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Background & Aims Predniso(lo)ne, alone or in combination with azathioprine, is the standard-of-care (SOC) therapy for autoimmune hepatitis (AIH). However, the SOC therapy is poorly tolerated or does not control disease activity in up to 20% of patients. We assessed the efficacy of mycophenolate mofetil (MMF) and tacrolimus as second-line therapy for patients with AIH. Methods We performed a r

This thesis presents applications of the Scheimpflug Lidar (S-Lidar) method. The technique has been applied to combustion diagnostics on a scale of several meters as well as fauna detection and monitoring over distances of kilometers. Lidar or laser radar is a remote sensing technique where backscattering of laser light is detected with range resolution along the direction of the laser beam. It is

The global carbon cycle experienced a major perturbation during the Permian-Triassic transition, reflected inter alia in a large increase in the vertical (shallow-to-deep) gradient of carbonate δ13C (δ13Ccarb) in Early Triassic seas. However, the effect of this perturbation on the vertical gradient of organic matter δ13C in seawater (δ13Corg) is less known to date. Here, we examine geographic and

Late Permian mass extinction (LPME) research has focused primarily on Tethyan sections because it is believed that these successions are more complete than those from other localities, and provide a more comprehensive record of the largest, most devastating extinction event in Earth history. The Kisejin section, a previously undocumented mid-Tethyan, Upper Permian-Lower Triassic succession located

Climate change is a global and demanding issue, which affects all the states on the planet. The European Union has from the 90s been vigorously engaged in the international efforts to tackle climate change and even pursued to take on the leading role in the global climate regime. The two most anticipated UN conferences for combating climate change at the global level were the COP15 in 2009 and COP

Purpose: The purpose of the thesis is to explore how the ownership transfer from a developed country to a developing country influences consumers’ perception of the brand. Design/methodology/approach: After the extensive review of the literature about the concept of country of origin and brand image, three premium automobile brand acquisition cases (Jaguar, Land Rover and Volvo) were investigated.

Under 1900-talet såg världen omfattande lidande bland mänskligheten i flera länder, vilka kulminerade i folkmord och massakrer under 1990-talet. Ett sätt som identifierades för att få ett slut på grymma brott var humanitära interventioner. En kommission, The International Commission on Intervention and State Sovereignty (ICISS), tillsattes år 2001 för att utreda begreppet. De presenterade i decembDuring the 20th century, the world saw humans suffering in many countries around the world. These sufferings ended in genocide and massacres during the 1990s. One way that was identified to end atrocity crimes was humanitarian interventions. A commission, The International Commission on Intervention and State Sovereignty (ICISS), was appointed in 2001 to investigate the concept. They presented a n

Sektion 52 i Copyright Designs and Patents Act innebär att det upphovsrättsliga skyddet i Storbritannien, vilket garanterar upphovsmannen ett skydd för 70 år efter hans död, minskar till 25 år efter att verket satts på marknaden om det upphovsskyddade verket har massproducerats. Storbritanniens lagstiftning skiljer sig från regleringen i övriga Europa eftersom resterande länder inte har samma undaThe foundational copyright protection in the United Kingdom provides the creator with a protection of 70 years after the death of the creator. Section 52 of the Copyright Designs and Patents Act reduces the copyright protec-tion, if the piece has been mass produced industrially, to a protection of 25 years after the product has been put on the market. The British government has during 2013 decided

Problem Definition: Ericsson wants to increase their focus on reducing the total cost of packaging for the company in the whole world. They want to create a simple calculation model that can calculate the total packaging cost and compare different packaging solutions (country, freight, packaging, and product) in order to find the most cost effective packaging solution. This will facilitate the dev

Nowadays new tools became available for global actors for achieving their goals, which are not only traditional military means (hard power) and/or the means of seduction (soft power). Instead, the new tools, which are more sophisticated and effective in implementing the power by the actor, are currently being applied in order for an actor to effectively influence its counterparts (from individuals

BACKGROUND: Endolichenic fungi are microbes that inhabit the thalli of lichens and produce various unique chemicals that can be used for pharmaceutical purposes.PURPOSE: This study screened a library of endolichenic fungal extracts to identify novel anticancer agents capable of suppressing the tumorigenicity of human cancer cells.METHODS: Active compounds were isolated from extracts of endolicheni

The carotid-to-femoral pulse wave velocity, determined by pulse transit time (PTT) and distance, is a well-established measure of arterial stiffness and predicts adverse outcomes. However, its predictive value decreases with aging. To explore new risk indicator in the elderly, we investigated if the variation of carotid-to-femoral pulse wave velocity, registered as beat-to-beat variability of caro

Climate warming is expected to accelerate glacier retreat and shift hydrological regime, which poses great threat to regional water resources in terms of amount, variability, and quality. This is especially true in arid regions with glaciers such as the Central Asia. However, few models manage to mimic both glacier runoff and surface changes with adequate performance. To narrow this gap, we integ

Muscarinic acetylcholine receptors (mAChRs) play a central role in the mammalian nervous system. These receptors are G protein-coupled receptors (GPCRs), which are activated by the agonists acetylcholine and muscarine, and blocked by a variety of antagonists. Mammals have five mAChRs (m1-m5). In this study, we cloned two structurally related GPCRs from the fruit fly Drosophila melanogaster, which,