The affinity of T-cell receptors (TCRs) for major histocompatibility complex molecules (MHCs) presenting cognate antigens likely determines whether T cells initiate immune responses, or not. There exist few measurements of two-dimensional (2D) TCR-MHC interactions, and the effect of auxiliary proteins on binding is unexplored. Here, Jurkat T-cells expressing the MHC molecule HLA-DQ8-glia-α1 and th

Background: With the implementation of a research project providing whole genome sequencing (WGS) to all pediatric cancer patients in Denmark (2016–2019), we sought to investigate healthcare professionals' views on WGS as it was actively being implemented in pediatric oncology. Methods: Semistructured interviews were carried out with pediatric oncologists, clinical geneticists, and research coordi

Background: The environment where we humans live provides the fundamental requirements we need to survive – food to eat, water to drink, and air to breathe. The quality of these elements has a major impact on human health, as they can contain substances that are detrimental to health. These we call environmental pollutants. This thesis explores the effects of exposure to air pollutants in particul

Parkinson’s Disease (PD) is the most common movement disorder and second most common neurodegenerative disease. The principal hallmark of the pathology is represented by a loss of mesencephalic Dopaminergic neurons (mesDA) that reside in the Substantia Nigra pars compacta (SNpc). Another feature of the disease is represented by formation of abnormal protein aggregates, known as Lewy Bodies (LBs),

As more offshore wind parks are commissioned, the focus will inevitably shift from a planning, construction, and warranty focus to an operation, maintenance, and investment payback focus. In this latter case, both short-term risks associated with wind turbine component assemblies, and long-term risks related to integrity of the support structure, are highly important. This research focuses on the

A prototype of wind turbines in 5 megawatt class was built and tested at the first German offshore wind energy test field in the North Sea. In order to investigate dynamic behaviors under a complex state of loads, a continuous dynamic monitoring system was implemented by Federal Institute for Material Research and Testing (BAM). It recorded structural responses and environmental/operational variab

Endothelial cells (ECs) play a key role to maintain the functionality of blood vessels. Altered EC permeability causes severe impairment in vessel stability and is a hallmark of pathologies such as cancer and thrombosis. Integrating label-free quantitative proteomics data into genome-wide metabolic modeling, we built up a model that predicts the metabolic fluxes in ECs when cultured on a tridimens

The catalytic oxidation of CO on transition metals, such as Pt, is commonly viewed as a sharp transition from the CO-inhibited surface to the active metal, covered with O. However, we find that minor amounts of O are present in the CO-poisoned layer that explain why, surprisingly, CO desorbs at stepped and flat Pt crystal planes at once, regardless of the reaction conditions. Using near-ambient pr

In the future, fifth‐generation communications system (5G) is expected to provide reasonable mobile broadband experience to high‐density users in stadium, gym, shopping mall, etc. As the fundamental limitation is attributed to the propagation environments, it is essential to understand profoundly the high‐density channels, say, the propagation channel in the environments where the user density cou

Här redovisas resultat och analyser från en webbaserad enkätundersökning som i april 2020 genomförts i fem statliga myndigheter: Arbetsförmedlingen, Energimyndigheten, Naturvårdsverket, DIGG Myndigheten för digital förvaltning och Trafikverket. Undersökningen är en första del i forskningsstudien; en uppföljande, andra enkät är planerad att skickas ut när restriktionerna på arbetsplatserna har lätt

Medical knowledge is always in motion. It moves from the lab to the office, from a press release to a patient, from an academic journal to a civil servant s desk and then on to a policymaker. These movements matter: value judgements on the validity of certain forms of know­ledge determine the direction of clinical research, and policy decisions are taken in relation to existing knowledge.The compl

This paper is concerned with educational policies on Modern languages or second foreign languages (SFL) like French, German and Spanish in Sweden. Using a typology from policy instrument theory, colloquially phrased as sermons, carrots and sticks, the paper provides an historical overview and a discussion of policy objectives and policy instruments since 1945 with a particular focus on lower secon