Popular Abstract in Swedish Protein kinas C (PKC) är en familj serin/treonin kinaser som har en viktig roll i regleringen av olika funktioner i cellen. PKC kan delas in i klassiska (alpha, betaI, betaII and gamma), nya (delta, epsilon, eta and theta) och atypiska (zeta and iota/lambda) isoformer beroende på skillnader i hur de regleras. När PKCalpha är inaktivt bidrar intramolekylära bindningar tiMembers of the protein kinase C (PKC) family of serine/threonine kinases play critical roles in cellular regulation. Depending on differences in regulation, PKCs can be divided into classical (alpha, betaI, betaII and gamma), novel (delta, epsilon, eta and theta) and atypical (zeta and iota/lambda) isoforms. When PKCalpha is inactive it is maintained in a closed conformation by intramolecular inte

Abstract in Arabic Abstract is not available

Popular Abstract in Swedish Föreliggande avhandling behandlar dynamiken hos styckvist hyperboliska system på begränsade mänder i planet och på intervallet. Avhandlingen är baserad på tre artiklar och därutöver annat stoff. I de två första artiklarna undersöks två olika klasser av styckvisa affina och hyperboliska avbildningar på begränsade mängder i planet. För båda dessa klasser gäller att tangeThis thesis is about dynamics of piecewise hyperbolic maps on bounded sets in the plane and on the interval. It is based on the following papers: T. Persson, A piecewise hyperbolic map with absolutely continuous invariant measure, Dynamical Systems: An International Journal, 21:3 (2006), 363--378 T. Persson, Absolutely continuous invariant measures for some piecewise hyperbolic affine maps, Prep

Laser-induced autofluorescence spectra from humans were recorded in vivo at three different clinics in a study aimed at investigating the capability of this method to discriminate between malignant tumours and normal surrounding tissues. For the recordings a mobile trolley with the necessary equipment was constructed for use in an examination room or in an operating theatre environment. Laser ligh

In this paper we show the density-dependent harvest rates of optimal Bayesian foragers exploiting prey occurring with clumped spatial distribution. Rodriguez-Girones and Vasquez (1997) recently treated the issue, but they used a patch-leaving rule (current value assessment rule) that is not optimal for the case described here. An optimal Bayesian forager exploiting prey whose distribution follows

This study examines the effect of three regimens (organizations of activities) on the realism in dyad’s confidence judgments. The effect of letting the pair members first work alone when selecting an answer and/or when confidence rating the correctness of this answer was compared with working directly in pairs. No improvement in the realism of the dyads’ final confidence judgments was found as an

Visits to nest holes by birds other than their owners is a familiar phenomenon for students of breeding biology. In this study, we evaluate that behavior using a transponder reading system. Eighty-five males and females were Fitted with transponders at the end of the incubation period or just after hatching. Nest boxes were fitted with transponder readers from just after hatching until all nestlin

We give approximation and online algorithms as well as data structures for some well studied problems in computational geometry. The thesis is divided into three parts. In part one, we study problems related to guarding, exploring and searching geometric environments. We show inapproximability results for guarding lines and 2-link polygons, question stated time bounds for computing shortest watch

Measurements of DNA ploidy can be performed either with image cytometry (ICM) or flow cytometry (FCM); both methods provide independent prognostic information in primary breast cancer. The aim of the present investigation was to compare the two methods and to relate the findings to prognosis (median follow-up 42 months). Concordance in ploidy status (diploid, tetraploid, aneuploid) was obtained in

Popular Abstract in Swedish Akut bukspottkörtelinflammation (akut pankreatit - AP) är en tämligen frekvent förekommande åkomma med en årlig incidens på 300-350/100 000 invånare i Sverige. De underliggande mekanismerna för den lokalt initierande skadan i bukspottkörteln, spridning till ett systemiskt (i hela kroppen) inflammatoriskt svar och den eventuella utvecklingen av organdysfunktion (organsviAcute pancreatitis (AP) is a common disease where underlying mechanisms for the local initiating events in the pancreas, the systemic dissemination of the inflammatory response and remote organ dysfunction still are unclear. The overall aim of the thesis was to study mechanisms of the inflammatory response in AP with special emphasis on local, systemic, and distant organ injury directed at differe

In a search for new inhibitors of the IFN-γ mediated signal transduction in HeLa S3 cells using secreted alkaline phosphatase (SEAP) as reporter gene, a novel compound, designated as S14-95 was isolated from fermentations of the imperfect fungus Penicillium sp. 14-95. The compound inhibits the IFN-γ mediated expression of the reporter gene with IC50 values of 2.5~5μg/ml (5.4~10.8μM). Furthermore t

In an investigation by the Swedish Cancer Society, an expert group described the present status, critical issues and future aspects and potentials for each of nine major areas of radiation therapy research. This report deals with interactions between chemotherapy, endocrine therapy, other anti-tumour drugs and radiation.

The optimisation of image quality vs. radiation dose is an important task in medical imaging. To obtain maximum validity of the optimisation, it must be based on clinical images. Images at different dose levels can then either be obtained by collecting patient images at the different dose levels sought to investigate-including additional exposures and permission from an ethical committee-or by man