Sökresultat

Filtyp

Din sökning på "*" gav 531139 sökträffar

Deformable particles with anisotropic interactions: unusual field-induced structural transitions in ultrasoft ionic microgel colloids

Ionic microgels are intriguing soft and deformable colloids with an effective pair potential that crosses over from Yukawa-like at large distances to a much softer repulsive interaction at short distances. Here we report the effect of adding an anisotropic dipolar contribution to colloids with such "ultra-soft" interactions. We use an alternating electric field to induce a tunable dipolar contribu

New aspects of tissue mast cells in inflammatory airway diseases

Mast cell are found throughout the body, but are especially prominent in tissues that have direct contact with the external milieu such as the skin, gastrointestinal tract and lungs. Mast cells are commonly recognized for their detrimental role in allergic reactions and can, upon activation through the high-affinity receptor for IgE (FcεRI), rapidly produce and secrete many of the mediators respon

A Conceptual Framework to Support Engineering Designers in Using In-Service Information

Abstract in Undetermined In the global market of air transport, the integration of products and services is seen as being necessary for the long-term success of engine manufacturers. A flow of in-service information to designers is crucial for minimising in-service issues. A literature review showed that there are no studies that have proposed or developed methods or tools to support designers in

Evaluation of an immunoaffinity extraction column for enrichment of adducts between human serum albumin and hexahydrophthalic anhydride in plasma.

An immunoaffinity extraction (IAE) column was prepared for extraction of adducts between human serum albumin (HSA) and hexahydrophthalic anhydride (HHPA). HHPA is a strong sensitizer inducing immunoglobulin E antibodies in vivo. Polyclonal antibodies from a rabbit immunized with keyhole limpet hemocyananin-HHPA conjugate were purified using a Protein A Sepharose gel. To obtain antibodies with opti

Epidermal growth factor receptor (EGFR) and the estrogen receptor modulator amplified in breast cancer (AIB1) for predicting clinical outcome after adjuvant tamoxifen in breast cancer.

The epidermal growth factor receptor (EGFR) and the estrogen receptor (ER) modulator Amplified In Breast cancer-1 (AIB1) have been reported to be of importance for the prognosis of breast cancer patients. We have analyzed AIB1 and EGFR by immunohistochemistry in primary breast cancers (n = 297) arranged in a tissue microarray in order to predict outcome after adjuvant endocrine therapy with tamoxi

IT-kvalitet i praxis: systemutvecklares kunskap om och syn på kvalitet

Popular Abstract in Swedish Alla har vi väl någon gång varit med om att datorer, dataprogram och datasystem inte fungerar som vi har tänkt oss. Inte sällan inträffar det fel och konstigheter som kan vara frustrerande och, i värsta fall, direkt farliga. Många gånger undrar man hur ett visst program eller system skall användas och hur de som har designat och byggt det har tänkt och resonerat. I stoThis work is about IT quality and systems developers' knowledge and view of it. IT quality is considered as the characteristics of a system or program that influence e.g. the experience of using it, the easiness to learn and understand it, how it could be customised according to new demands, and the possibility for those who have developed it to understand how it works and can be enhanced. There a

On the Coulomb potential in dimension one

a mathematically rigorous definition of the one-dimensional Schrodinger operator -d(2)/dx(2)-gamma/x is given, It is proven that the domain of the operator is defined by the boundary conditions connecting the values of the function on the left and right half-axes. The investigated operator is compared with the Schrodinger operator containing the Coulomb potential -gamma/x.

Extremal Control of Wiener Model Processes

Extremal control of Wiener type processes is considered. These models consists of a linear part followed by a static nonlinearity. We will consider nonlinearities having one extremum point. The purpose is to keep the output of the process as close as possible to the extremum point. The main problem in the control of this kind of processes is the non-uniqueness of the inverse of the nonlinearity. T

Pathway-specific bidirectional regulation of Ca2+/calmodulin-dependent protein kinase II at spinal nociceptive synapses after acute noxious stimulation.

An intensely painful stimulus may lead to hyperalgesia, the enhanced sensation of subsequent painful stimuli. This is commonly believed to involve facilitated transmission of sensory signals in the spinal cord, possibly by a long-term potentiation-like mechanism. However, plasticity of identified synapses in intact hyperalgesic animals has not been reported. Here, we show, using neuronal tracing a

Radiological changes in asbestos cement workers

OBJECTIVE--To explore associations between exposure to asbestos cement dust and radiographic findings in lung parenchyma and pleura. METHODS--Radiographs from 174 blue collar workers and 29 white collar workers from an asbestos cement plant formed one part of the study. Progression of small opacities was further studied in those 124 blue collar workers, for whom two radiographs taken after the end

Composite Material Based on Macroporous Polyaniline and Osmium Redox Complex for Biosensor Development

Here the feasibility of layers based on the conducting polymer polyaniline (PANI) as component of glucose biosensors using glucose oxidase (GOx) as enzyme and [Os(bpy)(2)(4-aminomethylpyridine)Cl]PF6 (OsCmplx) as electrochemical mediator, is evaluated. Particularly, PANI was employed to obtain a nanostructured macroporous material (m-PANI) around polystyrene nanoparticles taken as template and the

Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland

Background: Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland) and Greenland (N = 1,103) between the years 2002 and 2012, we examined relations of prenatal exposure to 1,

Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis

A 4-year-old boy presented with proteinuria and developed progressive renal failure over 6 years. In the patient's family, five individuals were affected with atypical haemolytic uraemic syndrome (aHUS) but not the patient. Renal biopsies (n = 3) showed glomerular basement membrane thickening with double contours, endothelial swelling and deposits of C3 and C1q. Electron microscopy revealed mesang

A 24-Hour Study of the Hypothalamo-Pituitary Axes in Huntington's Disease.

Huntington's disease is an inherited neurodegenerative disorder characterised by motor, cognitive and psychiatric disturbances. Patients exhibit other symptoms including sleep and mood disturbances, muscle atrophy and weight loss which may be linked to hypothalamic pathology and dysfunction of hypothalamo-pituitary axes.

Gene and Protein Expression in Human Gliomas

The human gliomas are the most common primary brain tumours. They are highly aggressive with a rapid fatal progression for the patient. The invasive growth pattern and inherent resistance to radiation and chemotherapy account for a lack of efficient therapies. Several novel therapeutic regimes are being investigated, but they have so far shown limited beneficial effects. The molecular heterogeneit

Visual flight control in naturalistic and artificial environments.

Although the visual flight control strategies of flying insects have evolved to cope with the complexity of the natural world, studies investigating this behaviour have typically been performed indoors using simplified two-dimensional artificial visual stimuli. How well do the results from these studies reflect the natural behaviour of flying insects considering the radical differences in contrast

Effects of small-scale habitat fragmentation on predator-prey interactions in a temperate sea grass system

During the last decades, fragmentation has become an important issue in ecological research. Habitat fragmentation operates on spatial scales ranging over several magnitudes from patches to landscapes. We focus on small-scale fragmentation effects relevant to animal foraging decision making that could ultimately generate distribution patterns. In a controlled experimental environment, we tested sm