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First Steps towards Evidence-Based Preventive Home Visits: Experiences Gathered in a Swedish Municipality.

The purpose of preventive home visits is to promote overall health and wellbeing in old age. The aim of this paper was to describe the process of the development of evidence-based preventive home visits, targeting independent community-living older persons. The evidence base was generated from published studies and practical experiences. The results demonstrate that preventive home visits should b

The Swedish Malignant Middle cerebral artery Infarction Study: Long-term results from a prospective study of hemicraniectomy combined with standardized neurointensive care

Hemicraniectomy in patients with malignant middle cerebral artery (mMCA) infarct may be life-saving. The long-term prognosis is unknown. Patients with mMCA infarct treated with hemicraniectomy between 1998 and 2002 at three hospitals were included. The criterion for surgical intervention was if the patients deteriorated from awake to being responding to painful stimuli only. All patients were foll

Regulation of PKCalpha and the role of PKC in neuroblastoma cell migration

Members of the protein kinase C (PKC) family of serine/threonine kinases play critical roles in cellular regulation. Depending on differences in regulation, PKCs can be divided into classical (alpha, betaI, betaII and gamma), novel (delta, epsilon, eta and theta) and atypical (zeta and iota/lambda) isoforms. When PKCalpha is inactive it is maintained in a closed conformation by intramolecular inte

Does aspirin protect against Alzheimer's dementia? A study in a Swedish population-based sample aged >= 80 years

Objective. It has been reported that aspirin and other non-steroidal anti-inflammatory drugs (NSAID) may protect against dementia of Alzheimer's type and/or vascular dementia. However, co-morbidity and the dose of aspirin may be critical. A major indication for low-dose aspirin is prophylaxis after stroke and transient ischaemic attacks, conditions that may obscure an anti-dementia effect by the d