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Specific Derivatization of the Active Site Tyrosine in dUTPase Perturbs Ligand Binding to the Active Site

Selective modification of one (of three) tyrosine residue per enzyme monomer leads to inactivation of dUTPase of the retrovirus equine infectious anemia virus (EIAV). The substrate dUMP and the cofactor Mg2+protects against inactivation and modification, in agreement with the study onE. colidUTPase (Vertessyet al.(1994)Biochim. Biophys. Acta1205, 146-150). Amino acid analyses of nitrated dUTPases

Att se och tänka med ritual: kontrakterande ritualer i de isländska släktsagorna

Popular Abstract in Swedish I avhandlingen utvecklas en begreppsapparat som syftar till att utvidga vetenskapens möjligheter att studera människors formaliserade praktik i såväl religiösa som profana sammanhang. Begreppet ritual blir en term att se och tänka med. Författaren applicerar sin begreppsapparat på de medeltida isländska släktsagorna där skapandet av allianser mellan personer är ett viktTo make it possible to classify an action as a ritual act we need to know exactly what constitutes it. In this thesis I try, with the aid from literature of the field called ritual studies and the sagas of Icelanders, to sort out what these constituent elements best should consist of if we want to use the term ritual as an analytical tool in the production of knowledge with scientific criteria. Ri

Effect of Turbulence and Initial Temperature Inhomogeneity on Homogeneous Charge Compression Ignition Combustion

A 0.5-liter optical HCCI engine firing a mixture of n-heptane (50%) and iso-octane (50%) with air/fuel ratio of 3 is studied using large eddy simulation (LES) and laser diagnostics. Formaldehyde and OH LIF and in-cylinder pressure were measured in the experiments to characterize the ignition process. The LES made use of a detailed chemical kinetic mechanism that consists of 233 species and 2019 re

Strain in GaP/GaAs and GaAs/GaP resonant tunnelling heterostructures

We studied the morphology of GaP/(001)GaAs and GaAs/(001)GaP heterostructures grown by metal-organic vapour-phase epitaxy and found wire-like surface undulations elongated in the [110] direction. We attribute this elongation to anisotropic lateral growth rates in the [110] and [110] directions, which are due to a different roughness of monolayer surface steps. In III-V materials grown by molecular

Essays on Network Effects and Money

Popular Abstract in Swedish Denna avhandling består av fyra separata artiklar. Den gemensamma nämnaren för alla artiklarna är att de behandlar pengar och nätverkseffekter. En vara med nätverkseffekter är en vara där nyttan av varan är beroende av hur många andra individer som använder sig av varan. Ett typexempel i litteraturen är faxmaskiner: ju fler som har en fax, desto större nytta har man av This thesis contains four separate papers in the field of monetary economics. The common basis for all the papers is that they deal with money and network effects in one way or another. Although the common basis is the same in all the articles, different approaches are used: theory, econometrics and history of economic thought. This first essay focuses on the network effect in the use of money an

Ett betydelselöst monument? : Om Sigurd Erixons Svensk byggnadskultur

A Monument Without Meaning? On Sigurd Erixon’s Swedish Building Culture Sigurd Erixon was the dominant figure of the ”old” ethnology in Sweden. In the late 1960:s the discipline took a new, anthropological turn that replaced the older ethnology characterized by studies in objects och houses, evolution and diffusion. Swedish Building Culture was one of the great monuments of this paradigm. What me

The relationship of personality dimensions as measured by the temperament and character inventory and quality of life in individuals with schizophrenia or schizoaffective disorder living in the community

The influence of personality factors on the appraisal of subjective quality of life in individuals with schizophrenia or schizoaffective disorder is not much investigated. The present study examined this relationship in a sample of 104 patients living in the community. The temperament and character inventory was used to assess personality and the Lancashire quality of life profile was used to asse

Acidification-induced chemical changes in coniferous forest soils in southern Sweden 1988-1999

Thirty-two Norway spruce [Picea abies (L.) Karst.] and Scots pine (Pinus sylvestris L.) stands in southern Sweden were studied for a period of 12 years to evaluate acidification-induced chemical changes in the soil. Soil, at 20-30 cm depth in the mineral layer, was sampled three times during this period (1988, 1993 and 1999). The results show that pH(BaCl2) in mineral soil decreased by, on average

Effects of ethanol on muscarinic receptor-stimulated c-fos expression in human neuroblastoma cells

The effect of ethanol exposure on muscarinic receptor-stimulated expression of c-fos was investigated in SH-SY5Y cells. Four days of ethanol exposure enhanced carbachol-stimulated c-fos mRNA expression, analyzed with Northern blot, and Fos/AP-1 binding activity, measured with gel mobility super shift assay. Pre-incubation with muscarinic antagonists or the protein kinase C inhibitor GF109203X demo

Multi-electron production at high transverse momenta in ep collisions at HERA

Multi-electron production is studied at high electron transverse momentum in positron- and electron-proton collisions using the H1 detector at HERA. The data correspond to an integrated luminosity of 115 pb(-1). Di-electron and tri-electron event yields are measured. Cross sections are derived in a restricted phase space region dominated by photon-photon collisions. In general good agreement is fo

Mechanics and Ca(2+)-sensitivity of human detrusor muscle bundles studied in vitro

Mechanical properties of isolated smooth muscle strips from human urinary bladder were investigated in vitro. Bladder tissue was obtained from tumour-free wall regions of bladders from male patients undergoing cystectomy for bladder carcinoma. In intact muscle strips, activated with high-K+ solution, half-maximal force occurred at about 0.9 mM extracellular [Ca2+]. The length-active force relation