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Purpose: To evaluate the role of blood perfusion and revascularization during the healing process of periocular defects treated with laissez-faire following tumor excision. Methods: Ten patients with periocular basal cell carcinomas underwent excision, followed by laissez-faire wound management. Blood perfusion was measured using laser speckle contrast imaging postoperatively. Results: Immediately
INTRODUCTION: Large language models (LLMs) have gained increasing popularity in several medical disciplines. In orthopedic research however, their integration into routine practice have been questioned as they do not seem to outperform experienced clinicians. Conversely, research on the role of artificial intelligence in hand surgery remains limited. This study aims to evaluate two common LLMs in
BACKGROUND: Post-acute sequelae of SARS-CoV-2 infection, or long COVID, include diverse symptoms and remain a major concern worldwide. This study investigates the occurrence of depression, anxiety, fatigue, and headache 1 year prior to the COVID-19 pandemic (2019), 12 months prior to, and 6 months after long COVID diagnosis in individuals diagnosed with long COVID and matched population-based cont
Microorganisms are key players in the global cycling of nitrogen and carbon, controlling their availability and fluxes, including the emissions of the powerful greenhouse gases nitrous oxide and methane. Standard sequencing methods often reveal only a limited fraction of their diversity, because of their low relative abundance, the insufficient sequencing depth of traditional metagenomes of comple
Autocracies have increasingly begun to clothe themselves in the guise of hybrid, semi-official institutions that exhibit a degree of autonomy from the state, such as Government-Organized NGOs (GONGOs), “zombie” election observers, regime-run think tanks, astroturfing, or semi-official state-mobilized movements (SMMs). Existing literature has analyzed hybrid institutions as products of their functi
Bacterial pathogens deploy diverse virulence factors to subvert host immunity, yet the molecular details of these interactions often remain unresolved. Here, we investigate the structure and host interactome of the Streptococcus pyogenes nuclease A (SpnA). We characterized the structure and dynamics of SpnA using hydrogen-deuterium exchange mass spectrometry and single-particle electron cryo micro
Relational memory retrieval entails a dynamic interplay between eye movements and neural activity, yet the temporal coordination of these processes remains unclear. We examined how theta- and alpha-band EEG activity relates to sequential fixations during relational memory retrieval. Participants performed a two-alternative forced-choice associative memory task while eye movements and EEG were reco
Ancient DNA has revolutionized the fields of archaeology and anthropology. Nowhere is this more apparent than in the field of kinship studies. This report provides a reflection on a recent workshop focused on exploring non-biological kinship in light of recent aDNA research. It presents a summary of reflections by workshop participants that emphasized the importance of interdisciplinary collaborat
Despite substantial contextual differences between the West and China, systems approaches have been recognized as essential for addressing complex and dynamic management challenges, particularly within the field of innovation. However, most previous studies are rooted in traditional cybernetics within the framework of first-order science, which is characterized by linear processes and stable eleme
Decision biases reinforce firms’ tendency to develop innovations based on narrow economic motivations. Consequently, sustainability-oriented ideas explicitly targeting social and environmental issues are easily discarded in idea selection when trade-offs between economic and sustainability values are faced. Given the so far limited knowledge about how sustainability-oriented ideas are developed an
BACKGROUND: Diagnosing heart failure with preserved ejection fraction (HFpEF) remains challenging, particularly in older adults. While the Heart Failure Association (HFA)-PEFF and H2FPEF Scores offer structured diagnostic approaches, their clinical utility is still debated. This study aims to compare the diagnostic accuracy of HFpEF Scores versus inclusion criteria used in sodium-glucose cotranspo
Although organizational innovation capability plays a driver for the improvement of safety performance of High Reliability Organizations (HRO), knowledge management is a key link and important guarantee for them. However, there is no relevant research on how to achieve innovation of HRO through knowledge management. Previous research highlights that the dynamic and uncertain external environment o
Internal crowdsourcing offers new opportunities for ideas to gain legitimacy in idea development as not only managers but also experts are able to provide feedback to improve and subsequently accept ideas for further realisation. Given this far limited knowledge about how ideas gain legitimacy in idea development, this paper focuses on the influence of feedback, a main source of idea legitimacy in
