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We aimed at assessing familial risk of melanoma by considering a detailed family history of multiple primary (invasive/in situ) melanomas (MPM), stratified by histology and location.
OBJECTIVE: To describe and enhance our understanding of how persons with late effects of polio experience the influence of an interdisciplinary rehabilitation programme. PARTICIPANTS: Twelve persons with clinically verified late effects of polio who had participated in an individualized, goal-oriented, comprehensive interdisciplinary rehabilitation programme. METHODS: Qualitative research intervie
Coding principles are central to understanding the organization of brain circuitry. Sparse coding offers several advantages, but a near-consensus has developed that it only has beneficial properties, and these are partially unique to sparse coding. We find that these advantages come at the cost of several trade-offs, with the lower capacity for generalization being especially problematic, and the
Extracellular vesicle (EV)-mediated intercellular transfer of signaling proteins and nucleic acids has recently been implicated in the development of cancer and other pathological conditions; however, the mechanism of EV uptake and how this may be targeted remain as important questions. Here, we provide evidence that heparan sulfate (HS) proteoglycans (PGs; HSPGs) function as internalizing recepto
The proteoglycan NG2 plays a major role in proliferation, migration, and differentiation of pericytes and NG2 cells in the brain. We have previously reported decreased NG2 levels in cerebrospinal fluid (CSF) from patients with Alzheimer's disease (AD) and a relationship between NG2 and AD biomarkers in these patients. To further investigate whether alterations in NG2 is specific to AD pathology, w
The use of antineoplastic drugs in health care steadily increases. Health care workers can be occupationally exposed to antineoplastic drugs classified as carcinogenic or teratogenic. Monitoring of surface contamination is a common way to assess occupational exposure to antineoplastic drugs, since wipe sampling is used as a surrogate measure of dermal exposure. Since no occupational limits for ant
OBJECTIVES: To evaluate the proportion of cardiovascular disease (CVD) incidence that is explained by genetic variation at chromosome 9p21 and to test whether such variation adds incremental information with regard to CVD prediction, beyond traditional risk factors. DESIGN, SETTING AND PARTICIPANTS: rs4977574 on chromosome 9p21 was genotyped in 24 777 subjects from the Malmö Diet and Cancer study
JavaScript is a dynamically typed, object-based scripting language with runtime evaluation. It has emerged as an important language for client-side computation of web applications. Previous studies indicate some differences in execution behavior between established benchmarks and real-world web applications. Our study extends previous studies by showing some consequences of these differences. We c
This work presents a new inclusive search for supersymmetry (SUSY) by the ATLAS experiment at the LHC in proton-proton collisions at a center-of-mass energy root s = 7 TeV in final states with jets, missing transverse momentum and one or more isolated electrons and/or muons. The search is based on data from the full 2011 data-taking period, corresponding to an integrated luminosity of 4.7 fb(-1).
Using a large, new database of contractual provisions governing the allocation of cash flow rights in venture capital (VC) financings, we investigate how contract design is related to VC abilities to monitor and provide value-added services to the entrepreneur. We find that more experienced VCs, who have superior abilities and more frequently join the boards of their portfolio companies, obtain we
WNT5A has been identified as an important ligand in the malignant progression of a number of tumours. Although WNT5A signalling is often altered in cancer, the ligand's role as either a tumour suppressor or oncogene varies between tumour types and is a contemporary issue for investigators of β-catenin-independent WNT signalling in oncology. Here, we report that one of the initial effects of active
Objective: To describe health-related quality-of-life (HRQoL) and life satisfaction many years after a traumatic brain injury (TBI) and assess possible associations with variables related to the time of injury and follow-up and the individuals' self-appraisal of the impact of the TBI. Method: Sixty-seven individuals (18-65 years), on average 10 years post-injury, were interviewed. Data on HRQoL, u
Benthic foraminifera were cultured for five months at four temperatures (4, 7, 14 and 21 degrees C) to establish the temperature dependence of foraminiferal calcite delta O-18 and Mg/Ca. Two Bulimina species (B. aculeata and B. marginata) were most successful in terms of calcification, adding chambers at all four temperatures and reproducing at 7 and 14 degrees C. Foraminiferal delta O-18 values d
Impact of SBP vs. DBP decrement during orthostasis on cardiovascular events in hypertension is not clear.
Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinati
A search for scalar particles decaying via narrow resonances into two photons in the mass range 65-600 GeV is performed using 20.3 fb^{-1} of sqrt[s]=8 TeV pp collision data collected with the ATLAS detector at the Large Hadron Collider. The recently discovered Higgs boson is treated as a background. No significant evidence for an additional signal is observed. The results are presented as limits
Among Swedish families with an inherited predisposition for breast cancer, less than one third segregate mutations in genes known to be associated with an increased risk of breast cancer in combination with other types of tumours. In a search for new putative familial breast cancer syndromes we studied Swedish families undergoing genetic counselling during 1992-2000. Four thousand families from co
Transforming growth factor-beta (TGFbeta) regulates the activation state of the endothelium via two opposing type I receptor/Smad pathways. Activin receptor-like kinase-1 (ALK1) induces Smad1/5 phosphorylation, leading to an increase in endothelial cell proliferation and migration, while ALK5 promotes Smad2/3 activation and inhibits both processes. Here, we report that ALK5 is important for TGFbet
