Secretagogin is a calcium-sensor protein with six EF-hands. It is widely expressed in neurons and neuro-endocrine cells of a broad range of vertebrates including mammals, fishes and amphibia. The protein plays a role in secretion and interacts with several vesicle-associated proteins. In this work, we have studied the contribution of calcium binding and disulfide-bond formation to the stability of

Integration of evolutionary and developmental biology has stimulated novel insights on the origins and maintenance of phenotypic variation. For instance, phenotypic accommodation predicts that trait covariance originates via a novel developmental input caused by genetic change in one trait, but not the other. Darwin provided a striking example of this process in the ‘lop-eared’ rabbit by demonstra

This paper presents an existence theory for solitary waves at the interface between a thin ice sheet (modelled using the Cosserat theory of hyperelastic shells) and an ideal fluid (of finite depth and in irrotational motion) for sufficiently large values of a dimensionless parameter γ. We establish the existence of a minimiser of the wave energy E subject to the constraint I=2μ, where I is the hor

Ukrainian president Viktor Iushchenko's posthumous designation of Roman Shukhevych (1907-1950), the supreme commander of the Ukrainian Insurgent Army (upa) as a Hero of Ukraine in 2007 triggered intense, and polarized debates in Ukraine and abroad, about Second World War-era Ukrainian nationalism and its place in history. Particularly sensitive are Roman Shukhevych's whereabouts in 1940-1943, when

Complement resistance is an important virulence trait of Yersinia enterocolitica (Ye). The predominant virulence factor expressed by Ye is Yersinia adhesin A (YadA), which enables bacterial attachment to host cells and extracellular matrix and additionally allows the acquisition of soluble serum factors. The serum glycoprotein vitronectin (Vn) acts as an inhibitory regulator of the terminal comple

The impact of high-flux hemodialysis on clinical outcomes remains controversial. We have previously shown that in vivo transmigrated leukocytes from patients with low-flux bioincompatible hemodialysis have an impaired capacity to upregulate CD11b at the site of interstitial inflammation. In the present study, we investigated the in vivo capacity of transmigrated monocytes and granulocytes to expre

Following the 2004-5 Orange Revolution, President Viktor Yushchenko embarked on an ambitious project to rehabilitate the Organization of Ukrainian Nationalists (OUN) and its armed wing, the Ukrainian Insurgent Army (UPA). Following the Euromaidan Revolution and Russia’s invasion of Ukraine in 2014, a more systematic effort was made to affirm these groups as a center of a new historical canonical c