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Energy metabolic changes in the early post-injury period following traumatic brain injury in rats

Impaired cerebral energy metabolism may be a major contributor to the secondary injury cascade that occurs following traumatic brain injury (TBI). To estimate the cortical energy metabolic state following mild and severe controlled cortical contusion (CCC) TBI in rats, ipsi-and contralateral cortical tissues were frozen in situ at 15 and 40 min post-injury and adenylate (ATP, ADP, AMP) levels were

Animal modelling of traumatic brain injury in preclinical drug development : where do we go from here?

Traumatic brain injury (TBI) is the leading cause of death and disability in young adults. Survivors of TBI frequently suffer from long-term personality changes and deficits in cognitive and motor performance, urgently calling for novel pharmacological treatment options. To date, all clinical trials evaluating neuroprotective compounds have failed in demonstrating clinical efficacy in cohorts of s

Interleukin-33 Promotes Recruitment of Microglia/Macrophages in Response to Traumatic Brain Injury

Traumatic brain injury (TBI) is a devastating condition, often leading to life-long consequences for patients. Even though modern neurointensive care has improved functional and cognitive outcomes, efficient pharmacological therapies are still lacking. Targeting peripherally derived, or resident inflammatory, cells that are rapid responders to brain injury is promising, but complex, given that the

Water in Kazakhstan, a key in Central Asian water management

Central Asia is one of the regions with the highest probability of conflicts over water. Kazakhstan is the main Central Asian economic power and therefore it is important to understand how the country’s water management policy is influencing water availability in the other Central Asian states. Already, the Central Asian economies are developing under increasing water deficiency, resulting in deve

An Efficient Algorithm for Matrix-Valued and Vector-Valued Optimal Mass Transport

We present an efficient algorithm for recent generalizations of optimal mass transport theory to matrix-valued and vector-valued densities. These generalizations lead to several applications including diffusion tensor imaging, color image processing, and multi-modality imaging. The algorithm is based on sequential quadratic programming. By approximating the Hessian of the cost and solving each ite

Welcome to Hipsterville, In search of urban sustainable tourism.

Hipsterville has many locations, primarily in Europe and North America. The name of this ”place” refers tourban districts, mainly in large cities, which are dominated by particular subcultures. They are often formerworking class districts, in different stages of gentrification, located away from traditional tourism disticts. Inthese districts, clusters of small scale innovative firms may develop,

Family, Gender, and New Constellations: Crises and Changing Configurations in Late Đổi Mới Vietnam.

This chapter explores the ways in which ‘the family’ (gia đình) in late Đổi Mới Vietnam is undergoing transformations as a political institution, social organization, and lived experience. The notion of crisis, the chapter argues, provides an analytical vantage point to capture discrepancies between the ways in which the family is construed ideologically at the systemic level and how family life i

Contrasting patterns of Andean diversification among three diverse clades of Neotropical clearwing butterflies

The Neotropical region is the most biodiverse on Earth, in a large part due to the highly diverse tropical Andean biota. The Andes are a potentially important driver of diversification within the mountains and for neighboring regions. We compared the role of the Andes in diversification among three subtribes of Ithomiini butterflies endemic to the Neotropics, Dircennina, Oleriina, and Godyridina.

Mitophagy : A Mechanism for Plant Growth and Survival

Mitophagy is a conserved cellular process that is important for autophagic removal of damaged mitochondria to maintain a healthy mitochondrial population. Mitophagy also appears to occur in plants and has roles in development, stress response, senescence, and programmed cell death. However, many of the genes that control mitophagy in yeast and animal cells are absent from plants, and no plant prot

On the Calculation of SAXS Profiles of Folded and Intrinsically Disordered Proteins from Computer Simulations

Solution techniques such as small-angle X-ray scattering (SAXS) play a central role in structural studies of intrinsically disordered proteins (IDPs); yet, due to low resolution, it is generally necessary to combine SAXS with additional experimental sources of data and to use molecular simulations. Computational methods for the calculation of theoretical SAXS intensity profiles can be separated in

Experimental validation of a thermal model for high speed switched reluctance machines for traction application

This article presents the experimental validation of a novel cooling concept applied to a high speed switched reluctance machine topology for traction applications. By circulating the coolant in between the coils and the stator poles the winding and the stator iron are virtually thermally decoupled. A number of test motorettes are used to demonstrate the potential of the cooling concept at current

Reshaping Boundaries: Family Politics and GLBTQ Resistance in Urban Vietnam

Journal of GLBT Family StudiesAlthough Vietnamese society is currently undergoing significant changes with regards to the rights and perceptions of gay, lesbian, bisexual, transgender, and queer (GLBTQ) people, dominant socio-cultural norms related to gender, sexuality, and the importance of the patrilineal family regime continue to cast a shadow over the lives of GLBTQ in contemporary Vietnam. Based on ethnographic fieldwork

Plastic recycling in the Nordics: A value chain market analysis

There is low utilisation of plastic waste in the Nordic region and only a fraction of plastic materials go back into production processes through reuse and recycling practices. This paper aims to increase knowledge concerning factors that inhibit demand for recycled plastics, and to identify critical barriers for plastic recycling across the regional plastics value chain. A literature review and t

Achieving predictable and low end-to-end latency for a cloud-robotics network

To remain competitive in the field of manufacturing today, companies must make their industrial robots smarter and allow them to collaborate with one another in a more effective manner. This is typically done by adding some form of learning, or artificial intelligence (AI), to the robots. These learning algorithms are often packaged as cloud functions in a remote computational center since the amo

CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression : A study of fully automated immunoassays in BioFINDER and ADNI cohorts

Introduction: We studied whether fully automated Elecsys cerebrospinal fluid (CSF) immunoassay results were concordant with positron emission tomography (PET) and predicted clinical progression, even with cutoffs established in an independent cohort. Methods: Cutoffs for Elecsys amyloid-β1–42 (Aβ), total tau/Aβ(1–42), and phosphorylated tau/Aβ(1–42) were defined against [18F]flutemetamol PET in Sw

Pulsed electric fields in combination with vacuum impregnation for improving freezing tolerance of vegetables

Freezing is a widely used method of preserving food products. Efforts are currently being directed towards improving the quality of sensitive tissues of plant foods such as leaves, after freezing and thawing. One of the methods under investigation is the combination of vacuum impregnation (VI) with cryoprotectants and the application of a pulsed electric field (PEF) to the plant tissue prior to fr