and Training
BACKGROUND: The shortage of trained surgeons, anesthesiologists, and obstetricians is a major contributor to the unmet need for surgical care in low- and middle-income countries, and the shortage is aggravated by migration to higher-income countries.METHODS: We performed a cross-sectional observational study, combining individual-level data of 43,621 physicians from the Health Professions Council
Modelling why 70 per cent of the world's population lack access to surgery
Public Access to Surgical Care. Studies on Timeliness, Capacity, Safety and Affordability.
Background. A once commonly held belief was that surgery is too complicated, too expensive, and too ineffectively addressing a too minor proportion of the burden of disease to deserve priority in a setting of scarce healthcare resources in low- and middle-income countries. Yet, essential surgical care can be as highly cost-effective as other common public health interventions, and surgical service
TECHNICAL ANALYSIS TO INFORM THE TRIGGER DESIGN FOR ADAPTIVE SAFETY NETS IN MALAWI 2023
Technical Analysis to Inform the Trigger Design for Adaptive Safety Nets in Malawi 2023 has been prepared by the Finance, Competitiveness & Innovation Global Practice’s Crisis, and Disaster Risk Finance team in collaboration with Tetra Tech, who acted as technical advisors for the World Bank. Funding and expertise were provided by the Disaster Protection Program (funded by the UK) and from the
Phytoglobins: Elucidation of Structural, Functional and Practical Features of Non-Symbiotic Plant Hemoglobins
Phytoglobins (Pgb) (plant hemoglobins) are heme-containing proteins and less well known in comparison to the mammalian counterparts hemoglobin (Hb) andmyoglobin (Mb). They share the same secondary structure as other globin-related proteins, six to eight α-helices comprising the myoglobin-fold (Mb-fold) with one prosthetic heme moiety per subunit. Pgbs are divided into different classes, where the Phytoglobins (Pgb) (plant hemoglobins) are heme-containing proteins and less well known in comparison to the mammalian counterparts hemoglobin (Hb) andmyoglobin (Mb). They share the same secondary structure as other globin-related proteins, six to eight α-helices comprising the myoglobin-fold (Mb-fold) with one prosthetic heme moiety per subunit. Pgbs are divided into different classes, where the