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The ionophore salinomycin has attracted attention for its exceptional ability to selectively reduce the proportion of cells with stem-like properties in cancer cell populations of varying origin. Targeting the tumorigenicity of such cells is of interest as they are implicated in recurrence, metastasis, and drug resistance. Structural derivatives of salinomycin are thus sought after, both as tools
I denna publikation görs en noggrann genomgång av bakgrunden till dagens flödesbaserade samhälle med dess sårbarhet. Vidare diskuteras frågan hur flödesbaserade avbrottsrisker definieras samt hur dess konsekvenser, inklusive s.k. domino-effekter, kan beskrivas. Även de teoriområden som tar upp denna typ av risker behandlas.Dagens moderna samhälle är till stor del uppbyggt kring försörjningskedjor
Urban and peri-urban agriculture plays an important role in meeting the food and nutrition needs of those living in the increasingly urbanised cities in Africa. The extent and scope of the practise of urban and peri-urban agriculture differs from one city to another depending on the economic, environmental, socio-political, and contextual conditions at play. Using household data drawn from urban T
To better understand how to structure interdisciplinary education, there is a need to study and learn from programmes at all levels in the academic system. While considerable effort has been devoted into examining bachelor’s and master’s programmes, the challenges and rewards of doctoral programmes receive less attention. In this chapter, we present the LUCID Ph.D. research school as an example of
ZNF224 is a member of the Kruppel-associated box zinc finger proteins (KRAB-ZFPs) family. It was originally identified as a transcriptional repressor involved in gene-specific silencing through the recruitment of the corepressor KAP1, chromatin-modifying activities, and the arginine methyltransferase PRMT5 on the promoter of its target genes.Recent findings indicate that ZNF224 can behave both as
Jet impingement cooling is widely used in modern gas turbines. In the present study, both heat transfer and flow field measurements of jet impingement in cross-flow are carried out with and without a vortex generator pair (VGP). The jet and cross-flow Reynolds numbers are fixed at 15,000 and 48,000, respectively. The local heat transfer coefficients are obtained by a liquid crystal thermography (L
Eye movement modeling examples (EMME) are demonstrations of a computer-based task by a human model (e.g., a teacher), with the model's eye movements superimposed on the task to guide learners' attention. EMME have been shown to enhance learning of perceptual classification tasks; however, it is an open question whether EMME would also improve learning of procedural problem-solving tasks. We invest
The influences of operating conditions and physical properties of the two phases on the hydrodynamics and mass transfer in a circular liquid-liquid microchannel have been investigated. The polytetrafluoroethylene (PTFE) microchannel has an internal diameter of 0.7 mm and a T-shaped mixing junction. Sodium hydroxide solution was used as the aqueous phase. N-hexane and toluene were employed as the o
The cubic perovskite SrVO3 is generally considered to be a prototype strongly correlated metal with a characteristic three-peak structure of the d-electron spectral function, featuring a renormalized quasiparticle band in between pronounced Hubbard sidebands. Here we show that this interpretation, which has been supported by numerous "ab initio" simulations, has to be reconsidered. Using a fully s
This work aims to investigate the effect of liquid entrainment on liquid film dryout in annular flow for flow boiling. Entrainment and deposition rates of droplets were included in mass conservation equations to estimate the local liquid film mass flux in annular flow, and the critical vapor quality at dryout conditions. Different entrainment rate correlations were evaluated using flow boiling dat
In ESS, a pulsed proton beam of 5 MW mean power will hit a tungsten target to generate neutrons by spallation. The pulses are 2.86 ms long and occur with 14 Hz; the power within a pulse is 125 MW. Only centimeters from the target, the neutrons are moderated by liquid hydrogen in aluminium vessels. The deposited power heats the surrounding structures and fluids which are circulated and cooled. The
In the paper we discuss the following research questions: How do start-ups provide themselves with software and what are the motivations behind deciding on a specific sourcing option? The questions are motivated from the fact that acquirement of software is a challenging question, and it is especially interesting to explore how start-ups do, since they do not have a legacy to deal with. The resear
The effect of ozone (O3) in a turbulent, swirl-stabilized natural gas/air flame was experimentally investigated at atmospheric pressure conditions using planar laser-induced fluorescence imaging of formaldehyde (CH2O PLIF) and dynamic pressure monitoring. The experiment was performed using a dry low emission (DLE) gas turbine burner used in both SGT-700 and SGT-800 industrial gas turbines from Sie
