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Identifying mobility segments for leisure travel : A cluster analysis based on a one-month travel survey

Despite awareness of the negative consequences of car use, leisure trips are still often made by car. A better understanding of the potential for a transition to more sustainable transport behaviour requires more knowledge about the differences in car use between individuals and leisure trip purposes. As a basis for this, individuals were clustered into six car-oriented and five non-car-oriented l

Experimental Analysis of Physical Interacting Objects of a Building at mmWave Frequencies

Understanding the evolution of multipath components (MPCs) in real radio channels is crucial to enhancing channel modeling and multipath-assisted positioning. This paper provides an experimental analysis of the behavior of MPCs originating from a standard building facade at millimeter wave (mmWave) frequencies. Utilizing a high-resolution channel parameter estimation method alongside a joint clust

Analysis of genetic variant associated with heart failure mortality implicates thymic stromal lymphopoietin as mediator of strain-induced myocardial fibroblast-mast cell crosstalk and fibrosis

Heart failure (HF) is a leading cause of death and disability globally. Heritable factors and the extent and pattern of myocardial fibrosis are important determinants of outcomes in patients with HF. In a genome-wide association study of mortality in HF, we recently identified a genetic polymorphism on chromosome 5q22 associated with HF mortality. Here, we sought to study the mechanisms by which t

A new mass and radius determination of the ultra-short period planet K2-106b and the fluffy planet K2-106c

Ultra-short period planets (USPs) have orbital periods of less than 1 d. Since their masses and radii can be determined to a higher precision than long-period planets, they are the preferred targets to determine the density of planets which constrains their composition. The K2-106 system is particularly interesting because it contains two planets of nearly identical masses. One is a high-density U

A PBPK model for PRRT with [177Lu]Lu-DOTA-TATE : Comparison of model implementations in SAAM II and MATLAB/SimBiology

Physiologically based pharmacokinetic (PBPK) models offer the ability to simulate and predict the biodistribution of radiopharmaceuticals and have the potential to enable individualised treatment planning in molecular radiotherapy. The objective of this study was to develop and implement a whole-body compartmental PBPK model for peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-TATE

Basin-Scale Daily Drought Prediction Using Convolutional Neural Networks in Fenhe River Basin, China

Drought is a natural disaster that occurs globally and can damage the environment, disrupt agricultural production and cause large economic losses. The accurate prediction of drought can effectively reduce the impacts of droughts. Deep learning methods have shown promise in drought prediction, with convolutional neural networks (CNNs) being particularly effective in handling spatial information. I

Outlining recent updates on influenza therapeutics and vaccines : A comprehensive review

Influenza virus has presented a considerable healthcare challenge during the past years, particularly in vulnerable groups with compromised immune systems. Therapeutics and vaccination have always been in research annals since the spread of influenza. Efforts have been going on to develop an antiviral therapeutic approach that could assist in better disease management and reduce the overall diseas

Peptidyl-tRNA hydrolase is the nascent chain release factor in bacterial ribosome-associated quality control

Rescuing stalled ribosomes often involves their splitting into subunits. In many bacteria, the resultant large subunits bearing peptidyl-tRNAs are processed by the ribosome-associated quality control (RQC) apparatus that extends the C termini of the incomplete nascent polypeptides with polyalanine tails to facilitate their degradation. Although the tailing mechanism is well established, it is uncl

Hydrodynamic instabilities in a two-dimensional sheet of microswimmers embedded in a three-dimensional fluid

A collection of microswimmers immersed in an incompressible fluid is characterised by strong interactions due to the long-range nature of the hydrodynamic fields generated by individual organisms. As a result, suspensions of rear-actuated 'pusher' swimmers such as bacteria exhibit a collective motion state often referred to as 'bacterial turbulence', characterised by large-scale chaotic flows. The

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

BACKGROUND: Neutrophils and their inflammatory mediators are key pathogenic components in multiple autoimmune diseases, while their role in human type 1 diabetes (T1D), a disease that progresses sequentially through identifiable stages prior to the clinical onset, is not well understood. We previously reported that the number of circulating neutrophils is reduced in patients with T1D and in presym

Elucidating fungal decomposition of organic matter at sub-micrometer spatial scales using optical photothermal infrared (O-PTIR) microspectroscopy

In microbiological studies, a common goal is to link environmental factors to microbial activities. Both environmental factors and microbial activities are typically derived from bulk samples. It is becoming increasingly clear that such bulk environmental parameters poorly represent the microscale environments microorganisms experience. Using infrared (IR) microspectroscopy, the spatial distributi

Surface sliding revealed by operando monitoring of high-pressure torsion by acoustic emission

High-pressure torsion (HPT) is widely used as a key method for microstructure control through deformation processing across a broad range of materials. However, certain gaps in process control impact its efficacy. In this study, we investigate the acoustic emission (AE) signals generated during HPT by considering commercially pure molybdenum as an example. By employing the adaptive sequential k-me