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Background: There is mounting evidence supporting the role of the microbiota in hypertension from experimental studies and population-based studies. We aimed to investigate the relationship between specific characteristics of the gut microbiome and 24-h ambulatory blood pressure measurements. Methods: The association of gut microbial species and microbial functions, determined by shotgun metagenom

Bakgrund: Subakromiellt smärtsyndrom (SAPS) är en vanlig orsak till axelsmärta bland unga individer som tränar over-head idrotter, såsom simning och handboll. Dysfunktion i scapulas stabiliserande muskulatur kan bidra till den symtombilden av SAPS. En ökad förståelse för muskelaktivitet hos de scapulas stabiliserande muskulatur kan ge bättre insikter i rehabilitering av SAPS. Syfte: Syftet med den

PURPOSE: This study aimed to examine the associations between the intake of high- and low-fat fermented dairy (cheese and fermented milk), their proteomic profiles, and mortality risk.METHODS: This cohort study included 25,187 participants (mean age 57.7 years, 60.9% females). Fermented dairy intake was assessed by a modified diet history method. In a random subset of this cohort (n = 4359), we co

OBJECTIVE: Autoantibodies have long been recognized as biomarkers of islet autoimmunity in type 1 diabetes, but their role in the pathogenesis is not fully understood. The aim of this study was to analyze clinical and hereditary characteristics of children presenting with and without autoantibodies at type 1 diabetes diagnosis.RESEARCH DESIGN AND METHODS: Data were collected from children (<18 yea

The Iberian ribbed newt (Pleurodeles waltl) constitutes a central model for probing the basis of vertebrate regeneration. Here, we present the sequencing and chromosome-scale assembly of the 20.3Gb P. waltl genome, which exhibits the highest level of contiguity and completeness among giant genome assemblies. We uncover that DNA transposable elements are the major contributors to its expansion, wit

Nanowires have an ideal shape for high-resolution imaging, with a small cross-section for high resolution and a long length for strong absorption. However, since the absorption in nanowires is dominated by nanophotonic effects, it is unclear what resolution and efficiency such devices could offer. Here, we investigate the limits of spatial resolution and efficiency of nanowire-based direct detecto

Objectives: Menstrual migraine (MM) is a debilitating neurological disorder triggered by fluctuations in ovarian hormones, particularly estrogen. While the calcitonin gene-related peptide (CGRP) system is central to migraine pathophysiology, the molecular mechanisms linking hormonal changes to CGRP signaling remain unclear. This study investigates how sex hormones regulate CGRP-related gene expres

Denna uppsats undersöker hur EU:s konkurrenslagstiftning reglerar interoperabilitetsskyldigheter för dominerande digitala plattformar. Uppsatsen visar hur EU-domstolens avgörande i Android Auto (C-233/23) omformar teorin om nödvändiga nyttigheter (Essential Facilities Doctrine, EFD) som etablerades i Bronner-domen (C-7/97). Vidare analyseras denna framväxande doktrins samspel med de interoperabiliThis thesis explores how EU competition law governs interoperability obligations for dominant digital platforms. It shows how the CJEU’s judgment in Android Auto (C-233/23) redefines the Essential Facilities Doctrine (EFD) established in Bronner judgment (C-7/97) and how this emerging doctrine interacts with the interoperability obligations introduced by the Digital Markets Act (DMA). The Android

Under uppsvinget av corona pandemin år 2020 läarde vi att anpassa oss till förändrade förutsättningar i samhället till större grad än tidigare. Forskare och företag världen över samarbetade för att utveckla och producera ett vaccin som skulle minska spridningen av viruset. Idag är denna pandemin nästan ett minne blott tack vare messengerRNA (mRNA)-vaccin, som har revolutionerat leverandet av mRNA Lipid nanoparticles (LNPs) are vesicular structures composed of phospholipids commonly used in vaccine formulations due to their ability to protect and encapsulate mRNA for efficient delivery to target cells. This delivery system was pivotal for the rapid development of COVID-19 mRNA vaccines. Efficient mRNA delivery depends on the particle size and stability of LNPs, making these key parameters t

BACKGROUND: Weight-adjusted-waist index (WWI) is an anthropometric index reflecting fat mass and muscle mass, both of which are important factors influencing insulin resistance and inflammation.OBJECTIVES: We aimed to examine the associations of WWI with all-cause, cardiovascular, and noncardiovascular mortality among individuals with type 2 diabetes (T2D) and further investigate whether insulin r

Cerebrospinal fluid (CSF) α-synuclein (α-syn) seed amplification assays (SAAs) can detect Lewy body pathology (LBP) with high accuracy but are invasive and costly. To address these challenges, this study evaluated a two-step workflow combining prescreening via smell-function testing with confirmatory CSF α-syn SAA testing only in individuals with reduced smell, for predicting postmortem LBP status

The influence of individual psychological and cognitive characteristics on preferences for value versus growth stocks (VSvGS) is not well understood. This study examines the influence of personality traits, financial self-efficacy (FSE), and versatile cognitive styles (VCS) on the choice between VSvGS. Specifically, it examines both the direct effects of personality traits on individual preference

Vindkraften spelar en avgörande roll i den gröna omställningen. Men vad händer när vindkraftverken nått slutet av sin livslängd? Tornen som består av enorma mängder stål återbrukas i vissa fall efter renovering men efter två–tre gånger sätter de strukturella förutsättningar stopp för återbruk och torndelarna i stål smälts oftast om till ”nytt stål”. En process som kräver mycket energi och resulterClimate change is a fact, new innovations and solutions need to be applied to mitigate the effects around the world. Greenhouse gases from burning fossil fuels are the primary cause of climate change, one of them being carbon dioxide. There are many attempts to make a turn-around regarding the use of fossil fuels and one of them is wind power. However, due to extreme loads their service life is ju

This study is concerned with examining the interrelated themes of power, resistance and exile in a Burmese context. It outlines concepts and exercise of power in Burma as well as the background of present-day leftist articulations within the anti-military movement. This study tentatively explores the context in which leftist dissidents are displaced in Thailand, and involve an investigating of the