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Adipocyte dysfunction is a crucial driver of insulin resistance and type 2 diabetes. We identified EH domain-containing protein 2 (EHD2) as one of the most highly upregulated genes at the early stage of adipose tissue expansion. EHD2 is a dynamin-related ATPase influencing several cellular processes, including membrane recycling, caveolae dynamics and lipid metabolism. Here, we investigated the ro
Cyclin dependent-kinase 2 (CDK2) plays important functions during the mitotic cell cycle and also facilitates several key events during germ cell development. The majority of CDK2's known meiotic functions occur during prophase of the first meiotic division. Here, CDK2 is involved in the regulation of meiotic transcription, the pairing of homologous chromosomes, and the maturation of meiotic cross
The aim of this presentation is to examine the complex reception history of Astrid Lindgren's classic children's book “Pippi Longstocking” in the GDR based on the appearance and paper quality of the various editions. “Pippi Longstockning” was published in two different editions in 1975 and 1988 by the East Berlin Children's Book Publishing House (Kinderbuchverlag Berlin). The differences between t
The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate suc
Migratory routes and remote wintering quarters in birds are often species and even population specific. It has been known for decades that songbirds mainly migrate solitarily, and that the migration direction is genetically controlled. Yet, the underlying genetic mechanisms remain unknown. To investigate the genetic basis of migration direction, we track genotyped willow warblers Phylloscopus troc
In a prospective population-based study, all open hand, wrist, and forearm injuries that were treated during a 10-year period, at hospitals and emergency wards in three Norwegian cities with 225,000 inhabitants, were registered. Injury severity was graded using the abbreviated injury scale (AIS). For moderate injuries (AIS 2) overall incidence (95% CI) was 59 (56-62), incidence among males 92 (86-
Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136
Psykisk ohälsa ökar i dagens samhälle och användandet av digitala medier likaså. Få studier har gjorts på hur organisationer kommunicerar kring psykisk ohälsa online. 1177.se, Sveriges samlingsplats på nätet för information och tjänster inom hälsa och vård, har skapat en temasida om psykisk hälsa med anledning att sprida kunskap och förändra attityder kring ämnet. Denna studie ämnar att öka förstå
Title: ‘Mobile Commerce App Adoption: Consumer Behavior Differences between Europe and Asia’ Research Question: 1. What are the differences between European and Asian consumer behavior of adopting m-commerce apps? 2. Why is there a different level of m-commerce app adoption between European and Asian consumers? Research Purpose: The purpose of this research is to investigate the reasons why consum
This thesis aims to explore social work practices in relation to sex work. It addresses the research question of what challenges, trends and implications evolve for professional social work in Germany once effective practices in response to prostitution have been identified. These issues are explored through the method of qualitative interviews. The study uses social stigma theory as a theoretica
Bedrägeri är ett brott vars förekomst har ökat stadigt under de senaste åren. Reaktionen från lagstiftarens håll har resulterat i nya brottsrubriceringar och utredningar om huruvida ännu fler borde införas. Syftet med uppsatsen är att kartlägga den reglering av bedrägeribrottslighet som på senare år utökats med nya brottskonstruktioner både inom den allmänna straffrätten och specialstraffrätten. Fraud is a crime that has become more and more frequent lately and the reaction from the legislator has been to introduce new crime classifications and investigate the need for even more. The purpose with this essay is to map and investigate the different kinds of fraudulent crimes that have been introduced the last couple of decades. The possible resulting effects the introduction of different c
Debates of where and how religion should function within secular societies have intensified during the last decade as a result of immigration and a renewed visibility of religious markers and practices. Although religious freedom is a human right, there have been many incidents of perceived friction between religious and secular values. This case study aims to provide further knowledge of religion
Syftet med denna studie är att undersöka hur cellolärare i kulturskolan arbetar för att utveckla musikaliskt uttryck hos nybörjare i undervisningen, samt vilka faktorer som påverkar dem att lägga vikt vid musikaliskt uttryck för nybörjare. Förhoppningen är att genom studien belysa vikten av diskussion inom musikpedagogik kring musikaliskt uttryck i undervisning av nybörjare. Tre cellolärare på oli
