The aim of this study was to describe how former male patientsperceive life after recovery from an eating disorder. A qualitativemethod with a phenomenographic approach was used toidentify ways of experiencing recovery. Two descriptive categorieswere developed: body acceptance and self-worth. Six conceptionsdescribe how recovered patients now relate in a balanced way toexercise and food, using strThe aim of this study was to describe how former male patients perceive life after recovery from an eating disorder. A qualitative method with a phenomenographic approach was used to identify ways of experiencing recovery. Two descriptive categories were developed: body acceptance and self-worth. Six conceptions describe how recovered patients now relate in a balanced way to exercise and food, usi

The fragment separator FRS at GSI was used as an energy-loss spectrometer to measure the longitudinal momentum distributions of 16,18C fragments after one-neutron removal reactions in 17,19C impinging on a carbon target at about 910 MeV/u. The distributions in the projectile frames are characterized by a FWHM of 141 ± 6 MeV/c for 16C and 69 ± 3 MeV/c for 18C. The results are compared with experime

The excitation functions for elastic α-particle scattering by 12C, 16O, 18O, and 20Ne at 180° in the c.m.s. are determined in wide energy ranges by using the new method of elastic resonance scattering on a thick target in inverse kinematics. In favorable cases, the method makes it possible to reduce considerably the time required for obtaining excitation curves. General regularities observed in th

Survivin is an oncogene that functions in cancer cell cytoprotection and mitosis. Here we report that differential expression in cancer cells of a C-terminal splice variant of survivin, termed survivin-ΔEx3, is tightly associated with aggressive disease and markers of unfavorable prognosis. In contrast to other survivin variants, survivin-ΔEx3 localized exclusively to nuclei in tumor cells and was

DNA double-strand breaks (DSB) are the most cytotoxic lesions induced by topoisomerase II poisons. Nonhomologous end joining (NHEJ) is a major pathway for DSB repair and requires DNA-dependent protein kinase (DNA-PK) activity. DNA-PK catalytic subunit (DNA-PKcs) is structurally similar to PI-3K, which promotes cell survival and proliferation and is upregulated in many cancers. KU-0060648 is a dual

Retinoid-related molecules (RRM) are novel agents with tumor-selective cytotoxic/antiproliferative activity, a different mechanism of action from classic retinoids and no cross-resistance with other chemotherapeutics. ST1926 and CD437 are prototypic RRMs, with the former currently undergoing phase I clinical trials. We show here that ST1926, CD437, and active congeners cause DNA damage. Cellular a

Trabectedin (ET-743, Yondelis) is a natural marine compound with antitumour activity currently undergoing phase II/III clinical trials. The mechanism of the drug's action is still to be defined, even though it has been clearly demonstrated the key role of Nucleotide Excision Repair (NER). To get further insights into the drug's mode of action, we studied the involvement of the DNA-double strand br

Drug design based on the structure of specific enzymes playing a role in carcinogenesis, e.g. tyrosine kinases, has been successful at identifying novel effective anticancer drugs. In contrast, no success has been achieved in drug design attempts, in which transcription factors or DNA-transcription factor complexes involved in the pathogenesis of human neoplasms were targeted. This failure is like

We argue that the current system of agri-environment management in the European Common Agricultural Policy is ineffective at conserving biodiversity in part because it promotes fragmentation instead of collaboration of actors, thus hindering coordinated biodiversity management. Actor fragmentation is reinforced by the Common Agricultural Policy (CAP) in three ways: (1) through targeting individual

The exploration of exotic nuclei is one of the most intriguing and fastest expanding fields in modern nuclear physics. In the extreme conditions of unsymmetric neutron-proton distributions and small binding energies many nuclear phenomena not encountered closer to stability have revealed themselves, often as a surprise to the nuclear physics community, the prime example being the development of ha

PURPOSE. The purpose of this study was to clinically characterize patients with CNGA3-linked achromatopsia (CNGA3-ACHM) in preparation of a gene therapy trial. METHODS. Thirty-six patients (age 7-56 years) with complete (cACHM) or incomplete (iACHM) CNGA3-ACHM were examined, including detailed psychophysical tests, extended electrophysiology, and assessment of morphology by fundus autofluorescence

There is a growing body of literature showing that health in infancy has a strong influence on health and productivity later in life. This paper uses exogenous improvements in infant health generated by the introduction of a medical innovation in the late 1930s as treatment against several infectious diseases, in particular pneumonia reduced by the advent of the sulfa medicaments. Based on rich ad

International bi-lateral agreements to support the conservation of rainforests to reduce greenhouse gas emissions are growing in prevalence. In 2009, the governments of Guyana and Norway established Guyana’s Low Carbon Development Strategy (LCDS). We examine the extent to which the participation and inclusion of Guyana’s indigenous population within the LCDS is being achieved. We conducted a singl

IMPORTANCE The majority of individuals with type 1 diabetes do not meet recommended glycemic targets. OBJECTIVE To evaluate the effects of continuous glucose monitoring in adults with type 1 diabetes treated with multiple daily insulin injections. DESIGN, SETTING, AND PARTICIPANTS Open-label crossover randomized clinical trial conducted in 15 diabetes outpatient clinics in Sweden between February