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Super-resolution fluorescence microscopy and cryogenic soft X-ray tomography enable intracellular localization of stable nanoparticles

Cubosomes have emerged as a powerful platform for cancer treatment due to their biocompatibility and ability to encapsulate hydrophilic/lipophilic drugs, providing controlled drug release. While investigating these nanoparticles' stability and intracellular localization is essential for advancing them as clinically efficient nanomedicine, such studies are still lacking, and those available do not

The activation of metaphorical thought as a function of stimulus saliency

The automatic activation of spatial representations of affect has mainly been studied using stimuli at the extreme ends of the valence continuum, such as happy and angry facial expressions (e.g., Damjanovic & Santiago, 2016). It remains unclear whether the 'up = good' metaphor can also be triggered by stimuli with subtle valence. This issue was investigated in the current series of visual sear

Gängkriminalitet : Från gatan till sociala medier

Gängkriminaliteten har blivit en del av vardagen – tyvärr. Såväl traditionella som sociala medier svämmar över av hemska nyheter om gängens våld och verksamhet. Gangsterrap har blivit mainstream och belönas med priser.Alltför många – både pojkar och flickor – dras in i dessa miljöer, vare sig de vill det eller inte. Samtidigt sitter gängens ledare långt borta där de drar i kriminalitetenstrådar me

Unexpected shift from cyanobacterial to dinoflagellate dominance due to a summer drought

The ruling paradigm is that future climate change scenarios will lead to an increase in the frequency, intensity, and duration of cyanobacterial blooms across the globe. It was therefore unexpected when, during an unusually warm and dry summer in southern Sweden in 2018, cyanobacteria did not dominate the phytoplankton community of the temperate Lake Vombsjön known for toxic cyanobacterial blooms.

Grön utan grund? - Implementeringen av EU-direktiv 2024/825: Konsekvenser för marknadsföringslagen och företagens ansvar vid miljöpåståenden

I takt med att hållbarhet blivit en allt viktigare faktor i konsumtionsbeslut har även användningen av miljöpåståenden i marknadsföring ökat. Många företag framhåller sina produkter som "miljövänliga" eller "hållbara", men långt ifrån alla sådana påståenden har vetenskaplig grund. Fenomenet, känt som grönmålning, innebär att företag skapar en missvisande bild av sin miljöpåverkAs sustainability has become an increasingly important factor in consumer decision-making, the use of environmental claims in marketing has also risen. Many companies promote their products as "environmentally friendly" or "sustainable," yet not all such claims are based on scientific evidence. The phenomenon known as greenwashing occurs when businesses create a misleading impr

Algorithmic Management Learning

In this short paper, we reflect on ‘algorithmic management learning’ – a phenomenon that dates back to the early twentieth century but has gained fresh impetus in the dawning age of artificial intelligence. In particular, we suggest that management learning has today become a human-machine hybrid. This form of management learning is not only increasingly non-reflexive, it is also impeding the huma

Rapid subgenus identification of human adenovirus isolates by a general PCR

In most clinical situations involving adenovirus infection, subgenus (subgroup) identification of an adenovirus isolate is as informative as a finer identification by serotype. A PCR method which allows the identification of human adenovirus isolates as members of subgenera A, B:1, B:2, C, D, E, or F is described. It is based on a simple (nonnested) PCR using primers which bind to regions immediat

Who Is Responsible? Social Identity, Robot Errors and Blame Attribution

This paper argues that conventional blame practices fall short of capturing the complexity of moral experiences, neglecting power dynamics and discriminatory social practices. It is evident that robots, embodying roles linked to specific social groups, pose a risk of reinforcing stereotypes of how these groups behave or should behave, so they set a normative and descriptive standard. In addition,

The United Nations international covenant on civil and political rights : Article 27 and other provisions

The International Covenant on Civil and Political Rights (‘ICCPR’) is the only human rights treaty that has universal coverage both geographically and in respect of its personal scope, and that includes a specific provision on the rights of minorities, or to be more exact, on the rights of members of minorities. Here the Covenant differs also from the Universal Declaration of Human Rights, which d

Biosynthesis, processing and sorting of neutrophil proteins : insight into neutrophil granule development

Neutrophil granulocytes are specialized phagocytic cells that carry a collection of granules for regulated secretion, each with distinct constituents. The granules can be classified as azurophil (primary), developed first, followed in time by specific (secondary) granules gelatinase granules, and secretory vesicles. Stage- and tissue-specific transcription factors govern the successive expression

Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin

Azurocidin is a multifunctional endotoxin-binding serine protease homolog synthesized during the promyelocytic stage of neutrophil development. To characterize the biosynthesis and processing of azurocidin, cDNA encoding human preproazurocidin was stably transfected to the rat basophilic leukemia cell line RBL-1 and the murine myeloblast-like cell line 32D cl3; cell lines previously utilized to st

Processing and targeting of granule proteins in human neutrophils

Neutrophils contain an assembly of granules destined for regulated secretion, each granule type with distinct constituents formed before terminal differentiation. The earliest granules are designated azurophil (primary), followed in time by specific (secondary), and gelatinase granules as well as secretory vesicles. Transcription factors regulate the genes for the granule proteins to ensure that e

Nietzsche's Kind of Consciousness

This article critically examines two claims Mattia Riccardi ascribes to Nietzsche in his 2021 book Nietzsche’s Philosophical Psychology. The first is that Nietzsche’s main notion of consciousness should be interpreted as Rconsciousness. Rconsciousness is an awareness of a mental state or process that is achieved when that state is linguistically interpreted by another state. This article finds tha

Surface Integrity of Machined Advanced Nickel Alloys Produced by an Additive Manufacturing Route

Inconel 718 is a widely used Nickel-based alloy in the aerospace sector. However, its exceptional mechanical properties make it a very difficult material for machining operations. Additive manufacturing presents itself as a promising alternative, as it would reduce the need for post-printing material removal by machining. However, not enough research has been done about the behaviour of this mater

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Die Charakterisierung der im Schweineserum vorhandenen Inhibitorfraktionen fur Trypsin, Chymotrypsin und Elastase wurde durch Gelfiltration über Ultrogel AcA44 und Aga-rosegelelektrophorese mit anschließender Demonstration der Hemmaktivität der getrennten Fraktionen durchgeführt. Die Inhibitorfraktionen aus der Gelfiltration wurden weiterhin mittels Antikörper identifiziert, die gegen die Protease