Cdk9 is the catalytic core of the positive transcription elongation factor b (P-TEFb) and regulates transcriptional elongation factors by phosphorylation of RNA pol II. Apart from its role on myogenic gene expression, Cdk9 regulation of muscle-specific microRNAs in the early stage of cardiomyogenesis is poorly understood. Here we demonstrate that Cdk9 not only regulates myogenic transcription fact

Current methods for antibody structure prediction rely on sequence homology to known structures. Although this strategy often yields accurate predictions, models can be stereo-chemically strained. Here, we present a fully automated algorithm, called AbPredict, that disregards sequence homology, and instead uses a Monte Carlo search for low-energy conformations built from backbone segments and rigi

The synthesis of two conformationally restricted Cr(III) salen complexes, 2 and 3, is described. Together, they constitute a supramolecular hydrogen-bonding catalytic system for the recently reported asymmetric ring-opening reactions of epoxides by a dynamic supramolecular catalyst. The synthesis involves state-of-the art transformations in frontline synthetic chemistry applied to heterocyclic che

This paper describes a teaching experience of information systems (IS) analysis and design unit. In this unit every student applies a socio-technical (ST) toolbox in a real life business. These projects give students experience of real world business practices, issues and processes and provide opportunities to create a stimulating learning environment. At the same time the projects help involved b

Changes in bone matrix composition are frequently found with bone diseases and may be associated with increased fracture risk. Bone is rich in the trace element zinc. Zinc was established to play a significant role in the growth, development, and maintenance of healthy bones; however, the mechanisms underlying zinc effects on the integrity of the skeleton are poorly understood. Here, we show that

The reflectivity spectrum in Vertical-cavity surface-emitting lasers (VCSELs) is investigated by replacing High Contrast Grating (HCG) layer instead of distributed Bragg reflectors (DBR) as a top mirror. In addition, the scalability feature in the HCG layer is used to design a reflector for λ = 1;300 nm. High reflectivity (>99%) mirrors in VCSELs are mandatory because of the short gain length. In

The research in this thesis investigates how atoms and molecules constituting aqueous salt solutions interact using computational approaches, namely Monte Carlo simulations and molecular dynamics simulations. In the first paper, an atomistic model was developed for aqueous solutions of sodium thiocyanate and potassium thiocyanate (NaSCN and KSCN). The model reproduced several experimentally measur

In recent works on the Enlightenment and the origin of modern Western thought, there is often a dichotomy between Moderate versus Radical Enlightenment. This essay evaluates the early experiences of freedom of print in Sweden and Denmark against the backdrop of such assertions. Sweden and Denmark were widely diverging polities but they obtained officially recognized freedom of the press at almost

The pro-apoptotic Bax isoform Bax∆2 was originally discovered in cancer patients with a microsatellite guanine deletion (G8 to G7). This deletion leads to an early stop codon; however, when combined with the alternative splicing of exon 2, the reading frame is restored allowing production of a full-length protein (Bax∆2). Unlike the parental Baxα, Bax∆2 triggers apoptosis through a non-mitochondri

Purpose: The study seeks to shed light on the generative principles of enterprising by examining the practices of enterprisers in six lifestyle enterprises in Sweden. It presents a fresh approach to the study of lifestyle enterprises, resolving a nuanced treatment of the concepts of capital and habitus as often drawn upon in studies using the social theory of Pierre Bourdieu. Design/methodology/ap

Loss of the pro-apoptotic Bcl-2 family protein Bax occurs in ~50% of hereditary nonpolyposis colorectal cancer (HNPCC) due to microsatellite instability (MSI). Recently, we found that some of the "Bax-negative" MSI tumor cells contain a functional Bax isoform, BaxΔ2, which sensitizes cells to selective chemotherapeutics. Here we show the detection of Bax microsatellite mutations and expression of

Purpose – The purpose of this study is to clarify the relation between sustainability practices and financial and market performance, and also, the role of non-financial performance outputs in this relation. Corporate sustainability is a growing area of importance for organizational development. Managing sustainability practices successfully is an imperative in achieving competitive advantage. Des

In 2017, the new SMOS-IC retrieval product of soil moisture (SM) and L-band Vegetation Optical depth (L-VOD) was developed. This product relies on a two-parameter inversion of the L-MEB model (L-band Microwave Emission of the Biosphere) which requires little ancillary information and was found to be accurate, making it very well-suited for application in agriculture, hydrology, climate and vegetat

I december 1919 utkom John Maynard Keynes med sin varning för konsekven- serna av Versaillesfreden, The Economic Consequences of the Peace. Boken gjorde honom i ett slag världsberömd. Den översattes snabbt till svenska och kommenterades av ledande svenska nationalekonomer som David Davidson, Gustav Cassel och Eli Heckscher. De ställde sig alla helhjärtat bakom Keynes budskap. Knut Wicksell däremot