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The presentation and underlying pathophysiology of type 2 diabetes (T2D) is complex and heterogeneous. Recent studies attempted to stratify T2D into distinct subgroups using data-driven approaches, but their clinical utility may be limited if categorical representations of complex phenotypes are suboptimal. We apply a soft-clustering (archetype) method to characterize newly diagnosed T2D based on

This report presents the findings from a pre-study concerning the opportunities and challenges of digitalization and automation in bridge design. The project approach is divided into three parts: 1) a short review of the relevant literature, 2) investigations concerning bridge industry perspectives (with focus on bridge consultants), and 3) the identification of future research needs based on part

Multi-nucleotide variants (MNVs), defined as two or more nearby variants existing on the same haplotype in an individual, are a clinically and biologically important class of genetic variation. However, existing tools typically do not accurately classify MNVs, and understanding of their mutational origins remains limited. Here, we systematically survey MNVs in 125,748 whole exomes and 15,708 whole

This article discusses the politics of “direct- action” against fossil fuels put forward by climate justice movements, focusing in particular on the tactic of the blockade. Drawing on the conceptual toolkit of Urban Political Ecology, the argument moves from a critique of the consensual regime of climate change governance to highlight conflict and dissent as central forces for the transformation o

Identities fundamental to the self, such as race and gender, can operate through visual markers on the body. Identities related to a person’s heritage, or nationality, can also become visible. However, when physical appearance means that a person can pass as a member of a dominant group, being identified or ‘marked’ as other takes place through language use. In migration contexts, situations where

Stress is a public health concern. One of the explanations to why women, more than men, receive stress-related diagnosis in connection to sickness absence is their responsibility for housework and caregiving. We investigate men’s and women’s time allocation and its association with everyday stress across life course stages (25-74 years), using individual time diary data (N=11,880) from the 2000/01

Due to the increasing share of older people worldwide, the United Nations has directed an initiative towards a "decade of healthy ageing" to promote "age-friendly environments". This study aims to gain a deeper understanding of how to promote social participation and everyday mobility in later life. The ambition is to increase the knowledge about how to create more age-friendly environments and soDue to the increasing share of older people worldwide, the United Nations has directed an initiative towards a "decade of healthy ageing" to promote "age-friendly environments". This study aims to gain a deeper understanding of how to promote social participation and everyday mobility in later life. The ambition is to increase the knowledge about how to create more age-friendly environments and so

Det globala akademiska landskapet har förändrats avsevärt sedan 1990-talet. Idag deltar fler länder än någonsin i produktionen av forskning av hög kvalitet, och internationella samarbeten inom högre utbildning har ökat markant under de senaste tre årtiondena på grund av globalisering och ökad personmobilitet. Det är tydligt att internationella utbyten och ökad personmobilitet har stärkt Sveriges fThe global academic landscape has changed significantly since the 1990s. Today, more countries than ever participate in the production of high-quality research, and international collaborations in higher education have increased dramatically over the past three decades due to globalization and increased personal mobility. It is clear that international exchanges and increased personal mobility hav

Accelerated deterioration of the constituting materials is important for the long-term performance of bridges or any other load-bearing structure with several-decades-long service life. In addition to the economic consequences due to increased maintenance and repair needs, severe deterioration can lead to catastrophic collapses with possible injuries, life losses, and impairments to infrastructure

Over the years, Carbon Capture and Sequestration (CCS) has been recognized as a crucial element in the toolkit of measures to combat climate change. At the European Union (EU) level, CCS plays a vital role in climate policy, particularly in reducing CO2 emissions from hard-to-abate industries. However, no comprehensive legal framework covers all stages of CCS. These stages include carbon capture t

Involving older people through co-design has become increasingly attractive as an approach to develop technologies for them. However, less attention has been paid to the internal dynamics and localized socio-material arrangements that enact this method in practice. In this paper, we show how the outcomes that can be achieved with user involvement often pertain to learning, but their content can di

Cells have an incredible ability to physically interact with neighboring cells and their environment. They can detect and respond to mechanical forces by converting mechanical stimuli into biochemical signals in a process known as mechanotransduction. This is a key process for the adaption of vascular smooth muscle and endothelial cells to altered flow and pressure conditions. Mechanical stimuli,

The division between rural and urban values and practices is a classic theme in disciplines such as European ethnology. During the last decades, the urban/rural divide seem to be renegotiated. Traditional, small scale agriculture and food production encapsulates values on display at many dinner tables of the upper middle urban class. This has lead to new business opportunities for rural actors, of

In recent years, there has been a wave of opposition to feminism, gender equality, and minority rights in various national and international contexts. While there is a growing number of works that examine anti-gender campaigns, less attention has been devoted to the potential consequences of the anti-gender mobilizations for the internal relations within socially progressive (feminist and LGBTQ+) In recent years, there has been a wave of opposition to feminism, gender equality, and minority rights in various national and international contexts. While there is a growing number of works that examine anti-gender campaigns, less attention has been devoted to the potential consequences of the anti-gender mobilizations for the internal relations within socially progressive (feminist and LGBTQ+)

The present article explores the implication of fairness as a regulatory and competition law concept applied to digital and Artificial Intelligence markets, in light of recent law and policy developments targeting the interaction between data, market power and competition law. Much of the policy discussions, legislative proposals as well some emerging case law elevate the matter of “fairness” in tThe present article explores the implication of fairness as a regulatory and competition law concept applied to digital and Artificial Intelligence markets, in light of recent law and policy developments targeting the interaction between data, market power and competition law.Much of the policy discussions, legislative proposals as well some emerging case law elevate the matter of “fairness” in th

This paper introduces a new framework – RoadRAT - to calculate the probability of inundation, wave runup, and storm erosion impacting coastal roads. Extreme value analysis is applied to annual maxima of observed and simulated still water level levels (SWL), total water levels (SWL + runup), and storm erosion volumes. The probability of impact on the road is derived both for the present conditions

Positive Energy Districts (PEDs) have rapidly emerged as a dominant policy instrument in Europe to accelerate urban climate transitions. PEDs target the district scale to optimise energy system performance through a combination of technical and social interventions. These activities are driven by an engineering logic that considers energy infrastructures to be rational, integrated, and governable.

En järnväg kommer till en ort som tidigare saknat tågtrafik. En station ska byggas och passas in i en befintlig struktur. Nya möjligheter till att pendla skapas, till arbetsplatser och utbildning på andra orter. Fler får också möjlighet att besöka orten tack vare järnvägen. Under järnvägsbyggandets guldålder för drygt 100 år sedan kunde orter få en enorm tillväxt tack vara den nya förbindelsen ochThe places close to where a new railway line and new stations are established, are hugely affected by the arrival of this new mode of transportation. New possibilities to travel further in the same time as before, or the same distance in half the time, significantly increases the opportunities for both commuting and for visiting places. Historically, new villages or even towns have sprung up as