Sökresultat

Developing systems to identify the cell type-specific functions regulated by genes linked to type 2 diabetes (T2D) risk could transform our understanding of the genetic basis of this disease. However, in vivo systems for efficiently discovering T2D risk gene functions relevant to human cells are currently lacking. Here we describe powerful interdisciplinary approaches combining Drosophila genetics

High trust is a success factor for both societies and organizations. Policy decisions and public administration strategies during the corona pandemic raise a number of questions with regard to trust. To what degree have different decisions and pro-cesses been trust-based and how have these decisions affected outcomes? These questions are difficult to respond to, in particular since trust can emerg

A large proportion of apartment buildings in Europe were built between 1950 and 1990 and many of them are today in need of renovation due to inherently poor quality of design, a lack of subsequent maintenance and the present-day imperative of energy-efficiency. The limited extent of renovation compared with new-build projects suggests that developers find renovation unattractive. The purpose of th

De första levande organismerna uppstod på jorden när den funnits i 1,5 miljarder år. Under de följande tre miljarder åren bildades livet på jorden, och existerade i harmoni, med gravitation, kosmisk-strålning, elektriska och magnetiska fält och dess cyklisk-hemlighetsfulla variationer medan exponeringen från den naturlga mikrovågstrålningen var endast i storleksordningen 210-15 W/kg. Det var i de

The Covid Symptom Study, a smartphone-based surveillance study on COVID-19 symptoms in the population, is an exemplar of big data citizen science. As of May 23rd, 2021, over 5 million participants have collectively logged over 360 million self-assessment reports since its introduction in March 2020. The success of the Covid Symptom Study creates significant technical challenges around effective da

This paper discusses the medieval castle and town Sölvesborg in Blekinge. It was a typical motte and bailey castle consisting of a huge brick tower built on an artificial mound surrounded by an inner moat and a large outer bailey. The castle, which was partly excavated in the 1940’s, 1970’s and in the 2010’s, functioned as the royal Danish castle that controlled Blekinge in the Middle Ages. It has

Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study to identify biomarkers predictive of T1D development. Untargeted proteomics of 2,252 samples from 184 individuals identify 376 re

The success and the costs of infrastructure projects depends to a large extent on a reliable characterisation of the subsurface. Information about the groundwater is crucial to protect groundwater resources and to avoid stability problems. Usually, drillings followed by hydraulic tests are conducted which are reliable but expensive and only give punctual information. The use of the geophysical met

Resection of advanced rectal cancer might result in significant tissue loss, including pelvic floor and parts of the vaginal wall. Pelvic floor reconstruction using a musculocutaneous flap offers optimized healing abilities and the possibility of vaginal reconstruction. In Skåne University Hospital, two different flap techniques are used to reconstruct the perineum: the vertical rectus abdominis m

The PNPLA3 I148M variant is the major genetic risk factor for all stages of fatty liver disease, but the underlying pathophysiology remains unclear. We studied the effect of this variant on hepatic metabolism in homozygous carriers and non-carriers under multiple physiological conditions with state-of-the-art stable isotope techniques. After an overnight fast, carriers had higher plasma β-hydroxyb

Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover mechanisms and candidate biomarkers of diabetic kidney disease (DKD) in Type 1 diabetes (T1D) with replication in Type 1 and 2 diabetes. Sequencing reproducibly s

Evaluating the subground properties during the initial stage of a construction of building is important in order to estimate the suitability of soil quality to the technical requirements of bearing capacity, resistance to stress, and strength. This study presented the evaluation of the geotechnical properties of soil intended for the construction of Max IV facility of Lund University, performed in

Context: Large epidemiological studies often collect non-fasting samples, although the reliability of biomarkers may be uncertain. Objective: To explore the reliability and reproducibility of a single measurement of selected biomarkers in a sub-sample of the Malmö Diet and Cancer cohort. Methods: We estimated single- and average-measures intraclass correlation coefficients (ICC) for oxidized (ox)-