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Synthesis of Symmetric 3,6-Disubstituted-1,2,4,5-Tetrazines using an Activated Catalyst Prepared by the Reaction of Copper Nitrate with Excess Zinc in the Presence of Hydrazine Monohydrate
Activated Molybdenum Promoted Reduction of Nitroarenes with Hydrazine monohydrate
Testing the incorporation of bioassays into life cycle assessment: A case study on advanced wastewater treatment
PurposeAdvanced wastewater treatment (AWT) methods, such as the use of ozone (O3) and granular activated carbon (GAC), have been shown to mitigate toxic impacts on receiving waters. However, life cycle assessments (LCAs) on AWT technologies commonly evaluate toxicity through chemical analysis and conclude that the increased toxicity caused by operational inputs exceeds the reduction in toxicity vi
Who Will Shift? Learning Household Flexibility from Behavioral Patterns in Electricity Usage
This thesis develops an application-oriented framework to identify and predict residential demand-side flexibility from the temporal structure of electricity use, rather than energy totals. We construct structure-based, price-aligned labels that track shifts between peak and off-peak hours, and train three complementary models: a next-day behavioral classifier (M1) for short-horizon operations, a
User centered design of parking fee editing software
Solving simple problems can quickly grow in complexity as more and more re- quirements are added over time. Parking fee’s are no exception to this as reg- ulations, special exceptions and many other factors contribute to create quite complicated fees. This complexity can make it quite difficult for the average person to model a parking-zone in the way they have to. This thesis discusses the nature
The regulation of RNA polymerase II levels
The regulation of RNAPII levels - The RNA-polymerase II (RNAPII) controls transcription. But who controls the RNAPII? Every cell in our body depends on a process called transcription, which turns genetic instructions into messages (mRNA) that can be used to make proteins. This essential job is carried out by a molecular machine known as RNA polymerase II (RNAPII). While many studies have investig
Characterization of Air-Liquid Interface Culture from Human-Derived Airway Cells on Electrospun Polycaprolactone
In vitro airway epithelial models play a crucial role in respiratory research, particularly for studying barrier function, drug delivery, and host-pathogen interactions. This thesis aimed to characterize electrospun polycaprolactone (e-PCL) in a 96-well plate format as a potential platform for supporting the attachment, proliferation, and differentiation of human airway epithelial cells (Calu-3) u
Analysis of causal mutations in barley identifies xan-c as encoding a PLS-PPR protein
From green to pale yellow: Genetics of barley chlorophyll deficiency. Barley (Hordeum vulgare L.) is the fourth-largest grain crop in the world, making it one of the most economically important cereals. Today, it is mainly used in both animal feed and brewing. Because barley grows in many different environments and has been cultivated for thousands of years, it has also become an important model
The role of the receptor PD1 in regulating tumor-specific T cell accumulation in atherosclerotic mouse aortas
Hur kan cancerbehandling öka risken för hjärt- och kärlsjukdomar? PD1-inhibitorer är en revolutionerande, ny typ av cancerbehandling som gör immunförsvaret starkare och ihärdigare i kampen mot tumörer. Tyvärr kan denna behandling leda till immunaktivering mot kroppens egna organ, till exempel hjärtat och kärlväggen. PD1-inhibitorer har visat sig öka risken för dessa sjukdomar markant, bland annatAtherosclerosis, the formation of inflammatory plaques in the arterial walls, is the most common underlying cause behind cardiovascular disease (CVD). The risk of atherosclerosis has been shown to increase following immune checkpoint inhibitor therapies such as anti-PD1. Anti-PD1 therapy has revolutionized cancer treatment as it blocks the immune checkpoint receptor PD1, preventing T cell exhausti
Optimized Multiplex Probe Design Enables MERFISH-Based Spatial Transcriptomics Across Multiple Species
Deciphering where genes are expressed within the complex architecture of cells and tissues requires advanced spatial transcriptomics techniques. This study focuses on Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH), a technique for spatial transcriptomic. The MERFISH experiment involves probes binding to specific RNA-targeted sequences within fixed cells and tissues. I develo
Migratory and wintering behaviour of the Baltic Lesser Black-backed Gull (Larus fuscus fuscus)
GPS tracking technologies are essential to follow long-distance migratory species throughout their annual cycle and identify the threats they encounter at large geographical scales. Information on the “lost” years of juvenile individuals of many species is lacking and it is vital to uncover their movements during these critical early stages. The Baltic Lesser Black-backed Gull (L. f. fuscus), a lo
A ‘Mad Ecology’: Development, Heritage, and Stewardship of Sankt Lars Cemetery
This thesis views Sankt Lars begravningsplats (cemetery) as a deathscape where histories of institutionalization, social exclusion, and neoliberal expansion are spatially materialized in the cemetery’s ecology. Tied to the former Sankt Lars asylum on the margins of Lund, Sweden, the cemetery embodies the intersections of human and nonhuman forces where ecological transformations intertwine with cu
The role of the non-coding genome in pediatric B-cell precursor acute lymphoblastic leukemia
Polycentrism, not polemics? Squaring the circle of non-discrimination law, accuracy metrics and public/private interests when addressing AI bias
Lon Fuller famously argued that polycentric issues are not readily amenable to binary and adversarial forms of adjudication. When it comes to resource allocations involving various interested parties, binary polemical forms of decision making may fail to capture the polycentric nature of the dispute, namely the fact that an advantage conferred to one party invariably involves (detrimentally) affec
Om stiftelsers exklusivitet
Om ogiltighetsinvändningar i patentintrångsmål : Analys av EU-domstolens avgörande den 25 februari 2025 i mål nr C-339/22
Procedural Ordre Public in Intra EU Investment Arbitration
Exploring Alternative Neolithization Trajectories in Northeast China (Nen River Basin)
Understanding the drivers of diversity and change in regional Neolithization trajectories has emerged as a major theme in World Prehistory with new insights appearing in many parts of the globe. In Northeast Asia, research on Neolithic transition over the past two decades has focused primarily on millet and rice domestication and their role in the rise of farming, social complexity, and early Chin
Revaccination with pneumococcal conjugate vaccine five years after primary immunization improves immunity in patients with chronic lymphocytic leukemia
Patients with chronic lymphocytic leukemia (CLL) have an impaired response to vaccination, which calls for improved vaccination strategies. This study aimed to evaluate antibody persistence 5 years after pneumococcal vaccination and response to revaccination. Seventy-four CLL patients and 31 controls, all primary immunized with 13-valent conjugated pneumococcal vaccine (PCV13) or 23-valent polysac
