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We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple n

The Vel antigen is present on red blood cells (RBCs) from all humans except rare Vel-negative individuals who can form antibodies to Vel in response to transfusion or pregnancy. These antibodies may cause severe hemolytic reactions in blood recipients. We combined SNP profiling and transcriptional network modeling to link the Vel-negative phenotype to SMIM1, located in a 97-kb haplotype block on c

Background The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. Methods 2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. Results NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG with

A plethora of candidate genes have been identified for complex polygenic disorders, but the underlying disease mechanisms remain largely unknown. We explored the pathophysiology of type 2 diabetes (T2D) by analyzing global gene expression in human pancreatic islets. A group of coexpressed genes (module), enriched for interleukin-1-related genes, was associated with T2D and reduced insulin secretio

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated wi

A three-phase hollow fiber liquid phase microextraction (HF-LPME) method was evaluated for the extraction and preconcentration of naproxen and diclofenac using a polypropylene membrane followed by analysis using HPLC or LC/MS. In this technique, the drugs were extracted into di-n-hexyl ether immobilized in the wall pores of a porous hollow fiber from 50mL of sludge slurry sample as a donor phase w

Today, with many of the technological issues of integrated information management resolved (perhaps excluding the matter of interoperability), defining the content and status of BIM information deliveries remains both a practical and a theoretical problem. New BIM tools and new design processes and procedures have led to a certain confusion of what information is needed for particular BIM uses. Th

Popular Abstract in English Knowledge can be many things; it can be metaphysical, enhancing the understanding of human beings and social relations. It can be hard facts, information, structure and ordering of nature. Knowledge can be inherent in the knowing subject – the emancipated subject, or it can exist as an entity independent of its founder. An apposite metaphor is knowledge as an end in its

The pancreatic islet beta-cells are the target for an autoimmune process that eventually results in an inability to control blood glucose due to the lack of insulin. The different steps that eventually lead to the complete loss of the beta-cells are reviewed to include the very first step of a triggering event that initiates the development of beta-cell autoimmunity to the last step of appearance

The role of quantitative risk analysis as a foundation for decision making, regarding hazardous activities and establishments, has gained increased importance during the last decades. When performing a quantitative risk analysis, a wide range of uncertainties will inevitably be introduced during the process. The impact of these uncertainties must somehow be addressed if the analysis is to serve as

Departing from the renewed interest within economic history and neo-Schumpeterian perspectives on growth and economic transformation, we will suggest a theoretical framework for analyzing long term regional economic growth and transformation. Emphasis will be given to different driving forces and their various roles over time, lead-lag relations between industries and how divergence and convergenc

This report describes a language and an interactive environment, called LICS, for implementation of control systems and dynamic modelling. It used graphics for representation of the structural properties: hierarchical decomposition, interconnection structure, and structure of the interfaces. The decomposition and interconnection structures are described by block diagrams. Low level modules are des