Combinations of genetic and environmental factors contribute to the pathogenesis of type 2 diabetes (T2D); however, our knowledge of the molecular mechanisms by which these factors trigger diabetes is still limited. While genome-wide association studies have identified and characterized more than 60 genomic loci associated with T2D, recent methylome charts and reference regulatory maps obtained fr

The thesis discusses the licensing system of the Creative Commons from the perspective of the theory of the commons mostly as formulated by Elinor Ostrom. The work starts by describing the concepts and theory of common pool resources and regime of the commons for production and distribution of these resources. The main characteristics for successful traditional commons – efficiency, equity and sus

The associations of body mass index (BMI) and other anthropometric measurements with lung cancer were examined in 348,108 participants in the European Investigation Into Cancer and Nutrition (EPIC) between 1992 and 2010. The study population included 2,400 case patients with incident lung cancer, and the average length of follow-up was 11 years. Hazard ratios were calculated using Cox proportional

Background: The contribution of kinesiophobia (fear of movement) to the pain experience among older adults has been poorly evaluated. The aim of this study was to study prevalence at baseline, development over a 12-month period and cognitive-affective variables of kinesiophobia in a population-based sample of older adults with chronic pain. Methods: The study included 433 older adults (+65 years)

According to Silvan Tomkins’ (1963, 1965) Polarity Theory, all ideologies are polarized by a fundamental conflict between Humanism, which idealizes and glorifies humanity, and Normativism, which portrays human beings as inherently worthless and able to attain value only through achievement of external norms. Research has shown that Humanism and Normativism do indeed form two coherent and negativel

In this paper I draw on two case studies of how environmental impacts are assessed in large scale golf developments to illustrate the political ecology of leisure and how countrysides are reshaped to cater for elite consumption (McCarthy 2008). In 2008 Trump International Golf Links Scotland gained permission to build a golf resort, potentially the largest in the UK, along the Aberdeenshire coast.

The legislated goals for Master of Science in Engineering educations include goals like having the ability to critically, independently and creatively identify, formulate and handle complex problems as well as participate in research and development work and thus contribute to knowledge development. One might therefore argue that these educations are required to promote a deep approach to learning

Stylistic Fronting (SF) is a process that fronts various types of non-subjects to the preverbal position in subjectless clauses (“that gone have”, etc.). With the exception of Icelandic and to some extent Faroese, SF has disappeared from Scandinavian varieties. It is commonly assumed that even in Icelandic it is formal and old fashioned, indicating that it might be on its way out of this language

Caveolae are membrane invaginations present at high densities in muscle and fat. Recent work has demonstrated that myocardin family coactivators (MYOCD, MKL1), which are important for contractile differentiation and cell motility, increase caveolin (CAV1, CAV2, CAV3) and cavin (CAVIN1, CAVIN2, CAVIN3) transcription, but several aspects of this control mechanism remain to be investigated. Here, usi

In an earlier study, infection of human pancreatic islets with epidemic strains of echovirus (E4, E16, E30), with proven but differently ability to induce islet autoimmunity, resulted either in a severe damage (i.e. E16 and E30) or proceeded without visible changes in infected islets (i.e. E4). In this study, the ability of these strains to replicate in beta cells and the consequence of such an in