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Hyperinsulinemia is an adaptive mechanism that enables the maintenance of normoglycemia in the presence of insulin resistance. We assessed whether glucagon is also involved in the adaptation to insulin resistance. A total of 1,437 individuals underwent an oral glucose tolerance test with measurements of circulating glucose, insulin, and glucagon concentrations at 0, 30 and 120 min. Early glucagon

This paper presents a model that uses only pH, alkalinity, and temperature to estimate the concentrations of major ions in rivers (Na+, K+, Mg2+, Ca2+, HCO3 -, SO4 2-, Cl-, and NO3 -) together with the equilibrium concentrations of minor ions and heavy metals (Fe3+, Mn2+, Cd2+, Cu2+, Al3+, Pb2+, and Zn2+). Mining operations have been increasing, which has led to changes in the pollution loads to r

In economic and management literature, the relationship between supplier and buyer can be more or less intimate. It can vary from market-driven with a constant change of suppliers to a value-driven relationship with one sole supplier. Purchasing strategies of construction companies have often been described as short-sighted, where price is the most considered aspect. Recent lean management literat

As part of a long-term project investigating the relevance of phenomenology for (cognitive) linguistics we analyse two central, interrelated concepts: embodied intersubjectivity (intercorporeality) and sedimentation. With respect to the first, we spell out a number of different intercorporeal structures, emanating at the most fundamental level from the dual Leibkörper nature of the body. Further,

The effect molecular crowding, defined as the volume exclusion exerted by one soluble inert molecule upon another soluble molecule, has on the structure and self-interaction of lipid-free apoA-I were explored. The influence of molecular crowding on lipid-free apoA-I oligomerization and internal dynamics has been analyzed using electron paramagnetic resonance (EPR) spectroscopy measurements of nitr

Type 2 diabetes and skeletal muscle insulin resistance have been linked to accumulation of the intramyocellular lipid-intermediate diacylglycerol (DAG). However, recent animal and human studies have questioned such an association. Given that DAG appears in different stereoisomers and has different reactivity in vitro, we investigated whether the described function of DAGs as mediators of lipid-ind

Genome-wide association studies (GWAS) have found few common variants that influence fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated assessment of fasting and dynamic measures of insulin sensitivity would detect novel common variants. We performed a GWAS of the modified Stumvoll Insulin Sensitivity Index (ISI) within the Meta-Analyses of Glucose and Insulin-Re

The term ‘storytelling’ has a long history of prominence in descriptive and prescriptive talk about jazz improvisation. The main aim of this article is to point out that the ways in which jazz musicians themselves employ the ‘storytelling’ metaphor with reference to jazz improvisation display several important perspectives on perennial and fundamental prob- lems in the field of musical narrativity

The etiology of leukemias cannot entirely be explained by known risk factors, including ionizing radiation, benzene exposure, and infection with human T cell leukemia virus. A number of studies suggested that diet influences the risk of adult leukemias. However, results have been largely inconsistent. We examined the potential association between dietary factors and risk of leukemias among partici

Introduction Left frontal brain lesions are known to give rise to aphasia and impaired word associations. These associations have previously been difficult to analyze. We used a semantic space method to investigate associations to cue words. The degree of abstractness of the generated words and semantic similarity to the cue words were measured. Method Three subjects diagnosed with Broca’s aphasia

We describe a simple method to detect significant changes of the total ozone column from global (diffuse and direct) zenith sky measurements taken at the Earth’s surface. The calculation of the total ozone column relies on measured irradiance at two wavelengths in the ultra violet part of the solar spectrum. One of these (i.e. 306 nm) are appreciable absorbed by ozone whereas the other (i.e. 360 n

OBJECTIVE: People with disabilities find it harder to enter the labour market than people without disabilities and those with a mental illness are, in relation to people with other disabilities, employed at an essentially lower extent. Many are effectively helped by the vocational rehabilitation model Individual Placement and Support (IPS), but there are still many individuals left in undesired un

Peptides derived from apolipoprotein B (apoB)-100 have been previously used in vaccine preparations to treat atherosclerosis. Such vaccines have been shown to reduce atherosclerotic plaque development by 50 % in experimental animals, and this effect is associated with induction of T helper (Th)2 immune responses. In this study we immunised apolipoprotein E-deficient (apoE(-/-)) mice with apoB-100-

The aim was to assess long-term cognitive performance after substantial recovery from work-stress-related exhaustion, in relation to subjective cognitive complaints and return to active work. In total, 54 patients previously diagnosed with work-stress-related exhaustion participated in a neuropsychological examination similar to 2 years after initial sick leave. Most participants were substantiall

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identifi